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Raltitrexed

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Identification
Molecular formula
C21H22N4O6
CAS number
112887-68-0
IUPAC name
2-[[4-[(2-amino-4-oxo-1H-quinazolin-6-yl)methyl-prop-2-ynyl-amino]benzoyl]amino]pentanedioic acid
State
State

At room temperature, Raltitrexed is a solid compound.

Melting point (Celsius)
185.00
Melting point (Kelvin)
458.15
Boiling point (Celsius)
355.80
Boiling point (Kelvin)
628.95
General information
Molecular weight
458.43g/mol
Molar mass
458.4320g/mol
Density
1.5300g/cm3
Appearence

Raltitrexed is typically found as a white to slightly yellow crystalline powder. It is often presented in its hydrated form.

Comment on solubility

Solubility of 2-[[4-[(2-amino-4-oxo-1H-quinazolin-6-yl)methyl-prop-2-ynyl-amino]benzoyl]amino]pentanedioic acid (C21H22N4O6)

The solubility of the compound 2-[[4-[(2-amino-4-oxo-1H-quinazolin-6-yl)methyl-prop-2-ynyl-amino]benzoyl]amino]pentanedioic acid is influenced by various factors including its structure and functional groups. This compound features both hydrophilic and hydrophobic regions, which can impact how well it dissolves in different solvents.

Here are some key points regarding its solubility:

  • Water Solubility: It is likely to show moderate solubility in water due to the presence of multiple polar functional groups, such as amino and carboxylic acid groups.
  • Organic Solvents: The compound may exhibit higher solubility in organic solvents such as ethanol or dimethyl sulfoxide (DMSO), thanks to its hydrophobic aromatic systems.
  • Temperature Influence: As with many compounds, the solubility may increase with temperature, allowing for greater molecular motion and interaction with solvent molecules.
  • pH Dependency: The ionization of the carboxylic acid groups may also affect solubility. In acidic or basic environments, the ionized form may be more soluble due to increased interaction with polar solvents.

Overall, understanding the solubility characteristics of this compound is essential for applications in pharmaceuticals and material sciences. As Dr. Antoine Lavoisier famously stated, “Nothing is lost, nothing is created, everything is transformed,” emphasizing the importance of solubility in the context of chemical transformations and reactions.

Interesting facts

Interesting Facts about 2-[[4-[(2-amino-4-oxo-1H-quinazolin-6-yl)methyl-prop-2-ynyl-amino]benzoyl]amino]pentanedioic acid

This compound is a fascinating example of a multi-functional molecule, integrating a quinazoline moiety known for its biological activity. Quinazolines are often recognized in medicinal chemistry for their diverse therapeutic properties, which include anti-cancer and anti-inflammatory effects.

Here are some notable aspects of this compound:

  • Complex Structure: The intricate design features a combination of various functional groups, enhancing its potential biological interactions.
  • Biological Relevance: The presence of amino and carbonyl functional groups typically contributes to biological reactivity, making such compounds ideal candidates for drug development.
  • Mechanism of Action: Compounds like this one can play a crucial role in enzyme inhibition or receptor binding, where structural modifications alter their affinity and efficacy.
  • Synthesis & Applications: The synthesis of this compound might involve advanced organic chemistry techniques such as coupling reactions or multi-step syntheses, illustrating the complexity of producing biologically active molecules.
  • Research Potential: As scientists explore the properties of similar compounds, research continues into their applications in treating diseases, particularly in oncology and pharmacology.

As stated by many researchers in the field, "The chemistry of complex molecules often holds the key to understanding the biological systems they interact with." This quote perfectly encapsulates the essence of studying compounds like 2-[[4-[(2-amino-4-oxo-1H-quinazolin-6-yl)methyl-prop-2-ynyl-amino]benzoyl]amino]pentanedioic acid, as they bridge the gap between chemistry and medicine.

In summary, this compound showcases not just the potential for therapeutic use but also the intricate dance of chemical components that formulates its unique identity in the vast world of medicinal chemistry.