Skip to main content

Diclofenac

ADVERTISEMENT
Identification
Molecular formula
C14H11Cl2NO2
CAS number
15307-86-5
IUPAC name
2-[4-(2,2-dichloroacetyl)anilino]-2-hydroxy-1-(4-methoxyphenyl)ethanone
State
State

Diclofenac is typically found in a solid state at room temperature.

Melting point (Celsius)
165.00
Melting point (Kelvin)
438.00
Boiling point (Celsius)
446.40
Boiling point (Kelvin)
719.60
General information
Molecular weight
318.13g/mol
Molar mass
318.1290g/mol
Density
1.4910g/cm3
Appearence

Diclofenac appears as a white to slightly yellowish crystalline powder. It is practically insoluble in water but soluble in organic solvents like methanol and ethanol.

Comment on solubility

Solubility of 2-[4-(2,2-dichloroacetyl)anilino]-2-hydroxy-1-(4-methoxyphenyl)ethanone

The solubility of the compound 2-[4-(2,2-dichloroacetyl)anilino]-2-hydroxy-1-(4-methoxyphenyl)ethanone can exhibit some interesting characteristics due to its complex molecular structure. Below are key aspects regarding its solubility:

  • Solvent Dependency: The solubility of this compound is likely to change significantly based on the solvent used. Generally, polar solvents tend to solvate compounds with similar polar characteristics.
  • Hydroxyl Group Influence: The presence of the hydroxyl (-OH) group can enhance solubility in polar solvents like water. This functionality can create hydrogen bonds with water molecules, improving solvation.
  • Chloroacetyl Group Effects: The dichloroacetyl group may also impact solubility. Its electron-withdrawing nature can influence the polarity of the entire molecule, potentially increasing interactions with polar environments.
  • Temperature Variability: Solubility often varies with temperature; hence, conducting solubility tests at elevated temperatures can provide further insights.

In contrast, its solubility in non-polar solvents might be limited due to the inherent polarity introduced by the functional groups. Therefore, it is essential to carefully select solvents for dissolution tests to ascertain its practical solubility profile.

In conclusion, while the solubility characteristics may not be universally defined, understanding the interaction between the compound's functional groups and various solvents allows for a deeper insight into its behavior in different environments.

Interesting facts

Interesting Facts about 2-[4-(2,2-Dichloroacetyl)anilino]-2-hydroxy-1-(4-methoxyphenyl)ethanone

This complex compound is an intriguing member of the class of organic chemicals known for their diverse applications and functionalities. Here are some fascinating aspects of this compound:

  • Pharmaceutical Significance: Compounds like this one often play a role in drug development. The presence of multiple functional groups suggests potential biological activity, which can be harnessed for therapeutic purposes.
  • Diverse Applications: This compound's unique structure allows it to serve in various fields, ranging from materials science to agrochemicals. The dichloroacetyl group, in particular, is known for enhancing lipophilicity, improving bioavailability in pharmaceutical applications.
  • Structure-Activity Relationship (SAR): Understanding how the specific arrangement of atoms in this compound affects its function can lead to design advancements in medicinal chemistry. Changes in the functional groups can significantly impact efficacy and safety.
  • Research Potential: Due to its intricate structure, this compound could be a subject of ongoing research in organic synthesis, leading to the discovery of new carbon-skeleton rearrangements or novel synthetic pathways.
  • Analytical Chemistry: The characterization of compounds like this one involves various analytical techniques such as NMR, IR spectroscopy, and mass spectrometry, making them crucial in the development of chemists' analytical skills.

In summary, 2-[4-(2,2-dichloroacetyl)anilino]-2-hydroxy-1-(4-methoxyphenyl)ethanone is not just a chemical entity but a potential gateway to advanced research and innovative applications in science. Its complex structure and functional diversity make it a captivating subject for both students and seasoned chemists alike.

Synonyms
BRN 2777017
2-((4-(Dichloroacetyl)phenyl)amino)-2-hydroxy-1-(4-methoxyphenyl)ethanone
27695-59-6
Ketone, 2-((4-(dichloroacetyl)phenyl)amino)-2-hydroxy-1-(4-methoxyphenyl)-
ETHANONE, 2-((4-(DICHLOROACETYL)PHENYL)AMINO)-2-HYDROXY-1-(4-METHOXYPHENYL)-
RefChem:341335
DTXSID90950363
2,2-Dichloro-1-(4-{[1-hydroxy-2-(4-methoxyphenyl)-2-oxoethyl]amino}phenyl)ethan-1-one