Sulinamid | Solubility of Things

Identification

Molecular formula

C₁₈H₁₇NO₄S

CAS number

680-39-7

IUPAC name

2-[4-(2-naphthylsulfonylamino)phenyl]ethanehydroxamic acid

State

At room temperature, sulinamid exists in a solid state as a powder. This stability and state make it suitable for a variety of applications in research and chemical analysis where it might be required in powder form.

Melting point (Celsius)

183.00

Melting point (Kelvin)

456.00

Boiling point (Celsius)

623.00

Boiling point (Kelvin)

896.00

General information

Molecular weight

377.44g/mol

Molar mass

377.4380g/mol

Density

1.3560g/cm³

Appearence

Sulinamid is typically a solid at room temperature, appearing as a white to off-white powder. The compound may have a slight characteristic odor depending on its purity and the presence of any impurities or solvents associated with its preparation or storage.

Comment on solubility

Solubility of 2-[4-(2-naphthylsulfonylamino)phenyl]ethanehydroxamic acid

The compound 2-[4-(2-naphthylsulfonylamino)phenyl]ethanehydroxamic acid, with the chemical formula C₁₈H₁₇NO₄S, exhibits notable properties concerning its solubility. When evaluating this compound, several key factors come into play:

Polar Functional Groups: The presence of hydroxamic acid and sulfonamide functional groups often increases solubility in polar solvents such as water.
Hydrophobic Character: The naphthyl group introduces a degree of hydrophobicity, which may reduce solubility in aqueous environments.
pH Dependency: Solubility might vary significantly with changes in pH, where acidic or basic conditions can affect the ionization states of the functional groups.

In general, one might expect that:

At neutral pH, this compound could possess moderate solubility in water due to its polar character.
In organic solvents, such as ethanol or DMSO, solubility may be significantly higher due to the hydrophobic regions of the molecule.

As we explore the solubility characteristics of this compound, it is essential to keep in mind that each factor can interact with others, leading to varying outcomes under different conditions. Ultimately, it encapsulates the fascinating interplay between structure and solubility, illustrating how the intricate design of a molecule can dictate its compatibility with various solvents.

Interesting facts

Interesting Facts about 2-[4-(2-naphthylsulfonylamino)phenyl]ethanehydroxamic acid

This fascinating compound, 2-[4-(2-naphthylsulfonylamino)phenyl]ethanehydroxamic acid, showcases a unique combination of functional groups that contributes to its biological significance. It is a synthetic derivative that has piqued the interest of chemists due to its potential therapeutic applications.

Here are some key highlights:

Anticancer Potential: Research has indicated that compounds related to hydroxamic acids can inhibit histone deacetylases (HDACs), a family of enzymes known to play a critical role in cancer progression.
Sulfonamide Group: The sulfonylamino moiety in this compound enhances its ability to interact with biological targets, providing important insights into drug design.
Structure-Activity Relationship (SAR): The intricate architecture of this compound, including the naphthalene and phenyl rings, lends itself well to studies aimed at expanding our understanding of how structural modifications can influence activity.

Interestingly, the hydroxamic acid functional group is renowned for its ability to chelate metal ions, which is not only valuable for therapeutic agents but also for applications in biochemistry and environmental science.

In summary, 2-[4-(2-naphthylsulfonylamino)phenyl]ethanehydroxamic acid is more than just a compound; it embodies the depth and complexity of organic chemistry, sparking curiosity for future research and applications. As scientists continue to explore its properties, we can expect to uncover even more about its potential in various fields, including medicinal chemistry and drug development.

Synonyms

HDInhib_000022

SCHEMBL8248238