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Trifluoperazine

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Identification
Molecular formula
C21H24F3N3OS
CAS number
117-89-5
IUPAC name
2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]-1,4-diazepan-1-yl]ethanol
State
State

At room temperature, trifluoperazine is in a solid state, presenting as a stable compound under standard conditions.

Melting point (Celsius)
242.00
Melting point (Kelvin)
515.15
Boiling point (Celsius)
348.90
Boiling point (Kelvin)
622.05
General information
Molecular weight
480.50g/mol
Molar mass
480.4400g/mol
Density
1.3660g/cm3
Appearence

Trifluoperazine typically appears as a light yellow crystalline powder. It is odorless and known for its distinct crystalline form.

Comment on solubility

Solubility of 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]-1,4-diazepan-1-yl]ethanol

The solubility of the compound 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]-1,4-diazepan-1-yl]ethanol can be influenced by several factors, reflecting its complex structure. Below are some key points to consider regarding its solubility:

  • Polarity: The presence of both hydrophilic (alcohol -OH group) and hydrophobic (phenothiazine moiety and trifluoromethyl group) characteristics suggests that this compound may have variable solubility in different solvents.
  • Solvent Interaction: It is expected to exhibit good solubility in polar solvents such as water and ethanol, while its interactions with non-polar solvents may be less favorable.
  • Temperature Influence: Solubility can be significantly affected by temperature; increasing the temperature may enhance the solubility in polar solvents.
  • pH Dependency: Since this compound contains an alcohol group, its solubility might vary with pH changes, highlighting the necessity for consideration of solvent’s pH in practical applications.

In summary, *the solubility of 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]-1,4-diazepan-1-yl]ethanol is multifaceted*, highly dependent on the nature of the solvent and environmental conditions.
Further experimental studies are recommended to determine the exact solubility characteristics for this intriguing compound.

Interesting facts

Interesting Facts about 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]-1,4-diazepan-1-yl]ethanol

This intriguing compound is part of a class of chemicals known for their pharmaceutical relevance, particularly in the realm of psychiatry. With a complex structure, it boasts numerous functional groups that contribute to its activity.

Key Features

  • Therapeutic Uses: Derivatives of this compound class are often researched for their potential application as antipsychotic agents, showcasing their importance in treating mental health conditions.
  • Fluorinated Structure: The presence of the trifluoromethyl group is noteworthy; it can enhance lipophilicity, contributing to the compound’s absorption and distribution in biological systems.
  • Interactions: The phenothiazine moiety is known to interact with various neurotransmitter receptors, playing a crucial role in modifying synaptic transmission.
  • Central Nervous System Effects: Compounds with similar structures have been associated with significant effects on the central nervous system, making them valuable subjects of study for understanding brain chemistry.

In the field of medicinal chemistry, compounds like this one are celebrated for their ability to undergo various chemical transformations, enhancing their pharmacological profiles. As a budding chemist or scientist, one might explore its synthesis, mechanism of action, and potential side effects to gain a comprehensive understanding of its role in modern medicine.

Quote to Ponder

"Chemistry is the ability to take something ordinary and create something extraordinary." – An anonymous quote that beautifully captures the essence of what compounds like 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]-1,4-diazepan-1-yl]ethanol represent in the context of drug discovery and development.

This compound exemplifies the intricate relationship between structure and function in medicinal chemistry, inviting further exploration and discovery.

Synonyms
HOMOFENAZINE
Homofenazina
Homofenazinum
3833-99-6
Homofenazine [INN]
Homofenazin
Homophenazine
D-775
PEL7G6VRZ2
CHEBI:59071
2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]-1,4-diazepan-1-yl]ethanol
Hexahydro-4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)-1H-1,4-diazepine-1-ethanol
HFZ
D 775
Hexahydro-4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)-1H-1,4-diazepin-1-ethanol
UNII-PEL7G6VRZ2
HOMOFENAZINE [MI]
HOMOFENAZINE [WHO-DD]
SCHEMBL1643422
CHEMBL2105000
DTXSID30191697
LOHNHQLZFYCAEQ-UHFFFAOYSA-N
2-Trifluoroethyl-10-(3-(4-(beta-hydroxyethyl-1-hexahydro-1,4-diazepinyl)propyl)phenothiazine
Hexahydro-4-(3-(2-trifluoromethyl)phenothiazin-10-yl)propyl)-1H-1,4-diazepin-1-ethanol
NS00001046
Q27126439
1-(2-HYDROXYETHYL)-4-(3-(3-TRIFLUOROMETHYLPHENOTHIAZIN-10-YL)PROPYL)HOMOPIPERAZINE
2-(4-{3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl}-1,4-diazepan-1-yl)ethanol
3-TRIFLUOROMETHYL-10-(3-(4-(2-HYDROXYETHYL)HOMOPIPERAZINO)PROPYL)PHENOTHIAZINE
1-(.BETA.-HYDROXYETHYL)-4-(3-(2-TRIFLUOROMETHYLPHENOTHIAZIN-10-YL)PROPYL)HEXAHYDRO-1,4-DIAZEPINE
2-(4-{3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl}-1,4-diazepan-1-yl)ethan-1-ol