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Flupentixol dihydrochloride

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Identification
Molecular formula
C23H25ClF3NOS2
CAS number
51529-01-2
IUPAC name
2-[4-[3-[2-(trifluoromethyl)thioxanthen-9-ylidene]propyl]piperazin-1-yl]ethanol;dihydrochloride
State
State
Flupentixol dihydrochloride is typically in a solid state at room temperature, specifically as a crystalline powder. It is generally considered stable under normal storage conditions.
Melting point (Celsius)
235.00
Melting point (Kelvin)
508.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
505.45g/mol
Molar mass
505.4490g/mol
Density
1.3900g/cm3
Appearence

Flupentixol dihydrochloride appears as a crystalline powder that is usually off-white to pale yellow in color. It is hygroscopic, meaning it has a tendency to absorb moisture from the air. Its crystalline nature can vary slightly based on environmental conditions such as humidity and temperature.

Comment on solubility

Solubility of 2-[4-[3-[2-(trifluoromethyl)thioxanthen-9-ylidene]propyl]piperazin-1-yl]ethanol; dihydrochloride

The solubility of 2-[4-[3-[2-(trifluoromethyl)thioxanthen-9-ylidene]propyl]piperazin-1-yl]ethanol; dihydrochloride can be assessed based on various factors influenced by its chemical structure and the presence of ionic components. Here are some key considerations:

  • Ionic Nature: As a dihydrochloride salt, this compound is likely to exhibit significant solubility in polar solvents like water, due to the ion-dipole interactions between water molecules and the charged species.
  • Hydrophobic Regions: The presence of the trifluoromethyl group and thioxanthen structure may introduce hydrophobic characteristics, potentially impacting solubility in non-polar solvents.
  • pH Dependence: Solubility may vary with pH, particularly for compounds with basic or acidic functional groups, thereby enhancing solubility at specific pH levels.
  • Temperature Effects: Like many substances, solubility can increase with temperature; thus, heating the solvent may assist in dissolving the compound more effectively.

Overall, while the dihydrochloride form suggests a good level of solubility in aqueous environments due to its ionic composition, the precise solubility profile will depend on the balance of hydrophilic and hydrophobic characteristics inherent to its complex structure. As stated, “the solubility of a compound is a delicate dance between its molecular interactions and the solvent used.” Therefore, experimental validation in various solvents is advised to accurately determine its solubility behavior.

Interesting facts

Interesting Facts about 2-[4-[3-[2-(trifluoromethyl)thioxanthen-9-ylidene]propyl]piperazin-1-yl]ethanol; dihydrochloride

This fascinating compound belongs to a class of chemicals known for their structural complexity and potential therapeutic applications. Here are some key highlights:

  • Unique Structure: The compound features a thioxanthenylidene moiety, which adds considerable complexity and can influence its interaction with biological systems.
  • Fluorinated Component: The presence of a trifluoromethyl group enhances the lipophilicity of the compound, affecting its pharmacokinetic properties, such as absorption and distribution in the body.
  • Versatile Applications: Due to its piperazine nitrogen base, this compound may show promise as a pharmacological agent, particularly in the fields of psychiatry and neurology.
  • Research Potential: The compound might serve as a lead structure in drug discovery, especially for conditions that involve dopaminergic and serotonergic pathways.
  • Mechanistic Insights: Studies could explore its action mechanisms through receptor affinity and the modulation of neurotransmitter systems, contributing to our understanding of complex mental health disorders.

As we dive deeper into the world of organic synthesis and medicinal chemistry, this compound illustrates the intricate relationship between chemical structure and biological activity. Its unique attributes make it an interesting subject for further research.

Synonyms
cis-(Z)-Flupentixol Dihydrochloride
Fupentixol dihydrochloride
piperazineethanol dihydrochloride
thioxanthen-9-ylidene]propyl]-1-
(Z)-flupentixol dihydrochloride
(E/Z)-Fupentixol
|A-Flupenthixol Hydrochloride
(E/Z)-Fupentixol Dihydrochloride
BCP09435
BCP12120
AKOS024457954
(Z)-4-[3-[2-(Trifluoromethyl)-9H-
Flupenthixol dihydrochloride,4-[3-[2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-1-piperazineethanoldihydrochloride
4528B
NS00082966