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Clomiphene

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Identification
Molecular formula
C26H28ClNO
CAS number
911-45-5
IUPAC name
2-[[4-[2-(4-chlorophenyl)tetralin-1-yl]phenoxy]methyl]oxirane
State
State

Clomiphene is generally found in a solid state at room temperature.

Melting point (Celsius)
116.00
Melting point (Kelvin)
389.15
Boiling point (Celsius)
494.20
Boiling point (Kelvin)
767.40
General information
Molecular weight
405.97g/mol
Molar mass
405.9660g/mol
Density
1.0160g/cm3
Appearence

Clomiphene is typically a white to pale yellow crystalline powder.

Comment on solubility

Solubility of 2-[[4-[2-(4-chlorophenyl)tetralin-1-yl]phenoxy]methyl]oxirane

The solubility of the compound 2-[[4-[2-(4-chlorophenyl)tetralin-1-yl]phenoxy]methyl]oxirane can be influenced by various factors, resulting in some intriguing considerations:

  • Polar and Nonpolar Characteristics: Given its complex structure, the compound possesses both polar and nonpolar functional groups. This duality can lead to solubility in both polar solvents (like water) and nonpolar solvents (such as hexane), albeit to varying degrees.
  • Hydrophobic Interactions: The presence of the 4-chlorophenyl and the tetralin moiety adds significant hydrophobic character to the molecule, which may reduce solubility in aqueous environments.
  • Temperature Dependence: Like many organic compounds, the solubility of this compound may increase with temperature, altering the intermolecular interactions and allowing for better solubilization.
  • Potential for Formulations: Due to its interesting solubility profile, this compound could be suitable for various applications, particularly in pharmaceutical formulations where solubility is crucial for bioavailability.

Overall, the solubility of 2-[[4-[2-(4-chlorophenyl)tetralin-1-yl]phenoxy]methyl]oxirane is not straightforward, and understanding its behavior in different solvents is essential for practical applications. As always, consulting experimental data is vital to gain an accurate perspective on its solubility characteristics.

Interesting facts

Interesting Facts about 2-[[4-[2-(4-chlorophenyl)tetralin-1-yl]phenoxy]methyl]oxirane

This fascinating compound, known for its complex structure, combines elements of organic chemistry and medicinal applications. Below are some interesting aspects that highlight its significance:

  • Structural Intricacy: The molecule features multiple functional groups and rings, showcasing a remarkable level of structural complexity. This intricacy is crucial as it often dictates the compound's reactivity and interactions with biological systems.
  • Potential Biological Activity: Compounds like this often mimic the structure of natural molecules and can exhibit significant biological properties, including anti-inflammatory or analgesic effects. Researchers are keenly interested in assessing such compounds for their potential therapeutic applications.
  • Synthetic Route: The synthesis of this compound often involves multiple steps, emphasizing the creativity and problem-solving skills of chemists. Understanding the synthetic route is essential for improving yields and purities in research and pharmacological contexts.
  • Oxirane Ring: The presence of an oxirane (epoxide) ring is noteworthy; this three-membered ring is highly reactive and serves as a key functional group in organic synthesis. It can participate in nucleophilic ring-opening reactions, leading to the formation of various derivatives.
  • Application in Drug Design: The design of compounds like this is pivotal in pharmacology. Modifications of the existing structure can lead to new drugs with enhanced efficacy or reduced side effects, demonstrating the ongoing importance of such molecules in medicinal chemistry.

In summary, 2-[[4-[2-(4-chlorophenyl)tetralin-1-yl]phenoxy]methyl]oxirane embodies the intersection of structure, reactivity, and biological significance. Its examination offers insights into both theoretical concepts and practical applications in chemistry and medicine.

Synonyms
4U7Y1WZP9X
Naphthalene, 1,2,3,4-tetrahydro-2-(p-chlorophenyl)-1-(p-(2,3-epoxypropoxy)phenyl)-
13073-72-8
2-(p-Chlorophenyl)-1-(p-(2,3-epoxypropoxy)phenyl)-1,2,3,4-tetrahydro naphthalene
BRN 1328056
UNII-4U7Y1WZP9X
2-(p-Chlorophenyl)-1-(p-(2,3-epoxypropoxy)phenyl)-1,2,3,4-tetrahydronaphthalene
DTXSID00926877
Q27260514
2-({4-[2-(4-chlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]phenoxy}methyl)oxirane
NAPHTHALENE, 2-(P-CHLOROPHENYL)-1-(P-(2,3-EPOXYPROPOXY)PHENYL)-1,2,3,4-TETRAHYDRO-
OXIRANE, 2-((4-(2-(4-CHLOROPHENYL)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL)PHENOXY)METHYL)-