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Flurbiprofen

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Identification
Molecular formula
C15H13FO2
CAS number
5104-49-4
IUPAC name
2-[4-(2-fluorophenyl)phenyl]acetic acid
State
State

At room temperature, Flurbiprofen is typically found in a solid state as a crystalline powder.

Melting point (Celsius)
111.00
Melting point (Kelvin)
384.15
Boiling point (Celsius)
433.20
Boiling point (Kelvin)
706.35
General information
Molecular weight
244.27g/mol
Molar mass
244.2670g/mol
Density
1.2500g/cm3
Appearence

Flurbiprofen is a white to off-white crystalline powder. It is sparingly soluble in water and freely soluble in ethanol.

Comment on solubility

Solubility of 2-[4-(2-fluorophenyl)phenyl]acetic acid

2-[4-(2-fluorophenyl)phenyl]acetic acid is a fascinating compound with unique solubility characteristics. Understanding its solubility is critical for various applications, particularly in pharmaceutical and chemical industries. Here are some key points regarding its solubility:

  • Solvent Dependence: This compound is typically soluble in organic solvents such as ethanol and dimethyl sulfoxide (DMSO), owing to its aromatic structures that facilitate interactions with nonpolar solvents.
  • Aqueous Solubility: The solubility in water may be limited, often classified as sparingly soluble due to its hydrophobic phenyl groups, which hinder interaction with polar water molecules.
  • Temperature Effects: Like many organic compounds, solubility can improve with an increase in temperature. This is a common behavior observed in many acids and organic compounds.
  • pH Sensitivity: The solubility of carboxylic acids generally increases with higher pH levels, leading to the formation of the anionic form, which is more soluble in aqueous solutions.

In conclusion, understanding the solubility of 2-[4-(2-fluorophenyl)phenyl]acetic acid is essential for its effective use in various applications. It showcases how solubility can be influenced by factors like the solvent nature, temperature, and pH, highlighting the intricate balance of these interactions.

Interesting facts

Interesting Facts about 2-[4-(2-Fluorophenyl)phenyl]acetic Acid

2-[4-(2-Fluorophenyl)phenyl]acetic acid is a fascinating compound that has drawn attention in the fields of medicinal chemistry and organic synthesis. Here are some intriguing points about this compound:

  • Structural Complexity: The compound's structure features two aromatic rings, which contribute to its unique chemical behavior and interactions. The substitution of a fluorine atom plays a vital role in altering both its physical and chemical properties.
  • Pharmacological Potential: Due to its structural resemblance to non-steroidal anti-inflammatory drugs (NSAIDs), research has been conducted to explore its potential therapeutic applications, particularly in pain management and inflammation.
  • Fluorine Influence: The presence of a fluorine atom often enhances the biological activity of compounds. This characteristic is attributed to fluorine's electronegativity, potentially influencing binding affinity to biological targets.
  • Synthetic Routes: The synthesis of 2-[4-(2-fluorophenyl)phenyl]acetic acid generally involves advanced organic chemistry techniques, showcasing the creativity and skills of chemists in constructing complex molecules from simpler precursors.
  • Applications in Research: This compound is frequently used in scientific research as a model to study molecular interactions, drug efficacy, and the development of new therapeutic agents.

As an individual interested in chemistry, one might say: "The exploration of compounds like 2-[4-(2-fluorophenyl)phenyl]acetic acid not only enhances our understanding of chemical structures but also opens doors to groundbreaking advancements in pharmaceuticals." The ongoing study of this compound reflects the dynamic and ever-evolving nature of chemical science.

Synonyms
5001-99-0
4-BIPHENYLACETIC ACID, 2'-FLUORO-
AFV 2
2'-Fluoro-4-biphenylacetic acid
BRN 1574000
2-(2'-Fluor-4-biphenylyl)-essigsaeure [German]
2-(2'-Fluor-4-biphenylyl)-essigsaeure
DTXSID90198187
DTXCID20120678
2-[4-(2-fluorophenyl)phenyl]acetic acid
2-(2-Fluor-4-biphenylyl)-essigsaeure [German]
SCHEMBL1177292
HSOKOZJRZALFLQ-UHFFFAOYSA-N
AKOS004117068
(2'-fluoro-biphenyl-4-yl)-acetic acid
(2'-Fluoro[1,1'-biphenyl]4-yl)acetic Acid
(2'-fluoro[1,1'-biphenyl]-4-yl)acetic acid
2-(2'-Fluoro-[1,1'-biphenyl]-4-yl)acetic acid
Z2574936194