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Piribedil dihydrochloride

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Identification
Molecular formula
C16H20Cl2N2O3
CAS number
522-51-0
IUPAC name
2-[4-(2-pyridyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone;dihydrochloride
State
State

At room temperature, Piribedil dihydrochloride is typically in a solid state.

Melting point (Celsius)
178.00
Melting point (Kelvin)
451.15
Boiling point (Celsius)
288.00
Boiling point (Kelvin)
561.15
General information
Molecular weight
385.29g/mol
Molar mass
385.2930g/mol
Density
1.2500g/cm3
Appearence

Piribedil dihydrochloride appears as a white to off-white crystalline powder, which is typical for many hydrochloride salts of organic compounds.

Comment on solubility

Solubility of 2-[4-(2-pyridyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone; dihydrochloride

The solubility of the compound 2-[4-(2-pyridyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone; dihydrochloride is an important aspect to consider due to its implications in pharmacological applications and formulation chemistry. Understanding its solubility profile can provide insights into its effectiveness and bioavailability.

The dihydrochloride salt form generally enhances solubility in aqueous environments compared to the free base. The following characteristics shape its solubility behavior:

  • Polarity: The presence of pyridyl and piperazine groups introduces significant polarity, which can facilitate solubility in polar solvents.
  • Hydrochloride Formation: The addition of hydrochloride groups tends to increase the compound's solubility in water, making it more favorable for pharmaceutical use.
  • Temperature Dependency: Solubility often improves with increasing temperature, thus influencing practical applications during formulation.
  • pH Sensitivity: Solubility may vary considerably at different pH levels, highlighting the importance of medium in which the compound is dissolved.

In summary, this compound is likely to exhibit good aqueous solubility due to its ionic and polar characteristics which are enhanced by the formation of the dihydrochloride salt. As we continuously study its interaction with various solvents, it's imperative to carry out empirical solubility tests for definitive conclusions.

Interesting facts

Interesting Facts about 2-[4-(2-pyridyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone; Dihydrochloride

This compound represents a fascinating example of organic chemistry, particularly in the realm of pharmaceutical design. It is noteworthy for its diverse potential applications, particularly in medicinal chemistry.

Key Features

  • Structure Complexity: The molecule features a combination of a piperazine ring, a pyridine ring, and a trimethoxyphenyl group. Such intricate structures often lead to enhanced biological activity.
  • Biological Activity: Compounds containing piperazine moieties are frequently studied for their influence on neurotransmitter receptors, potentially aiding in the treatment of various neurological conditions.
  • Research Applications: Due to its unique structure, this compound has been a subject of interest in research focused on developing new antidepressants or anxiolytics, showcasing the link between structure and function.

Implications in Medicine

The implications of this compound stretch into various areas of medicine:

  • Psychiatry: Its structural components suggest it may interact with serotonin or dopamine receptors, which are critical in mood regulation.
  • Cancer Research: Some derivatives of similar compounds are currently under investigation for their anticancer properties.
  • Drug Design: Understanding its synthesis and behavior can greatly influence the development of more effective drugs with reduced side effects.

In summary, 2-[4-(2-pyridyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone; dihydrochloride is not just a compound of interest for its synthetic route but also embodies the profound connection between chemical structure and biological activity. As chemists and researchers delve deeper into its potential, the compound may unveil new therapeutic potential and enhance our understanding of complex biological systems.

Synonyms
16785-32-3
ACETOPHENONE, 2-(4-(2-PYRIDYL)PIPERAZINYL)-3',4',5'-TRIMETHOXY-, DIHYDROCHLORIDE
1-(2-Pyridyl)-4-(3,4,5-trimethoxybenzoylmethyl)piperazine dihydrochloride
DTXSID20168414
2-(4-(2-Pyridyl)piperazinyl)-3',4',5'-trimethoxyacetophenone dihydrochloride
Piperazine, 1-(2-pyridyl)-4-(3,4,5-trimethoxybenzoylmethyl)-, dihydrochloride
DTXCID1090905
2-(4-Pyridin-2-ylpiperazin-1-yl)-1-(3,4,5-trimethoxyphenyl)ethanonedihydrochloride