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Zuclopenthixol

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Identification
Molecular formula
C22H25ClN2OS.C11H14O5
CAS number
53772-83-1
IUPAC name
2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethyl 3,4,5-trimethoxybenzoate;ethanesulfonic acid
State
State

At room temperature, zuclopenthixol is typically in a solid state.

Melting point (Celsius)
178.00
Melting point (Kelvin)
451.00
Boiling point (Celsius)
750.00
Boiling point (Kelvin)
1 023.00
General information
Molecular weight
586.10g/mol
Molar mass
586.0980g/mol
Density
1.3906g/cm3
Appearence

Zuclopenthixol is a white or almost white crystalline powder.

Comment on solubility

Solubility of 2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethyl 3,4,5-trimethoxybenzoate;ethanesulfonic acid

The solubility of a chemical compound is a crucial factor in its application and effectiveness, particularly in pharmaceuticals. When considering the solubility of 2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethyl 3,4,5-trimethoxybenzoate;ethanesulfonic acid, several aspects come into play:

  • Polarity: The presence of multiple functional groups, such as the trimethoxy groups and the piperazine moiety, suggests that the compound exhibits substantial polarity, which can enhance its solubility in polar solvents.
  • Acid-Base Interactions: The inclusion of ethanesulfonic acid indicates potential for strong ion-dipole interactions, which may facilitate solubility in aqueous environments.
  • Hydrophobicity: The 2-chlorophenothiazine component adds a hydrophobic character; this balance between hydrophobic and hydrophilic sections affects overall solubility.
  • Temperature Dependence: Like many compounds, solubility is likely to be temperature-dependent, often increasing with higher temperatures up to a certain limit.

Studies indicate that the solubility of this compound in water may not be extensive due to its complex structure, yet it might show good solubility in organic solvents or buffered solutions. Understanding its solubility profile is essential for effective formulation and bioavailability considerations.

Interesting facts

Interesting Facts about 2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethyl 3,4,5-trimethoxybenzoate;ethanesulfonic acid

This compound is a fascinating example of a complex pharmaceutical agent that merges elements of organic chemistry with medicinal applications. Here are some key points to consider:

  • Multifunctional Structure: The compound features a blend of a chlorophenothiazine moiety and a piperazine ring, which contributes to its pharmacological activity. The trifecta of methoxy groups enhances its lipophilicity, facilitating better biological interactions.
  • Pharmaceutical Relevance: Compounds like this are often investigated for their potential therapeutic roles, particularly in psychiatric disorders and as antipsychotics. The inclusion of piperazine units is common in many antidepressants and antipsychotic medications, indicating possible analgesic properties.
  • Chlorine Significance: The chlorophenothiazine structure often correlates with heightened therapeutic efficacy and varied side effect profiles. The presence of chlorine atoms can significantly influence the behavior of the compound in biological systems.
  • Synthesis & Modification: Researchers constantly seek to optimize such compounds through structural modifications to enhance their effectiveness and reduce adverse effects. This compound exemplifies how small chemical changes can influence biological activity.
  • Complex Interactions: The ethyl ester and sulfonic acid components suggest this compound may interact with various biological pathways, potentially offering unique mechanisms of action within the central nervous system.

Overall, the study of 2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethyl 3,4,5-trimethoxybenzoate;ethanesulfonic acid underscores the intricate relationship between chemical structure and biological function in pharmacology. As science continues to unravel the complexities of such compounds, the potential for innovative therapeutic solutions remains an exciting frontier in the field!

Synonyms
Methophenazine diethanesulfonate
Metofenazate diesylate
UNII-YM9W99502E
YM9W99502E
DTXSID30168283
BENZOIC ACID, 3,4,5-TRIMETHOXY-, 2-(4-(3-(2-CHLORO-10H-PHENOTHIAZIN-10-YL)PROPYL)-1-PIPERAZINYL)ETHYL ESTER, ETHANESULFONATE (1:2)
DTXCID8090774
1674-48-2
Benzoic acid, 3,4,5-trimethoxy-, 2-(4-(3-(2-chlorophenothiazin-10-yl)propyl)-1-piperazinyl)ethyl ester, diethanesulfonate
Metofenazate diethanesulfonate
EX-A10637
Q27294589