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Flurbiprofen

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Identification
Molecular formula
C15H13FO2
CAS number
5104-49-4
IUPAC name
2-[4-(2-fluorophenyl)phenyl]propanoic acid
State
State

At room temperature, Flurbiprofen is a solid. It is stable under normal conditions and typically used in the pharmaceutical industry in its solid form.

Melting point (Celsius)
111.00
Melting point (Kelvin)
384.15
Boiling point (Celsius)
291.00
Boiling point (Kelvin)
564.15
General information
Molecular weight
244.26g/mol
Molar mass
244.2640g/mol
Density
1.2990g/cm3
Appearence

Flurbiprofen appears as a white to off-white crystalline powder. It is often odorless and has a characteristic crystalline structure typically used for analytical and formulation purposes.

Comment on solubility

Solubility of 2-[4-(2-fluorophenyl)phenyl]propanoic acid

2-[4-(2-fluorophenyl)phenyl]propanoic acid, known for its unique structure, exhibits interesting solubility characteristics. When considering the solubility of this compound, several factors come into play:

  • Solvent Type: This compound is likely to dissolve more readily in organic solvents such as ethanol or acetone due to its aromatic and aliphatic components.
  • Polarity: The presence of the carboxylic acid group contributes to a polar character, allowing for some degree of solubility in polar solvents.
  • Temperature Effects: Generally, increasing temperature can enhance solubility, which is a common phenomenon for many organic compounds.
  • pH Influence: The solubility can also be affected by the pH of the solution, particularly because the carboxylic acid can ionize in basic conditions, leading to increased solubility.

In summary, while 2-[4-(2-fluorophenyl)phenyl]propanoic acid shows some variability in solubility depending on the conditions, it demonstrates a good potential for solubility in both polar and non-polar environments. As stated, "Solubility is a complex phenomenon that illustrates the interaction between structure and solvent." Understanding these factors is critical for its application in various fields.

Interesting facts

Interesting Facts About 2-[4-(2-Fluorophenyl)phenyl]propanoic Acid

2-[4-(2-Fluorophenyl)phenyl]propanoic acid, known in the scientific community for its unique structure and properties, is a fascinating chemical compound that often grabs the attention of chemists and researchers. Here are some intriguing points about this compound:

  • Biodiversity in Bioactivity: This compound exhibits various biological activities, making it of interest in medicinal chemistry. Its fluorinated aromatic ring enhances lipophilicity, which can improve its pharmacological properties.
  • Role in Research: Frequently studied in the context of anti-inflammatory and analgesic effects, the compound can offer insights into the development of non-steroidal anti-inflammatory drugs (NSAIDs).
  • Synthetic Pathways: The synthesis of this compound often involves complex organic reactions, showcasing the beauty and intricacy of organic chemistry. Techniques such as Friedel-Crafts reactions can be employed in its formation.
  • Environmental Impact: As fluorinated compounds can persist in the environment, studying their degradation pathways is crucial for understanding their ecological footprint.
  • Structure-Activity Relationship (SAR): Investigating how the specific substitutions on the aromatic rings affect bioactivity is a core aspect of this compound’s research.

As one delves deeper into the realm of 2-[4-(2-fluorophenyl)phenyl]propanoic acid, it becomes clear that this compound serves as a key example of how chemical modifications can lead to diverse functionality. Its exploration not only provides valuable insights into organic synthesis but also paves the way for advancements in medicinal applications.

Synonyms
AFV 5
5005-84-5
2'-Fluoro-alpha-methyl-4-biphenylacetic acid
BRN 2054452
2-(2'-Fluor-4-biphenyl)-propionsaeure [German]
2-(2'-Fluor-4-biphenyl)-propionsaeure
4-BIPHENYLACETIC ACID, 2'-FLUORO-alpha-METHYL-
2-(2'-fluoro[1,1'-biphenyl]-4-yl)propanoic acid
SCHEMBL1072964
DTXSID10964503
MSUHIIYPJIGYBH-UHFFFAOYSA-N
2-(2'-fluoro-biphenyl-4-yl)-propionic acid
2-(2'-Fluoro-[1,1'-biphenyl]-4-yl)propanoic acid