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Nedocromil

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Identification
Molecular formula
C19H16N2O7S
CAS number
69049-73-6
IUPAC name
2-[[4-(2-carboxypyrrolidin-1-yl)sulfonylbenzoyl]amino]pentanedioic acid
State
State

Nedocromil is typically found as a solid at room temperature, most often as a crystalline powder.

Melting point (Celsius)
292.00
Melting point (Kelvin)
565.15
Boiling point (Celsius)
695.30
Boiling point (Kelvin)
968.45
General information
Molecular weight
415.40g/mol
Molar mass
415.3790g/mol
Density
1.7900g/cm3
Appearence

Nedocromil is typically presented as a pale yellow powder. It is commonly found in its sodium salt form when used for medicinal purposes, particularly in inhalers for asthma treatment.

Comment on solubility

Solubility of 2-[[4-(2-carboxypyrrolidin-1-yl)sulfonylbenzoyl]amino]pentanedioic acid

The solubility of 2-[[4-(2-carboxypyrrolidin-1-yl)sulfonylbenzoyl]amino]pentanedioic acid (C19H16N2O7S) is an interesting subject due to its complex structure. Several factors impact the solubility of this compound:

  • Polarity: The presence of the carboxyl groups in the structure contributes to its polar nature, thereby enhancing its solubility in polar solvents like water.
  • Functional Groups: The sulfonyl and amino functional groups play a significant role as they can interact favorably with solvent molecules, leading to increased solubility.
  • Hydrogen Bonding: The ability to form hydrogen bonds with water molecules can significantly affect the dissolution process, making it more soluble.
  • pH Dependency: The solubility may vary with changes in pH due to protonation or deprotonation of the carboxylic acid groups.

In conclusion, while the solubility of this compound in water and organic solvents may reach varying degrees, it is generally favorable due to the combination of polar functional groups and the capacity for hydrogen bonding. As a result, it illustrates the intricate balance between structural composition and solubility behavior.

Interesting facts

Interesting Facts about 2-[[4-(2-carboxypyrrolidin-1-yl)sulfonylbenzoyl]amino]pentanedioic acid

This compound, known for its complex structure and multifunctional properties, is a fascinating subject of study in the field of medicinal chemistry. Here are some intriguing points to consider:

  • Pharmaceutical Potential: The unique combination of a pyrrolidine ring and sulfonyl moiety suggests that this compound may possess bioactive properties that could be harnessed in drug development.
  • Bioconjugation: The presence of multiple functional groups, such as the carboxyl and amine groups, indicates its potential as a bioconjugation tool. This could allow for the targeted delivery of therapeutic agents.
  • Structure-Activity Relationship (SAR): Understanding the structure of this compound can lead to insights regarding its biological activity and effectiveness, making it a valuable candidate for SAR studies.
  • Research Applications: The compound may have implications in areas such as enzyme inhibition or receptor antagonism, which are critical areas in the development of new pharmacological therapies.
  • Interdisciplinary Interest: This compound embodies a blend of chemistry, biology, and pharmacology, making it attractive not just to chemists, but also to biologists and pharmacologists seeking to explore its therapeutic possibilities.

As research continues to evolve, compounds like 2-[[4-(2-carboxypyrrolidin-1-yl)sulfonylbenzoyl]amino]pentanedioic acid serve as a reminder of the intricate relationship between chemical structure and biological function.

In the words of a great chemist, "Chemistry is the study of transformation, and each compound tells a different story about the possibilities of matter."