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Trifluoperazine

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Identification
Molecular formula
C21H24F3N3O2S
CAS number
117-89-5
IUPAC name
2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl N,N-dimethylcarbamate
State
State

At room temperature, trifluoperazine is typically encountered as its hydrochloride form, which is a solid. Due to its pharmaceutical nature, it is often supplied in formulated tablets or capsules for therapeutic use.

Melting point (Celsius)
258.00
Melting point (Kelvin)
531.15
Boiling point (Celsius)
441.50
Boiling point (Kelvin)
714.65
General information
Molecular weight
480.44g/mol
Molar mass
480.4440g/mol
Density
1.2578g/cm3
Appearence

Trifluoperazine is typically found in the form of its hydrochloride salt, which appears as a white to off-white crystalline powder. The compound is sensitive to light and should be stored in a light-resistant container to maintain its stability.

Comment on solubility

Solubility of 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl N,N-dimethylcarbamate

The solubility of 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl N,N-dimethylcarbamate is influenced by its complex molecular structure and functional groups. Here are some key points to consider:

  • Polar vs. Nonpolar: The presence of both polar and nonpolar characteristics in its structure can lead to varying solubility in different solvents.
  • Common Solvents: This compound may exhibit solubility in organic solvents such as methanol, ethanol, and dimethyl sulfoxide (DMSO), due to the presence of polar functional groups.
  • Water Solubility: Limited water solubility is likely, considering the larger hydrophobic phenothiazine portion of the molecule which tends to resist hydration.
  • Environmental Impact: The trifluoromethyl group could also affect solubility, potentially enhancing lipophilicity and reducing overall solubility in aqueous environments.

In conclusion, the solubility of this compound is a balance of its intricate structural features. While it may dissolve well in certain organic solvents, its interaction with water is significantly hindered due to its hydrophobic sections. As a result, understanding these solubility properties is crucial for its application in various fields.

Interesting facts

Exploring 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl N,N-dimethylcarbamate

This intriguing compound is a member of the class of chemical compounds known as carbamates, which play a crucial role in various applications within organic chemistry and pharmaceuticals. Its unique structure, featuring a trifluoromethyl group attached to a phenothiazine derivative, imbues it with distinctive properties that are of significant interest to chemists.

Key Points of Interest:

  • Pharmacological Potential: Many compounds similar to this one exhibit significant biological activity, making them key targets in drug development. The phenothiazine backbone is particularly noted for its antipsychotic properties and can influence neurotransmitter receptors, which may lead to novel therapeutic applications.
  • Fluorine Chemistry: The incorporation of fluorine atoms into organic structures can greatly enhance their biological properties. The trifluoromethyl group is known for improving metabolic stability and bioavailability, which are essential factors in the efficacy of pharmaceutical agents.
  • Structural Complexity: The intricate multi-ring structure, including a piperazine and carbamate moiety, showcases the diversity possible in organic synthesis. The design of this compound highlights the creativity involved in modern synthetic chemistry.
  • Potential Applications: Besides medicinal chemistry, carbamates are prevalent in pesticides and insecticides, demonstrating the versatility of this functional group in various fields.

In conclusion, the investigation of compounds like 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl N,N-dimethylcarbamate opens new avenues in the search for potent treatments and understanding complex chemical interactions. As one knowledgeable chemist aptly stated, "The beauty of chemistry lies in the endless possibilities of transformation and discovery."