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Diclofenac

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Identification
Molecular formula
C14H11ClNO2
CAS number
15307-86-5
IUPAC name
2-[4-(3-chloro-4-methoxy-phenyl)phenyl]acetic acid
State
State
Diclofenac is in solid state at room temperature, typically found as a crystalline powder.
Melting point (Celsius)
165.00
Melting point (Kelvin)
438.15
Boiling point (Celsius)
295.00
Boiling point (Kelvin)
568.15
General information
Molecular weight
296.15g/mol
Molar mass
296.1480g/mol
Density
1.5940g/cm3
Appearence
Diclofenac appears as a white to slightly yellow, odorless, crystalline powder.
Comment on solubility

Solubility of 2-[4-(3-chloro-4-methoxy-phenyl)phenyl]acetic acid

The solubility of 2-[4-(3-chloro-4-methoxy-phenyl)phenyl]acetic acid in various solvents can be influenced by several factors, including molecular structure and intermolecular interactions. This compound features a carboxylic acid functional group, which typically enhances solubility in polar solvents.

Key points regarding its solubility:

  • Polar solvents: Generally, compounds with carboxylic acid groups tend to be highly soluble in water and other polar solvents due to hydrogen bonding capabilities.
  • Non-polar solvents: The presence of aromatic rings in the molecule may lead to decreased solubility in non-polar solvents, as the molecule will not effectively interact with non-polar environments.
  • pH dependence: The solubility can also change with pH, as the ionization of the acid group may vary, making it more soluble in alkaline conditions when deprotonated.
  • Temperature effects: Increased temperatures often enhance solubility, allowing for better dissolution in various solvents.

In summary, while 2-[4-(3-chloro-4-methoxy-phenyl)phenyl]acetic acid is expected to show appreciable solubility in polar solvents, its actual behavior should be evaluated contextually, taking into account both the solvent choice and environmental conditions. As the saying goes, “like dissolves like,” emphasizing the need to match polarities for optimal solubility.

Interesting facts

Interesting Facts about 2-[4-(3-chloro-4-methoxy-phenyl)phenyl]acetic acid

2-[4-(3-chloro-4-methoxy-phenyl)phenyl]acetic acid, often abbreviated in scientific literature for convenience, is a fascinating compound with significant implications in various fields of chemistry and pharmacology. Here are some interesting highlights:

  • Pharmaceutical Relevance: This compound belongs to the class of non-steroidal anti-inflammatory drugs (NSAIDs), which are widely used for their therapeutic properties in alleviating pain and inflammation.
  • Structure-Activity Relationship: The intricate molecular structure of this compound showcases the importance of precise functional groups in delivering specific biological activities.
  • Mechanism of Action: Compounds like this one typically work by inhibiting cyclooxygenase (COX) enzymes, which are pivotal in the biosynthesis of prostaglandins—hormone-like substances involved in inflammation and pain pathways.
  • Chlorine’s Role: The presence of the chlorine atom in its structure is not merely incidental; it significantly influences the compound's binding affinity and stability, enhancing its pharmacological efficacy.
  • Research Potential: Ongoing studies continue to explore the compound’s potential as a lead molecule for developing more potent and selective drugs, targeting various inflammatory disorders and conditions.

This compound serves as an excellent example for students and researchers alike, demonstrating how small structural modifications can lead to significant changes in biological activity. As you delve further into the world of organic chemistry and medicinal applications, keep an eye on compounds like 2-[4-(3-chloro-4-methoxy-phenyl)phenyl]acetic acid; their complexities and applications are endless!

Synonyms
17027-67-7
4-BIPHENYLACETIC ACID, 3'-CHLORO-4'-METHOXY-
BRN 2655097
2-(4-(3'-Chloro-4'-methoxy)biphenylyl)acetic acid
[1,1'-Biphenyl]-4-aceticacid, 3'-chloro-4'-methoxy-
DTXSID30168824