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Clopenthixol dihydrochloride

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Identification
Molecular formula
C21H25ClNOS.C2H4Cl2
CAS number
3546-21-8
IUPAC name
2-[4-[3-(2-chlorothioxanthen-9-ylidene)propyl]piperazin-1-yl]ethanol;dihydrochloride
State
State

At room temperature, Clopenthixol dihydrochloride is a solid. It is stable under normal conditions and should be stored in a cool, dry place to preserve its integrity.

Melting point (Celsius)
234.00
Melting point (Kelvin)
507.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
478.38g/mol
Molar mass
478.3750g/mol
Density
1.3500g/cm3
Appearence

Clopenthixol dihydrochloride typically appears as a crystalline powder. It is characterized by its yellowish or off-white color, depending on its purity and storage conditions.

Comment on solubility

Solubility of 2-[4-[3-(2-chlorothioxanthen-9-ylidene)propyl]piperazin-1-yl]ethanol;dihydrochloride

The solubility of 2-[4-[3-(2-chlorothioxanthen-9-ylidene)propyl]piperazin-1-yl]ethanol;dihydrochloride can be quite interesting due to its complex nature. This compound, being a dihydrochloride salt, is generally expected to display a higher solubility in polar solvents, particularly water. Here are some key points regarding its solubility:

  • Polar Solubility: Dihydrochloride salts, like this compound, often dissolve well in aqueous solutions due to their ability to ionize and form charged species.
  • Non-Polar Solvents: Solubility in non-polar solvents is likely to be limited. Compounds containing significant amounts of nitrogen and chlorine tend to favor polar interactions.
  • Temperature Dependency: As seen with many chemical compounds, the solubility might increase with temperature, allowing for greater dissolution rates in warmer solvents.
  • pH Sensitivity: The solubility can also be affected by the pH of the solution; acidic conditions may promote the solubility of the salt by preventing precipitation.

In summary, this compound's solubility characteristics highlight its compatibility with polar environments, showcasing the significant impact of ionic properties and environmental conditions on its dissolution behavior. As always, experimental determination of solubility is recommended to obtain precise values under specific conditions.

Interesting facts

Interesting Facts about 2-[4-[3-(2-chlorothioxanthen-9-ylidene)propyl]piperazin-1-yl]ethanol; dihydrochloride

This compound, known for its complex structure and intriguing properties, has a variety of applications in scientific research and medicinal chemistry. Below are some noteworthy aspects:

  • Versatile Applications: This compound is widely studied for its potential in treating various neuropsychiatric disorders due to its interactions with neurotransmitter pathways.
  • Unique Structure: The presence of the thioxanthen moiety gives this compound unique chemical properties, including strong π-π stacking interactions, which can enhance its efficacy as a therapeutic agent.
  • Piperazine Derivative: The incorporation of the piperazine ring is significant, as compounds with this structure often exhibit improved pharmacological profiles and selectivity towards specific receptors.
  • Chlorine Substitution: The 2-chloro substitution enhances lipophilicity, allowing the compound to cross biological membranes more effectively, which is crucial in drug development.
  • Research Potential: Due to its complex mechanism of action and potential for modifying behavior in model organisms, this compound garners attention in neuropharmacology and behavioral studies.

As scientists continue to investigate the properties and efficacy of this compound, it stands as a testament to the intricate relationship between chemical structure and biological function. Innovations in synthetic methods and modifications of this compound may pave the way for novel therapeutic agents and contribute to the broader understanding of psychoactive substances.


Synonyms
DTXSID60110058
Clopenthixol dihydrochloride
DTXCID9065318
CLOPENTHIXOL DIHYDROCHLORIDE [MI]
alpha-Clopenthixol dihydrochloride
2-[4-[3-(2-chlorothioxanthen-9-ylidene)propyl]piperazin-1-yl]ethanol;dihydrochloride
SCHEMBL935397
BCP11695
2-[4-[(3Z)-3-(2-chlorothioxanthen-9-ylidene)propyl]piperazin-1-yl]ethanol dihydrochloride
DS-012841
NS00079576
Trans-Clopenthixol Dihydrochloride; Beta-Clopenthixol dihydrochloride pound>>Clopenthixol dihydrochloride