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Fluphenazine

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Identification
Molecular formula
C22H26ClN3O4S
CAS number
69-23-8
IUPAC name
2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethyl 3,4,5-trimethoxybenzoate
State
State

At room temperature, Fluphenazine is in a solid state. It is stable under ordinary conditions of use and storage.

Melting point (Celsius)
258.00
Melting point (Kelvin)
531.15
Boiling point (Celsius)
616.10
Boiling point (Kelvin)
889.25
General information
Molecular weight
437.98g/mol
Molar mass
437.9790g/mol
Density
1.4530g/cm3
Appearence

Fluphenazine is typically a white to off-white crystalline powder. It is mostly odorless and looks like fine particles or aggregates of crystals under magnification.

Comment on solubility

Solubility of 2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethyl 3,4,5-trimethoxybenzoate

The solubility of the compound 2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethyl 3,4,5-trimethoxybenzoate can be quite complex due to its unique molecular structure and functional groups. Understanding its solubility characteristics is essential for its application and formulation. Here are some key points regarding its solubility:

  • Solvent Interaction: This compound may exhibit varying solubility in different solvents. It's generally more soluble in organic solvents compared to aqueous solutions.
  • Hydrophobic Nature: The presence of a phenothiazine moiety may contribute significantly to its hydrophobic characteristics, influencing its solubility in water.
  • Effect of Substituents: The trimethoxy groups on the benzoate moiety could enhance solubility in organic solvents, as they can participate in specific solvation interactions.
  • pH Dependence: The solubility might also be affected by the pH of the medium, especially if any of the functional groups can ionize.
  • Temperature Influence: Like many complex organic compounds, solubility may increase with an increase in temperature.

"Solubility is key to understanding how a compound can be utilized effectively in pharmaceutical and chemical applications."

In summary, the solubility of 2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethyl 3,4,5-trimethoxybenzoate is influenced by various factors and may require experimentation to fully characterize in potential applications.

Interesting facts

Interesting Facts about 2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethyl 3,4,5-trimethoxybenzoate

This compound is a fascinating example of how complex organic molecules can be utilized in medicinal chemistry. Its structure suggests a potential application in the treatment of various psychological and neurological disorders. Here are some key details:

  • Pharmacological Potential: The compound is derived from phenothiazine, which is a class of medications known for their antipsychotic properties. It is interesting how modifications to the basic phenothiazine structure can enhance its therapeutic effects.
  • Structure-Activity Relationship: The presence of piperazine and the ethyl chain plays a significant role in modifying the binding affinity of the compound to various neurotransmitter receptors, potentially affecting its efficacy and side effect profile.
  • Trimethoxybenzene Component: The 3,4,5-trimethoxybenzoate segment not only adds to the lipophilicity of the compound but also may influence its pharmacokinetics, allowing for better absorption and bioavailability.
  • Research Applications: Given its intricate design, researchers often explore such compounds for their potential to act as neuroleptics or in the treatment of mental health disorders, making them a subject of extensive pharmacological studies.

As a researcher in the field, one cannot help but appreciate the delicate balance between structure, activity, and therapeutic use.
In the words of a prominent chemist, "The beauty of medicinal chemistry lies in its ability to take a simple molecular framework and transform it into a powerful therapeutic agent."

Overall, 2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethyl 3,4,5-trimethoxybenzoate is not just a compound with a complex formula; it holds the promise of advancing our understanding and treatment of mental health conditions.

Synonyms
Metofenazate
Methophenazine
388-51-2
Metofenazato
Metofenazatum
Metofenazate [INN]
metophenazate
27J5OW8OGT
2-(4-(3-(2-Chlorophenothiazin-10-yl)propyl)-1-piperazinyl)ethyl 3,4,5-trimethoxybenzoate
2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethyl 3,4,5-trimethoxybenzoate
CHEBI:59116
Metofenazatum [INN-Latin]
Metofenazato [INN-Spanish]
2-{4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazin-1-yl}ethyl 3,4,5-trimethoxybenzoate
UNII-27J5OW8OGT
BRN 0773134
METOFENAZATE [MI]
1-Piperazineethanol, 4-(3-(2-chlorophenothiazin-10-yl)propyl)-, 3,4,5-trimethoxybenzoate
T 5
METOFENAZATE [WHO-DD]
SCHEMBL146144
CHEMBL2105229
DTXSID50192065
AAA38851
EX-A10636
MFCD00868179
AKOS003589077
Benzoic acid, 3,4,5-trimethoxy-, 2-(4-(3-(2-chlorophenothiazin-10-yl)propyl)-1-piperazinyl)ethyl ester
DA-75516
HY-100263
CS-0018414
NS00004158
Q4492673