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Pirfenidone

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Identification
Molecular formula
C10H11NO
CAS number
53179-13-8
IUPAC name
2-[4-(2-pyridyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone
State
State

At room temperature, Pirfenidone is found in a solid state. It is not soluble in water and has a slightly bitter taste.

Melting point (Celsius)
101.50
Melting point (Kelvin)
374.60
Boiling point (Celsius)
551.30
Boiling point (Kelvin)
824.50
General information
Molecular weight
271.35g/mol
Molar mass
271.3490g/mol
Density
1.1900g/cm3
Appearence

Pirfenidone is a white to pale yellow crystalline powder. It is well known in medical applications for the treatment of conditions like pulmonary fibrosis.

Comment on solubility

Solubility of 2-[4-(2-pyridyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone

The solubility of 2-[4-(2-pyridyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone can be quite intriguing due to its complex molecular structure. Understanding its solubility characteristics is crucial for applications in pharmaceuticals and other fields. Here are some key points to consider:

  • Polarity: The presence of both a piperazine and an aromatic ring suggests a degree of polarity, which may influence its solubility in various solvents.
  • Solvent Interaction: This compound is likely to exhibit differential solubility in:
    • Polar solvents: Such as water or methanol, where potential hydrogen bonding may enhance solubility.
    • Non-polar solvents: Like hexane or toluene, due to the hydrophobic aromatic groups, solubility may be lower.
  • pH Sensitivity: The nitrogen atoms in the pyridine and piperazine rings may also make the compound susceptible to changes in solubility with varying pH levels.
  • Temperature Dependence: Temperature can play a significant role; typically, solubility increases with temperature for solid compounds.

In summary, while specific solubility data for this compound may not be readily available, one can hypothesize that its solubility profile is governed by the interactions of its functional groups with different solvents, making empirical testing essential for accurate assessment. Experimentation is key!

Interesting facts

Exploring 2-[4-(2-pyridyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone

This fascinating compound, known for its unique structure and potential applications in medicinal chemistry, is an intriguing subject for scientists and students alike. Here are some notable aspects of 2-[4-(2-pyridyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone:

  • Diverse Pharmacological Potential: This compound has garnered attention in research due to its connection to various therapeutic areas, particularly in the realm of neuropharmacology. Many studies have suggested that it could influence serotonin receptors, potentially leading to treatments for mood disorders.
  • Structural Complexity: Its structure includes a piperazine ring and a pyridine moiety, making it a part of a broader class of compounds known as psychoactive agents. The presence of the trimethoxyphenyl group also adds to its chemical versatility, enabling interactions with multiple biological targets.
  • Research Tool: Researchers utilize this compound in various studies to understand the mechanisms of anxiety and depression. By exploring how it binds to specific receptors, scientists hope to illuminate the path for developing new, effective medications.
  • Chemical Synthesis: The synthesis of this compound is of interest in organic chemistry, as it showcases the application of modern synthetic techniques and methodologies that can yield complex molecules efficiently.
  • Historical Context: Compounds similar to this one have a rich history in drug discovery, particularly during the mid-20th century, when piperazine derivatives were extensively researched for their therapeutic effects.

As the field of medicinal chemistry continues to evolve, compounds like 2-[4-(2-pyridyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone remind us of the intricate connections between structure and function, presenting endless opportunities for discovery. Emphasizing the importance of continuing research and innovation in this area is essential for inspiring future generations of chemists.