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Tropisetron

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Identification
Molecular formula
C17H20ClNO2
CAS number
105826-92-4
IUPAC name
2-[4-(4-chlorophenyl)butyl]-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium;2-hydroxy-2-oxo-acetate
State
State

At room temperature, tropisetron typically exists as a solid. In its pure form or as a salt, it is stable under recommended storage conditions.

Melting point (Celsius)
139.00
Melting point (Kelvin)
412.15
Boiling point (Celsius)
493.90
Boiling point (Kelvin)
767.05
General information
Molecular weight
325.83g/mol
Molar mass
325.8280g/mol
Density
1.3114g/cm3
Appearence

Tropisetron appears as a white to almost-white crystalline powder. It is commonly supplied in its hydrochloride salt form for medicinal use, which is generally a crystalline solid as well.

Comment on solubility

Solubility of 2-[4-(4-chlorophenyl)butyl]-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium;2-hydroxy-2-oxo-acetate

The solubility of the compound 2-[4-(4-chlorophenyl)butyl]-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium;2-hydroxy-2-oxo-acetate is influenced by several factors, including its unique structural features and the presence of functional groups.

Factors Affecting Solubility:

  • Polarity: The polar nature of the 2-hydroxy-2-oxo-acetate component likely enhances its solubility in polar solvents such as water.
  • Hydrophobic Regions: The presence of the butyl and chlorophenyl groups may introduce hydrophobic characteristics, affecting overall solubility in aqueous environments.
  • Hydrogen Bonding: The hydroxyl functional group can form hydrogen bonds with solvents, further promoting solubility.

In general, compounds with a balance of polar and hydrophobic regions tend to exhibit variable solubility:

  • Water Solubility: Potentially soluble due to polar hydroxyl and methoxy groups.
  • Organic Solvents: May show higher solubility in organic solvents due to the hydrophobic regions.

Overall, the solubility of this compound is expected to be complex, depending on the solvent and conditions. Further empirical studies would provide precise insights into its solubility profile under different circumstances.

Interesting facts

Interesting Facts about 2-[4-(4-chlorophenyl)butyl]-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium; 2-hydroxy-2-oxo-acetate

This fascinating compound is part of a broader class of molecules known as isoquinolines, which are structures associated with a variety of biological activities. Isoquinolines and their derivatives have been subjects of interest in medicinal chemistry primarily due to their alkaloidal properties and potential therapeutic effects.

Key Features:

  • Diverse Applications: Many isoquinoline derivatives are explored for their roles in treating ailments such as cancer, cardiovascular diseases, and neurological disorders.
  • Pharmacological Insights: The specific substituent groups present in this compound, such as the 4-chlorophenyl butyl moiety, can significantly influence its biological activity, enhancing its modulating capabilities on various receptors.
  • Synthetic Challenges: The synthesis of compounds like this can be complex, often involving multi-step reactions, which test a chemist's skills in organic synthesis.
  • Research Potential: The intricate structure may offer valuable insights into new drugs, as ongoing research continues to unveil the potential for novel therapeutic interventions.

Moreover, the presence of the two methoxy groups plays a crucial role in the electronic characteristics of the compound, impacting its reactivity and interactions with biological targets. As scientists delve deeper into the mechanisms of isoquinoline-related compounds, this specific molecule could provide significant data to further explore structure-activity relationships within medicinal chemistry.

As always, the journey of understanding such compounds is one filled with exciting challenges and revelations, revealing just how interconnected chemistry, biology, and medicine truly are!

Synonyms
Isoquinoline, 1,2,3,4-tetrahydro-2-(4-(p-chlorophenyl)butyl)-6,7-dimethoxy-1-methyl-, oxalate
2-(4-(p-Chlorophenyl)butyl)-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline oxalate
1900-33-0