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Nefazodone

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Identification
Molecular formula
C25H28ClN3O2
CAS number
83348-43-2
IUPAC name
2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl 3-(1-naphthyl)prop-2-enoate
State
State

At room temperature, nefazodone is in a solid state.

Melting point (Celsius)
143.00
Melting point (Kelvin)
416.15
Boiling point (Celsius)
736.60
Boiling point (Kelvin)
1 009.80
General information
Molecular weight
470.97g/mol
Molar mass
470.9530g/mol
Density
1.2150g/cm3
Appearence

Nefazodone is typically seen as a white to off-white crystalline powder.

Comment on solubility

Solubility of 2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl 3-(1-naphthyl)prop-2-enoate

The solubility of 2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl 3-(1-naphthyl)prop-2-enoate is indeed a fascinating subject, reflecting the complexities of organic compounds. Understanding its solubility can help in various applications, including pharmacology and material science. Here are some key points regarding its solubility:

  • Polar vs. Non-polar: This compound is characterized by both polar and non-polar components due to the presence of aromatic rings and piperazine. This often results in moderate solubility in organic solvents but limited solubility in water.
  • Interactions: The presence of the piperazine moiety can enhance solubility in polar solvents due to possible hydrogen bonding, while the chlorophenyl and naphthyl groups contribute to hydrophobic interactions.
  • Solvent Influence: Solubility can significantly vary depending on the solvent used. For example, this compound could show better solubility in solvents such as dichloromethane or ethanol, compared to more polar solvents like water.
  • Temperature Effect: As with many organic compounds, increasing the temperature can often improve solubility, making it crucial to consider this factor in practical applications.

In conclusion, the solubility of 2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl 3-(1-naphthyl)prop-2-enoate exhibits intriguing characteristics that are shaped by its molecular structure and the environment in which it is placed. Understanding these properties is essential for optimizing its usage in various fields.

Interesting facts

Interesting Facts about 2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl 3-(1-naphthyl)prop-2-enoate

The compound 2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl 3-(1-naphthyl)prop-2-enoate is a fascinating member of the chemical family known for its diverse applications in medicinal chemistry and research. Here are some intriguing aspects that highlight its significance:

  • Pharmacological Interest: This compound is potentially studied for its role as a pharmacological agent. Compounds containing piperazine rings are widely recognized in the development of pharmaceuticals, particularly for their activities on the central nervous system.
  • Chlorine Substituent: The presence of the 4-chlorophenyl group can significantly influence the compound's lipophilicity and biological activity, often enhancing the efficacy of interactions at target receptors.
  • Styrenic Structure: The styrenic moiety in the compound provides an avenue for further chemical modifications, allowing chemists to tailor the compound's properties for specific biological targets or to enhance its stability.
  • Research Applications: Due to its complex structure, this compound serves as a useful tool in research, particularly within the fields of neurobiology and pharmacology. It assists scientists in dissecting receptor interactions and pathways.
  • Analytical Techniques: Studying such a compound often requires advanced analytical techniques including NMR, HPLC, and mass spectrometry to elucidate its structure and confirm purity, showcasing the intricacies of modern chemistry research.

In summary, 2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl 3-(1-naphthyl)prop-2-enoate encapsulates a rich tapestry of chemical interaction potentials. Its structural attributes not only open doors to various therapeutic avenues but also pose exciting challenges in synthetic chemistry, paving the way for further exploration in the quest for new drugs and materials.