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GBR-12909

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Identification
Molecular formula
C20H26N2O4
CAS number
96349-59-8
IUPAC name
2-[4-(4-methoxyphenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone
State
State

At room temperature, GBR-12909 is typically found as a solid. This compound is used primarily for research purposes.

Melting point (Celsius)
130.00
Melting point (Kelvin)
403.00
Boiling point (Celsius)
569.50
Boiling point (Kelvin)
842.60
General information
Molecular weight
396.49g/mol
Molar mass
396.4870g/mol
Density
1.2141g/cm3
Appearence

GBR-12909 is often encountered as a crystalline compound. It can appear as a white to off-white solid in its pure form.

Comment on solubility

Solubility Overview

The compound 2-[4-(4-methoxyphenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone, known for its complex structural features, exhibits a distinct solubility profile influenced by several factors. Understanding its solubility is crucial in various applications, including pharmaceuticals and chemical synthesis.

Solubility Characteristics

  • Organic Solvents: This compound is generally soluble in non-polar to moderately polar organic solvents. Common solvents include:
    • Dimethyl sulfoxide (DMSO)
    • Ethanol
    • Acetone
  • Water Solubility: It shows limited solubility in water due to its hydrophobic characteristics, though this can vary based on pH and temperature.
  • Influence of Substituents: The presence of methoxy groups enhances solubility in organic media, while also impacting intermolecular interactions.

Important Notes

It is essential to consider factors such as temperature, pH, and solvent polarity when assessing its solubility. Moreover, as with many complex organic compounds, solubility can significantly affect bioavailability and reactivity in chemical processes.

As a rule of thumb, for compounds of this nature, it is advisable to conduct empirical testing to determine solubility under specific conditions. Always remember that solubility can vary widely among different formulations and environments.

Interesting facts

Interesting Facts About 2-[4-(4-methoxyphenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone

This compound, often referred to in research as an intriguing member of the class of piperazine derivatives, holds significant interest due to its potential pharmacological properties. Here are some remarkable aspects of this compound:

  • Pharmacological Activity: Studies suggest that piperazine derivatives can exhibit a variety of biological activities, including antidepressant, antipsychotic, and anti-anxiety effects. This compound shows potential as a candidate for further investigation in these areas.
  • Structural Complexity: The presence of multiple methoxy groups enhances the compound's lipophilicity, which can affect its ability to cross the blood-brain barrier. This structural feature is critical in drug design and development.
  • Research Significance: The synthesis and exploration of such compounds can contribute to the understanding of neurochemical pathways and the development of therapeutic agents targeted for mental health disorders.
  • Historical Context: Piperazine itself was first discovered in the 19th century and has since been foundational in medicinal chemistry, leading to numerous pharmaceutical formulations.
  • Potential Applications: Beyond mental health, compounds like these may also find roles in treating neurological disorders, thus providing a versatile platform for the synthesis of novel drugs.

In summary, the compound 2-[4-(4-methoxyphenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone not only showcases the complexity of synthetic organic chemistry but also sparks curiosity regarding its therapeutic potential and the pharmacological pathways it may influence. Each research endeavor contributes to the larger puzzle of understanding how such compounds can be utilized in real-world applications.

Synonyms
BRN 1607285
17755-64-5
ACETOPHENONE, 2-(4-(p-METHOXYPHENYL)PIPERAZINYL)-3',4',5'-TRIMETHOXY-
2-(4-(p-Methoxyphenyl)piperazinyl)-3',4',5'-trimethoxyacetophenone
1-(3,4,5-Trimethoxyphenacyl)-4-(p-methoxyphenyl)piperazine
DTXSID40170332
Piperazine, 1-(p-methoxyphenyl)-4-(3,4,5-trimethoxybenzoylmethyl)-
DTXCID0092823
5-23-02-00260 (Beilstein Handbook Reference)