Skip to main content

Tamoxifen

ADVERTISEMENT
Identification
Molecular formula
C26H29ClNO
CAS number
10540-29-1
IUPAC name
2-[4-(2-chloro-1,2-diphenyl-vinyl)phenoxy]-N,N-diethyl-ethanamine
State
State

At room temperature, tamoxifen is in a solid state, specifically appearing as a crystalline powder.

Melting point (Celsius)
140.00
Melting point (Kelvin)
413.15
Boiling point (Celsius)
537.30
Boiling point (Kelvin)
810.45
General information
Molecular weight
371.52g/mol
Molar mass
371.5220g/mol
Density
1.0077g/cm3
Appearence

Tamoxifen typically appears as a white or off-white crystalline powder. It may have a faint characteristic odor. This compound is often presented in tablet or solution form, especially when used in pharmaceutical contexts.

Comment on solubility

Solubility of 2-[4-(2-chloro-1,2-diphenyl-vinyl)phenoxy]-N,N-diethyl-ethanamine (C26H29ClNO)

The solubility of the compound 2-[4-(2-chloro-1,2-diphenyl-vinyl)phenoxy]-N,N-diethyl-ethanamine can be characterized by several important factors:

  • Polarity: The presence of the amine group and chlorine atom implies a degree of polarity, which can affect solubility in polar solvents like water.
  • Hydrophilicity vs. Hydrophobicity: This compound is expected to exhibit hydrophobic characteristics due to its large aromatic structure, which may lead to limited solubility in aqueous environments.
  • Solvent Type: It is likely to be more soluble in organic solvents such as ethanol, dichloromethane, or ethyl acetate due to non-polar interactions.
  • Temperature Dependency: Solubility may increase with temperature, as the kinetic energy can help disrupt intermolecular forces.

In summary, while the specific solubility data for this compound may not be readily available, its structure suggests that it will have limited solubility in polar solvents and may be more soluble in non-polar organic solvents. Understanding the solubility profile is crucial for its potential applications in various fields, particularly in pharmaceuticals and material science.

Interesting facts

Interesting Facts about 2-[4-(2-chloro-1,2-diphenyl-vinyl)phenoxy]-N,N-diethyl-ethanamine

This intriguing compound belongs to a class of chemical substances that exhibit a variety of potential applications, particularly in the fields of medicinal chemistry and materials science.

Key Features

  • Versatile Applications: The unique structure of this compound makes it a candidate for use in pharmaceuticals, particularly as a starting point for developing new drugs.
  • Structural Complexity: The presence of both a chloro substituent and a biphenyl segment contributes to its intricate molecular architecture, which can impact its reactivity and stability.
  • Phenoxy Group Significance: The phenoxy functional group is known to enhance biological activity and solubility, making it a common motif in drug design.
  • Potential Biological Activity: Compounds of this nature are often explored for their interactions with cellular mechanisms, particularly in the context of cancer research and other therapeutic areas.

Chemical Significance

Understanding such compounds can lead to breakthroughs in drug synthesis and materials development. As noted by chemists, “The relationship between structure and activity is crucial in the design process for effective compounds.” This emphasizes the importance of examining every atom and bond in such complex structures.

In conclusion, 2-[4-(2-chloro-1,2-diphenyl-vinyl)phenoxy]-N,N-diethyl-ethanamine is not just a simple compound; it is a fascinating example of how chemistry intertwines with potential real-world applications. Its study opens doors to innovations in therapeutic agents and materials!

Synonyms
clomiphene
Clomifene
Clomifenum
Clomiphene B
Clomifeno
911-45-5
Mer 41
Cisclomiphene
Clomiphene free base
Clomifenum [INN-Latin]
Clomifeno [INN-Spanish]
UNII-1HRS458QU2
Chlomaphene
Chloramifene
Androxal
Clomifen
2-(p-(2-Chloro-1,2-diphenylvinyl)phenoxy)triethylamine
1HRS458QU2
CHEBI:3752
911-45-5 (free base)
DTXSID1022843
HSDB 3039
2-[4-(2-chloro-1,2-diphenylethenyl)phenoxy]-N,N-diethylethanamine
EINECS 213-008-6
NSC 35770
2-(p-(beta-chloro-alpha-phenylstyryl)phenoxy)triethylamine
2-(p-(beta-Chloro-alpha-phenylstyryl)phenoxy)-triethylamine
Clomifenum (INN-Latin)
1-(p-(beta-Diethylaminoethoxy)-phenyl)-1,2-diphenylchloroethylene
Clomifeno (INN-Spanish)
Ethanamine, 2-[4-(2-chloro-1,2-diphenylethenyl)phenoxy]-N,N-diethyl-
2-(4-(2-Chloro-1,2-diphenylethenyl)phenoxy)-N,N-diethylethanamine
Ethanamine, 2-(4-(2-chloro-1,2-diphenylethenyl)phenoxy)-N,N-diethyl-
Clomiphene; Clomiphene B
Clomifene [INN:BAN]
DTXCID202843
Triethylamine, 2-(p-(2-chloro-1,2-diphenylvinyl)phenoxy)-
1-[p-(beta-diethylaminoethoxy)phenyl]-1,2-diphenylchloroethylene
1-(P-(BETA-DIETHYLAMINOETHOXY)PHENYL)-1,2-DIPHENYLCHLOROETHYLENE
(E)-Clomiphene;trans-Clomiphene;Enclomifene
Spectrum_000101
Prestwick0_000397
Prestwick1_000397
Spectrum2_001139
Spectrum3_000357
Spectrum4_000294
C26H28ClNO
SCHEMBL34893
KBioGR_000848
KBioSS_000541
DivK1c_000462
SPBio_001037
SPBio_002534
{2-[4-(2-chloro-1,2-diphenylethenyl)phenoxy]ethyl}diethylamine
GTPL4159
CHEMBL2355051
KBio1_000462
KBio2_000541
KBio2_003109
KBio2_005677
KBio3_001273
G03GB02
GKIRPKYJQBWNGO-UHFFFAOYSA-N
NINDS_000462
HMS3373N06
QAA69057
2-[4-(2-chloro-1,2-diphenyl-vinyl)phenoxy]-N,N-diethyl-ethanamine
DB00882
SB17213
NCGC00164385-04
NCGC00249615-01
Q418730
Q28208734
1-[4-(2-diethylaminoethoxy)phenyl]-1,2-diphenyl-2-chloroethylene
2-(4-(2-CHLORO-1,2-DIPHENYLETHENYL)-PHENOXY)-N,N-DIETHYLETHANAMINE
213-008-6