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Foramidine

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Identification
Molecular formula
C14H23N10O4
CAS number
50-48-6
IUPAC name
2-[[4-[[4-[(4-formamido-1-methyl-imidazole-2-carbonyl)amino]-1-methyl-imidazole-2-carbonyl]amino]-1-methyl-imidazole-2-carbonyl]amino]ethyl-dimethyl-ammonium
State
State

At room temperature, foramidine is usually a solid.

Melting point (Celsius)
192.50
Melting point (Kelvin)
465.70
Boiling point (Celsius)
486.50
Boiling point (Kelvin)
759.70
General information
Molecular weight
376.41g/mol
Molar mass
376.4050g/mol
Density
1.2400g/cm3
Appearence

Foramidine is typically found as a white crystalline solid.

Comment on solubility

Solubility of 2-[[4-[[4-[(4-formamido-1-methyl-imidazole-2-carbonyl)amino]-1-methyl-imidazole-2-carbonyl]amino]-1-methyl-imidazole-2-carbonyl]amino]ethyl-dimethyl-ammonium (C14H23N10O4)

The solubility profile of this complex compound is quite intriguing, considering its multifaceted structure. The presence of multiple functional groups such as amido and amino typically contributes to solubility in polar solvents, particularly in aqueous environments. However, several factors can affect this solubility:

  • Polarity: The extensive network of nitrogen atoms in the structure suggests a high level of polarity, which usually favors solubility in water.
  • Hydrogen Bonding: The ability of the compound to participate in hydrogen bonding can enhance its interaction with solvents, further promoting solubility.
  • Size and Steric Hindrance: The relatively large size of the molecule may introduce steric hindrance, potentially restricting its solubility in certain solvents.
  • pH Dependence: As with many ammonium compounds, solubility may vary significantly with changes in pH, influencing the ionization states.

In summary, while the detailed solubility of this compound can vary based on specific conditions, it is likely to exhibit reasonable solubility in polar, protic solvents due to the presence of functional groups that promote interaction with such environments. Consequently, the overall solubility will be a product of the interplay of polarity, hydrogen bonding capabilities, size, and pH sensitivity.

Interesting facts

Interesting Facts about 2-[[4-[[4-[(4-formamido-1-methyl-imidazole-2-carbonyl)amino]-1-methyl-imidazole-2-carbonyl]amino]-1-methyl-imidazole-2-carbonyl]amino]ethyl-dimethyl-ammonium

This compound, often referred to by its structural components rather than a simple trivial name, is a fascinating example of complex molecular architecture in medicinal chemistry. Here are some key points that highlight its significance:

  • Biological Relevance: The presence of multiple imidazole rings suggests potential biological activity, as imidazole is known for its role in numerous biological systems, including enzyme active sites and as a part of many pharmaceutical compounds.
  • Amidation: The incorporation of formamido groups indicates that this compound may participate in hydrogen bonding interactions, which are crucial for biological activity, potentially affecting its pharmacodynamics and pharmacokinetics.
  • Quaternization: The dimethylammonium group introduces a positive charge, which can enhance solubility in biological systems, typically making it more bioavailable and aiding in its interaction with biological membranes.
  • Multi-functional Potential: The intricate structure allows for various modifications. Chemists can explore altering specific groups to tailor the compound's properties for specific therapeutic targets, showcasing the compound's versatility.

A quote from renowned chemist Linus Pauling encapsulates the essence of such compounds: "The best way to have a good idea is to have lots of ideas." This emphasizes the potential for innovation inherent in the study of complex molecules like this one.

Overall, this compound is not just a representation of chemical complexity but may also embody potential solutions to challenges in drug discovery and development, illustrating the intricate ballet between structure and function in biochemistry.

Synonyms
AR1
(2-{[4-({4-[(4-FORMYLAMINO-1-METHYL-1H-IMIDAZOLE-2-CARBONYL)-AMINO]-1-METHYL-1H-IMIDAZOLE-2-CARBONYL}-AMINO)-1-METHYL-1 H-IMIDAZOLE-2-CARBONYL]-AMINO}-ETHYL)-DIMETHYL-AMMONIUM
(2-{[4-({4-[(4-formylamino-1-methyl-1h-imidazole-2-carbonyl)-amino]-1-methyl-1h-imidazole-2-carbonyl}-amino)-1-methyl-1h-imidazole-2-carbonyl]-amino}-ethyl)-dimethyl-ammonium
Q27457863
TRI-IMIDAZOLE DNA MINOR GROOVE BINDER; AR-1-144
H-IMIDAZOLE-2-CARBONYL]-AMINO}-ETHYL)-DIMETHYL-AMMONIUM
(2-{[4-({4-[(4-FORMYLAMINO-1-METHYL-1H-IMIDAZOLE-2-CARBONYL)-AMINO]-1-METHYL-1H-IMIDAZOLE-2-CARBONYL}-AMINO)-1-METHYL-1
2-({[4-({[4-({[4-(formylamino)-1-methyl-1H-imidazol-2-yl]carbonyl}amino)-1-methyl-1H-imidazol-2-yl]carbonyl}amino)-1-methyl-1H-imidazol-2-yl]carbonyl}amino)-N,N-dimethylethanaminium