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Folinic Acid

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Identification
Molecular formula
C20H23N7O7
CAS number
58-05-9
IUPAC name
2-[[4-[3-(2,6-diamino-4-oxo-1H-pyrimidin-5-yl)propyl-[2-[2-oxo-2-(4-phosphonooxybutylamino)ethyl]sulfanylacetyl]amino]benzoyl]amino]pentanedioic acid
State
State

At room temperature, folinic acid is typically found as a solid powder. It is stable under normal conditions but should be stored in a cool, dry place to maintain its integrity, especially due to its hygroscopic nature.

Melting point (Celsius)
250.00
Melting point (Kelvin)
523.15
Boiling point (Celsius)
775.90
Boiling point (Kelvin)
1 049.05
General information
Molecular weight
473.49g/mol
Molar mass
473.4900g/mol
Density
1.6700g/cm3
Appearence

Folinic acid typically appears as a yellow or off-white crystalline powder. It is hygroscopic, meaning it can absorb moisture from the environment, which might alter its appearance slightly if not stored properly. The powder is often used in its reconstituted form for pharmaceutical applications.

Comment on solubility

Solubility of 2-[[4-[3-(2,6-diamino-4-oxo-1H-pyrimidin-5-yl)propyl-[2-[2-oxo-2-(4-phosphonooxybutylamino)ethyl]sulfanylacetyl]amino]benzoyl]amino]pentanedioic acid

The solubility of this complex compound, C20H23N7O7, can be influenced by various factors, owing to its intricate structure and multiple functional groups. It can be categorized as follows:

  • Nature of Functional Groups: The presence of polar functional groups such as amino, carboxylic acid, and phosphonic acid moieties tends to enhance solubility in polar solvents, particularly in water.
  • Hydrophobic Regions: The compound also contains hydrophobic segments, which may limit its solubility in strictly polar solvents, indicating a balanced nature.
  • pH Dependency: Solubility can be highly pH-dependent due to the ionizable groups present, which may enhance solubility in slightly acidic to neutral conditions.
  • Temperature Effects: Increased temperature can potentially improve solubility by enhancing molecular interactions, although specific data for this compound may be lacking.

Overall, while the complex nature of this molecule suggests potential solubility in polar environments, it is essential to conduct empirical studies to determine practical solubility limits under various conditions. "Understanding solubility is key to unlocking the potential uses of any compound!" This is especially true for compounds that integrate such diverse functional components as this one.

Interesting facts

Interesting Facts about 2-[[4-[3-(2,6-diamino-4-oxo-1H-pyrimidin-5-yl)propyl-[2-[2-oxo-2-(4-phosphonooxybutylamino)ethyl]sulfanylacetyl]amino]benzoyl]amino]pentanedioic acid

This compound is a fascinating member of the vast world of organic chemistry, particularly known for its complex structure and potential therapeutic applications. Here are some notable insights:

  • Multi-functional Nature: The compound showcases multiple functional groups, including amino, carbonyl, and phosphonate groups, making it a versatile candidate for drug design.
  • Potential Antitumor Activity: Its structural components suggest potential relevance in oncology, particularly due to the presence of pyrimidine and amino acid derivatives.
  • Role in Antimetabolites: The heavy influence of amino and keto groups in the structure indicates that this compound might act as an antimetabolite, which is fundamental in cancer treatment.
  • Phosphonate Group: The phosphonates found in compounds often enhance the biological activity and can improve the stability of the molecule, contributing to its potential as a pharmaceuticals candidate.
  • Structure-Activity Relationship (SAR): Researchers often study compounds like this one to understand how slight changes in structure can lead to significant variations in biological activity, which is crucial for developing effective medications.

In summary, 2-[[4-[3-(2,6-diamino-4-oxo-1H-pyrimidin-5-yl)propyl-[2-[2-oxo-2-(4-phosphonooxybutylamino)ethyl]sulfanylacetyl]amino]benzoyl]amino]pentanedioic acid serves as a prime example of how intricate chemical compositions hold the key to advancing medicinal chemistry and potentially discovering novel therapies for various diseases.