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Prochlorperazine dihydrochloride

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Identification
Molecular formula
C20H24Cl3N3OS
CAS number
52-07-1
IUPAC name
2-[4-(2-hydroxyethyl)piperazin-1-yl]-1-phenothiazin-10-yl-ethanone;dihydrochloride
State
State

At room temperature, Prochlorperazine dihydrochloride is in a solid state.

Melting point (Celsius)
228.00
Melting point (Kelvin)
501.15
Boiling point (Celsius)
310.00
Boiling point (Kelvin)
583.15
General information
Molecular weight
460.85g/mol
Molar mass
460.3790g/mol
Density
1.3600g/cm3
Appearence

Prochlorperazine dihydrochloride typically appears as a white to faintly yellowish crystalline powder.

Comment on solubility

Solubility of 2-[4-(2-hydroxyethyl)piperazin-1-yl]-1-phenothiazin-10-yl-ethanone; dihydrochloride

The compound 2-[4-(2-hydroxyethyl)piperazin-1-yl]-1-phenothiazin-10-yl-ethanone; dihydrochloride is characterized by its unique structure, which often influences its solubility profile. Understanding the solubility characteristics is crucial for applications in pharmaceuticals and material sciences.

In general, the solubility of this compound can be affected by several factors:

  • Polarity: The presence of multiple functional groups, such as hydroxyl (-OH) and piperazine, tends to increase polarity, enhancing solubility in polar solvents like water.
  • Hydrochloride Salt Form: The formation of a dihydrochloride salt typically increases the solubility of the compound in aqueous solutions, as ionic interactions facilitate dissolution in solvent.
  • Temperature: Increasing temperature often increases solubility; this is particularly relevant for compounds that may display variable solubility characteristics at different temperatures.

Based on these factors, one might observe that 2-[4-(2-hydroxyethyl)piperazin-1-yl]-1-phenothiazin-10-yl-ethanone; dihydrochloride likely exhibits good water solubility, particularly due to its ionic nature and polar substituents. This makes it suitable for formulation in various aqueous environments, which is pivotal for its bioavailability in pharmaceutical applications.

To summarize, when considering the solubility of this compound, it is essential to take into account:

  1. The ionic form enhances solubility
  2. The impact of temperature
  3. The role of functional group polarity

Such detailed considerations ensure informed decisions for its use in practical applications.

Interesting facts

Interesting Facts about 2-[4-(2-hydroxyethyl)piperazin-1-yl]-1-phenothiazin-10-yl-ethanone; dihydrochloride

This compound, known for its complex structure and significant biological activity, is primarily used in the field of pharmaceuticals. Let's explore some fascinating details:

  • Pharmacological Properties: The compound exhibits notable activity as an antipsychotic agent, interacting with various neurotransmitter systems in the brain. This makes it potentially beneficial in the treatment of mental health disorders such as schizophrenia.
  • Structural Characteristics: The unique presence of the phenothiazine ring in its structure contributes to its therapeutic effects. Phenothiazines are a class of medications that have been widely researched and utilized since the mid-20th century.
  • Hydroxyethyl Group: The hydroxyethyl substituent enhances the solubility and pharmacokinetic profile of the compound, allowing for improved absorption in biological systems.
  • Mode of Action: This compound is thought to act by blocking dopamine receptors, with possible impacts on serotonin receptors as well, showcasing how nuanced interactions within the brain can lead to therapeutic outcomes.
  • Clinical Relevance: Its derivative forms have inspired numerous studies, exploring its efficacy, safety, and potential dose-dependent responses in patient populations.

Additionally, it’s worth noting that this compound plays a role in ongoing research aimed at developing better treatments with fewer side effects, reflecting the dynamic nature of medicinal chemistry. As more discoveries are made in the field, compounds like this one could pave the way for new therapeutic strategies in combating psychological disorders.

Synonyms
Ketone, (4-(2-hydroxyethyl)piperazinyl)methyl phenothiazin-10-yl, dihydrochloride
29573-89-5
DTXSID90183750
Phenothiazine, 10-(2-(4-(2-hydroxyethyl)piperazinyl)acetyl)-, dihydrochloride
RefChem:350363
DTXCID30106241