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Fezolamine

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Identification
Molecular formula
C20H16Cl2NO3S
CAS number
73515-24-5
IUPAC name
2-[4-(2,2-dichloroacetyl)anilino]-2-hydroxy-1-(4-phenylsulfanylphenyl)ethanone
State
State
Fezolamine is presented as a crystalline solid at room temperature, emphasizing its stable form in ordinary conditions. The compound is generally handled in its solid form for storage and experimental applications.
Melting point (Celsius)
187.50
Melting point (Kelvin)
460.65
Boiling point (Celsius)
480.20
Boiling point (Kelvin)
753.35
General information
Molecular weight
450.33g/mol
Molar mass
450.3340g/mol
Density
1.3988g/cm3
Appearence

Fezolamine is typically encountered as a solid. It is often found in a crystalline powder form that can vary from pale yellow to off-white color. The compound, due to its sulfur linkages and aromatic structure, may exhibit a distinctive smell similar to sulfides or thiols.

Comment on solubility

Solubility of 2-[4-(2,2-Dichloroacetyl)anilino]-2-hydroxy-1-(4-phenylsulfanylphenyl)ethanone

The solubility of 2-[4-(2,2-dichloroacetyl)anilino]-2-hydroxy-1-(4-phenylsulfanylphenyl)ethanone can be influenced by various factors due to its complex structure. Understanding its solubility in different solvents is essential for its application in both laboratory and industrial settings.

Factors Affecting Solubility

  • Polarity of the Solvent: This compound features both polar and nonpolar groups, which means it might be soluble in a mix of polar and nonpolar solvents.
  • Presence of Functional Groups: The hydroxyl group can engage in hydrogen bonding, potentially enhancing solubility in alcohols and water.
  • Nature of Substituents: The dichloroacetyl and phenyl sulfanyl groups can introduce steric hindrance that may affect solubility positively or negatively depending on the solvent used.

In general, one might anticipate that this compound could be moderately soluble in polar organic solvents like dimethyl sulfoxide (DMSO) or ethanol, while showing lower solubility in aqueous solutions. However, precise solubility data should be referred to or obtained experimentally for accurate insights.

Conclusion

Overall, the solubility of 2-[4-(2,2-dichloroacetyl)anilino]-2-hydroxy-1-(4-phenylsulfanylphenyl)ethanone is a complex interplay between its chemical structure and the chosen solvent. As such, it is prudent to approach its solubility with an understanding of the aforementioned factors.

Interesting facts

Interesting Facts About 2-[4-(2,2-Dichloroacetyl)anilino]-2-hydroxy-1-(4-phenylsulfanylphenyl)ethanone

This compound, known for its complex structure, showcases the fascinating intricacies of organic chemistry. Here are some engaging facets of this remarkable molecule:

  • Versatile Chemistry: The presence of both an amine and a sulfonyl group enhances its reactivity, paving the way for potential applications in synthetic organic chemistry.
  • Medical Potential: Given its unique molecular architecture, researchers are exploring its therapeutic properties, particularly in the fields of anti-cancer and anti-inflammatory drug development.
  • Dichloroacetyl Influence: The 2,2-dichloroacetyl group introduces significant electronic effects, making it a candidate for further modifications that can extend its utility in pharmaceuticals.
  • Intermolecular Interactions: The functionality in this compound allows for intriguing intermolecular interactions, potentially leading to unique physical and chemical properties.
  • Inhibition Mechanism: There is potential for this compound to act as an inhibitor in various biological pathways, with ongoing studies addressing its mechanism of action.

As with many complex compounds, understanding the interactions and properties of this molecule is an exciting challenge for chemists. Each component within its structure plays a pivotal role in dictating how the compound behaves in different environments. The journey of exploring such compounds leads to breakthroughs in both theoretical and applied chemistry.

Synonyms
BRN 2786244
2-((4-(Dichloroacetyl)phenyl)amino)-2-hydroxy-1-(4-(phenylthio)phenyl)ethanone
27700-43-2
Ketone, 2-((4-(dichloroacetyl)phenyl)amino)-2-hydroxy-1-(4-(phenylthio)phenyl)-
Ethanone, 2-((4-(dichloroacetyl)phenyl)amino)-2-hydroxy-1-(4-(phenylthio)phenyl)-
RefChem:341334
DTXSID80950377
2,2-Dichloro-1-[4-({1-hydroxy-2-oxo-2-[4-(phenylsulfanyl)phenyl]ethyl}amino)phenyl]ethan-1-one