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Prochlorperazine

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Identification
Molecular formula
C20H24N3O1S1
CAS number
58-38-8
IUPAC name
2-[4-(2-hydroxyethyl)piperazin-1-yl]-1-phenothiazin-10-yl-ethanone
State
State

At room temperature, Prochlorperazine is typically in a solid state, existing as a crystalline powder. It is marginally soluble in water, indicating it mainly needs to be delivered in formulations that aid in its solubility for clinical use.

Melting point (Celsius)
206.00
Melting point (Kelvin)
479.15
Boiling point (Celsius)
375.20
Boiling point (Kelvin)
648.40
General information
Molecular weight
373.50g/mol
Molar mass
373.9220g/mol
Density
1.2010g/cm3
Appearence

Prochlorperazine is typically found as a white to pale yellow crystalline powder. It may appear as odorless or with a slight odor, and it is often used in its salt form, the most common being the maleate or edisylate salt, which appear as fine crystals or powders.

Comment on solubility

Solubility of 2-[4-(2-hydroxyethyl)piperazin-1-yl]-1-phenothiazin-10-yl-ethanone

The solubility of the compound 2-[4-(2-hydroxyethyl)piperazin-1-yl]-1-phenothiazin-10-yl-ethanone is an important factor to consider when assessing its potential applications. This compound exhibits a unique structure that contributes to its solubility characteristics. Here are some key points about its solubility:

  • Polarity: The presence of the hydroxyl group (-OH) in the structure increases polarity, which typically enhances solubility in polar solvents such as water.
  • Solvent Interaction: This compound is expected to show good solubility in a variety of aqueous and organic solvents due to the balance of hydrophilic and hydrophobic regions in its molecular structure.
  • pH Dependence: As a piperazine-like compound, its solubility may vary with pH levels due to potential protonation of the amine groups, influencing its interaction with solvents.
  • Temperature Effects: Generally, solubility can increase with temperature; thus, raising the temperature can enhance the compound's dissolution in various solvents.

In summary, this compound likely possesses a favorable solubility profile, particularly in polar solvents, enabling it to be utilized effectively in various chemical and pharmaceutical processes. Understanding these solubility traits is crucial for its application in formulations.

Interesting facts

Interesting Facts about 2-[4-(2-hydroxyethyl)piperazin-1-yl]-1-phenothiazin-10-yl-ethanone

This compound is a fascinating example of a phenothiazine derivative, a class of compounds that has gained attention in medicinal chemistry due to its diverse biological activities. Here are some intriguing insights:

  • Pharmacological Significance: Phenothiazines, including this compound, are known for their antipsychotic properties. They were originally developed as tranquilizers and have paved the way for the treatment of various mental health disorders.
  • Structural Complexity: The molecular structure of this compound features a piperazine ring and an ethanolamine side chain, contributing to its pharmacological profile and influence on the central nervous system.
  • Versatile Applications: Beyond their role in psychiatric medications, phenothiazines are also utilized in veterinary medicine and as antiemetics, showcasing the broad utility of this class of compounds.
  • Research Insights: Ongoing research into derivatives like this one aims to enhance efficacy and reduce side effects, making them more suitable for long-term treatment regimens.

Through collaborations in medicinal chemistry and biology, scientists continue to explore how modifications to the chemical structure of such compounds can lead to improved therapeutic options. As Professor Smith aptly stated, "The beauty of medicinal chemistry lies in our ability to tinker with molecular structures to uncover new realms of healing."

In summary, 2-[4-(2-hydroxyethyl)piperazin-1-yl]-1-phenothiazin-10-yl-ethanone epitomizes the intricate dance between structure and function in the realm of medicinal compounds.