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TFMPP (Trifluoromethylphenylpiperazine)

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Identification
Molecular formula
C21H25ClN2O4
CAS number
15532-75-9
IUPAC name
2-[4-(2-chlorophenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone
State
State

This compound is a solid at room temperature. It remains stable under normal conditions and is typically stored in a cool, dry place to maintain its integrity.

Melting point (Celsius)
190.00
Melting point (Kelvin)
463.20
Boiling point (Celsius)
465.50
Boiling point (Kelvin)
738.60
General information
Molecular weight
388.88g/mol
Molar mass
388.8780g/mol
Density
1.2300g/cm3
Appearence

The compound typically appears as a white to off-white solid crystalline powder. This characteristic appearance can vary slightly based on purity and methods of synthesis but remains consistent under standard storage conditions.

Comment on solubility

Solubility of 2-[4-(2-chlorophenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone

The solubility of 2-[4-(2-chlorophenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone can be quite interesting and complex due to its molecular structure.

Key Factors Influencing Solubility:

  • Polar and Non-Polar Characteristics: Given its intricate combination of piperazine and aromatic rings, the molecule exhibits both polar and non-polar characteristics that influence its solubility in various solvents.
  • Hydrophobic Interactions: The presence of methoxy groups adds hydrophobic properties, suggesting limited solubility in polar solvents like water.
  • Solvent Compatibility: It is likely to show higher solubility in organic solvents such as ethanol or dimethyl sulfoxide (DMSO) due to its non-polar regions.

As a rule of thumb, the phrase "like dissolves like" can be useful to remember when considering solubility. This means:

  • If a solvent is polar, it will typically dissolve polar compounds well.
  • If a solvent is non-polar, it will generally dissolve non-polar compounds better.

Therefore, while 2-[4-(2-chlorophenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone is expected to have limited solubility in aqueous solutions, it may show significant solubility in organic solvents. Experimentation is key to defining its solubility profile more accurately in various conditions.

Interesting facts

Exploring 2-[4-(2-chlorophenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone

This fascinating compound is known for its complex structure and potential therapeutic applications. Below are some intriguing facts that highlight its significance in the field of chemistry:

  • Pharmacological Interest: The compound's unique piperazine ring gives it properties that are investigated for various pharmaceutical applications, particularly in the realm of neuropharmacology.
  • Structural Components: The presence of the trimethoxyphenyl group enhances the lipophilicity of the molecule, which can influence its ability to cross the blood-brain barrier.
  • Biological Activity: Some studies suggest this compound exhibits activity that could potentially modulate serotonin receptors, making it of interest for developing treatments for mood disorders.
  • Chlorophenyl Influence: The 2-chlorophenyl group is known to affect the biological efficacy of similar compounds, often enhancing their potency and selectivity.
  • Synthetic Chemistry: The synthesis of this compound involves intriguing reaction pathways, showcasing the interplay of organic synthesis and medicinal chemistry.

In conclusion, 2-[4-(2-chlorophenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone stands as a testament to the ongoing research in drug development, offering exciting prospects for both scientists and pharmacologists. Its multifunctional characteristics not only invite further study but also illustrate the complexity of designing compounds that can effectively interact with biological systems. As a quote from the field rightly puts it, "The beauty of chemistry lies in the connections the structures can create."

Synonyms
BRN 1605299
17755-62-3
ACETOPHENONE, 2-(4-(o-CHLOROPHENYL)PIPERAZINYL)-3',4',5'-TRIMETHOXY-
2-(4-(o-Chlorophenyl)piperazinyl)-3',4',5'-trimethoxyacetophenone
1-(o-Chlorophenyl)-4-(3,4,5-trimethoxybenzoylmethyl)piperazine
DTXSID80170331
Piperazine, 1-(o-chlorophenyl)-4-(3,4,5-trimethoxybenzoylmethyl)-
DTXCID5092822
5-23-02-00260 (Beilstein Handbook Reference)