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Trazodone

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Identification
Molecular formula
C19H22N2O4
CAS number
19794-93-5
IUPAC name
2-[4-(2-methoxyphenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone
State
State

At room temperature, trazodone is typically a solid.

Melting point (Celsius)
87.00
Melting point (Kelvin)
360.15
Boiling point (Celsius)
578.20
Boiling point (Kelvin)
851.35
General information
Molecular weight
371.45g/mol
Molar mass
371.4470g/mol
Density
1.2830g/cm3
Appearence

Trazodone is typically found as a white or off-white crystalline powder.

Comment on solubility

Solubility Overview

The solubility of the compound 2-[4-(2-methoxyphenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone is an intriguing aspect to investigate due to its complex structure and the presence of multiple functional groups.

Factors Affecting Solubility

Several factors contribute to the solubility of this compound, including:

  • Polarity: The presence of methoxy groups increases the polarity, which can enhance solubility in polar solvents.
  • Hydrogen Bonding: The ability of the compound to form hydrogen bonds can also impact its solubility. Molecules with hydrogen bond donors or acceptors often display increased solubility in polar solvents.
  • Size and Steric Hindrance: The size of the molecule and spatial arrangement can influence solubility in various solvents.

Expected Solubility Characteristics

In general, one may anticipate:

  • High solubility in polar organic solvents such as methanol and ethanol due to the presence of methoxy groups.
  • Low solubility in nonpolar solvents like hexane or cyclohexane, as the compound's polar characteristics do not favor solvation in such environments.

Understanding the solubility dynamics of this compound is essential for its applications in medicinal chemistry and pharmacology, where solubility can directly influence bioavailability and therapeutic effectiveness.

Interesting facts

Interesting Facts about 2-[4-(2-Methoxyphenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone

This compound, often noted for its complex structure, showcases a fascinating example of medicinal chemistry in action. With its intricate arrangement of functional groups, it is particularly intriguing due to its implications in various fields, especially pharmacology.

Key Features:

  • Medicinal Potential: The compound is a derivative of piperazine, a chemical structure often found in pharmacologically active substances. This highlights its potential use in drug development, specifically for conditions like anxiety and depression due to its piperazine moiety.
  • Complex Aromatic System: The presence of multiple methoxy groups on the aromatic rings increases the lipophilicity of the compound, which can affect its absorption and distribution in biological systems.
  • Synthetic Versatility: The method of synthesizing this compound can involve multiple steps including functionalization and coupling reactions, demonstrating the versatility of organic synthesis in designing new compounds.
  • Research Interest: Chemists and biochemists continue to investigate the pharmacodynamics and pharmacokinetics of this type of compound, which adds to the ever-expanding library of medicinal compounds in drug discovery.

Additionally, compounds like this are often explored for their ability to interact with specific neurotransmitter systems. As one researcher aptly put it, "Understanding the nuanced behavior of compounds at the molecular level is essential for breakthroughs in therapeutic applications."

With ongoing research, the future of 2-[4-(2-methoxyphenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone remains bright, holding promise for new therapeutic strategies.

Synonyms
16785-20-9
2-(4-(o-Methoxyphenyl)piperazinyl)-3',4',5'-trimethoxyacetophenone
1-(o-Methoxyphenyl)-4-(3,4,5-trimethoxybenzoylmethyl)piperazine
ACETOPHENONE, 2-(4-(o-METHOXYPHENYL)PIPERAZINYL)-3',4',5'-TRIMETHOXY-
DTXSID90168406
Piperazine, 1-(o-methoxyphenyl)-4-(3,4,5-trimethoxybenzoylmethyl)-
DTXCID4090897
2-[4-(2-methoxyphenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone