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Trazodone

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Identification
Molecular formula
C19H22ClN5O
CAS number
50-77-3
IUPAC name
2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl 3-(2-furyl)prop-2-enoate
State
State

Trazodone is primarily found in a solid state at room temperature and is used in the form of tablets for its applications in medicine.

Melting point (Celsius)
86.50
Melting point (Kelvin)
359.65
Boiling point (Celsius)
593.30
Boiling point (Kelvin)
866.45
General information
Molecular weight
408.86g/mol
Molar mass
408.3340g/mol
Density
1.3887g/cm3
Appearence

Trazodone typically appears as a white to off-white crystalline powder. It is known for being slightly soluble in water and more soluble in chloroform and methanol, which assists in pharmaceutical formulations.

Comment on solubility

Solubility of 2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl 3-(2-furyl)prop-2-enoate

The solubility of 2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl 3-(2-furyl)prop-2-enoate is an intriguing topic due to the compound's complex structure. Several factors influence its solubility, such as:

  • Polarity: The presence of the piperazine and furyl groups suggests varying degrees of polarity, which can affect how well the compound dissolves in different solvents.
  • Hydrophobic vs. Hydrophilic: While some parts of the molecule may interact well with water, other parts may prefer organic solvents, leading to differing solubility profiles.
  • pH Dependence: The ionization state of functional groups within the molecule under different pH conditions may also play a crucial role in its overall solubility.

It is essential to note that “solubility” is often a relative term, frequently expressed in terms of concentration limits in specific solvents. As a general observation, this compound may demonstrate:

  • Moderate solubility in organic solvents like DMSO or ethanol due to its complex aromatic and heterocyclic structure.
  • Poor solubility in water, which is common for many organic compounds with hydrophobic characteristics.

In conclusion, understanding the solubility profile of this chemical compound is crucial for its practical applications in pharmaceuticals and research. As with many drugs, detailed solubility studies can provide insights into the bioavailability and effectiveness of the compound in various environments.

Interesting facts

Interesting Facts about 2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl 3-(2-furyl)prop-2-enoate

This intriguing compound, often rooted in medicinal chemistry, is a fascinating example of how diverse structures can lead to significantly varied biological activities. Here are some captivating insights:

  • Structural Diversity: This compound exhibits a unique hybrid structure that combines a piperazine moiety with a furan group. The interplay of these distinct segments can influence its pharmacological profile.
  • Potential Biological Activity: Compounds similar to this one are often studied for their potential in treating various conditions, including mental health disorders and neurodegenerative diseases, due to their ability to interact with neurotransmitter systems.
  • Chirality Consideration: The presence of multiple stereocenters in the structure adds another layer of complexity, as different enantiomers (mirror-image forms) can exhibit varying degrees of biological activity, efficacy, and safety.
  • Scientific Research: Researchers have begun to explore the potential of such compounds in drug development, aiming for specificity and reduced side effects. The compound's structural characteristics may guide modifications that enhance its therapeutic potential.
  • Furan Ring Significance: The furan ring in this compound is particularly noteworthy, as it can participate in various chemical reactions, making it a valuable building block in organic synthesis and pharmaceutical design.

In conclusion, 2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl 3-(2-furyl)prop-2-enoate exemplifies the complexity and beauty of chemical compounds. Its unique structure and potential applications make it a subject of ongoing research and interest in the scientific community.