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Fluoxetine

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Identification
Molecular formula
C17H18F3NO
CAS number
54910-89-3
IUPAC name
2-[4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl]-N-(2,6-dimethylphenyl)acetamide
State
State

Fluoxetine is typically found as a solid at room temperature.

Melting point (Celsius)
179.50
Melting point (Kelvin)
452.65
Boiling point (Celsius)
415.00
Boiling point (Kelvin)
688.15
General information
Molecular weight
309.41g/mol
Molar mass
309.4090g/mol
Density
1.2850g/cm3
Appearence

Fluoxetine is a white to off-white crystalline solid. It has a slightly bitter taste and is often administered in the form of hydrochloride salt, which enhances its solubility.

Comment on solubility

Solubility Insights for 2-[4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl]-N-(2,6-dimethylphenyl)acetamide

The compound 2-[4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl]-N-(2,6-dimethylphenyl)acetamide, with the chemical formula C17H18F3NO, exhibits intriguing solubility characteristics primarily influenced by its complex structure. Here's what stands out:

  • Polar vs. Nonpolar: The presence of both polar functional groups (such as the piperazine and acetamide moieties) and nonpolar aromatic rings suggests that this compound may exhibit moderate solubility in polar solvents like water, as well as in nonpolar solvents such as ethanol or chloroform.
  • Hydrogen Bonding: The ability to form hydrogen bonds due to the amide group contributes positively to its solubility in polar solvents, enhancing intermolecular interactions.
  • Fluorine Atoms: The incorporation of fluorine atoms can increase the lipophilicity, suggesting that the compound may have higher solubility in organic solvents compared to aqueous conditions.
  • Temperature Dependence: Like many organic compounds, the solubility of this compound may vary with temperature, generally increasing with rising temperatures due to increased kinetic energy.

Overall, while this compound may possess a moderate solubility in various solvents, the specific solubility behavior can be influenced by environmental factors and solvent choice. Understanding these properties is key in applications such as drug formulation and delivery. As a quote reminds us, "Solubility is often the gateway to bioavailability!"

Interesting facts

Interesting Facts About 2-[4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl]-N-(2,6-dimethylphenyl)acetamide

This compound is a fascinating example of a piperazine derivative, showcasing the versatility and complexity of organic chemistry. Here are some engaging insights:

  • Pharmacological Potential: Compounds like this one often exhibit significant biological activity, making them of great interest in medicinal chemistry. They can be investigated for their potential as novel therapeutic agents.
  • Targeting Affinity: The presence of a piperazine ring contributes to the compound's ability to interact with various receptors in the body, which is critical for drug design and efficacy.
  • Fluorine Influence: The incorporation of fluorophenyl groups can enhance metabolic stability and influence lipophilicity, potentially increasing the compound's bioavailability.
  • Synthetic Complexity: The synthesis of such a complex molecule requires advanced knowledge of organic reaction mechanisms, including multi-step synthesis techniques and careful handling of reagents.
  • Structure-Activity Relationship (SAR): Understanding the relationship between chemical structure and biological activity is essential. Modifications of this compound can provide insights into how changes in molecular composition affect its pharmacological properties.

In science, we delight in the intricacies of chemical compounds. As quoted by a renowned chemist, “The beauty of science is in its endless possibilities to discover and create.” With such compounds, we embark on a journey toward understanding and innovation in drug development and therapeutic strategies.

Overall, this compound represents the synergy of engineering, biology, and chemistry, paving the way for future advancements in medical science.

Synonyms
LIDOFLAZINE
3416-26-0
Ordiflazine
Corflazine
Clinium
Lidoflazin
Lidoflazinum
Angex
Klinium
Lidoflazina
Lidoflazina [Italian]
McN-JR 7904
Lidoflazinum [INN-Latin]
Lidoflazina [INN-Spanish]
R 7904
Lidoflazine [USAN:INN:BAN]
J4ZHN3HBTE
MCN-JR-7904
EINECS 222-312-8
BRN 0904339
Angex (TN)
DTXSID6045377
4-(4,4-Bis(p-fluorophenyl)butyl)-1-piperazineaceto-2',6'-xylidide
1-Piperazineacetamide, 4-(4,4-bis(4-fluorophenyl)butyl)-N-(2,6-dimethylphenyl)-
LIDOFLAZINE [MI]
LIDOFLAZINE [INN]
LIDOFLAZINE [USAN]
LIDOFLAZINE [MART.]
LIDOFLAZINE [WHO-DD]
CHEMBL92870
2-[4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl]-N-(2,6-dimethylphenyl)acetamide
McN-JR-7094
DTXCID4025377
R-7904
1-Piperazineaceto-2',6'-xylidide, 4-(4,4-bis(p-fluorophenyl)butyl)-
5-23-02-00297 (Beilstein Handbook Reference)
4-[4,4-Bis(4-fluorophenyl)butyl]-N-(2,6-dimethylphenyl)-1-piperazineacetamide
1-(4,4-Bis(4-fluorofenil)butil)-4-((2,6-dimetilanilinocarbonil)metil)piperazina [Italian]
NCGC00016627-01
NCGC00016627-04
CAS-3416-26-0
Lidoflazinum (INN-Latin)
Lidoflazina (INN-Spanish)
1-(4,4-Bis(4-fluorofenil)butil)-4-((2,6-dimetilanilinocarbonil)metil)piperazina
1-Piperazineacetamide, 4-[4,4-bis(4-fluorophenyl)butyl]-N-(2,6-dimethylphenyl)-
LIDOFLAZINE (MART.)
2-{4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl}-N-(2,6-dimethylphenyl)acetamide
UNII-J4ZHN3HBTE
Prestwick_700
MFCD00057353
Lidoflazine,98.5%
Prestwick0_000381
Prestwick1_000381
Prestwick2_000381
Prestwick3_000381
Lidoflazine (USAN/INN)
SCHEMBL79037
BSPBio_000561
MLS002153793
SPBio_002482
BPBio1_000619
BDBM23619
CHEBI:93095
C08EX01
HMS1569M03
HMS2096M03
HMS2232O16
HMS3372I14
HMS3713M03
Tox21_110533
AKOS040741955
Tox21_110533_1
CCG-220381
DB13766
Lidoflazine, >=98% (HPLC), powder
NCGC00016627-02
SMR001233173
HY-112075
CS-0043285
NS00010627
D04733
EN300-25890807
SR-01000841235
Q6543740
SR-01000841235-2
BRD-K62996583-001-03-8
BRD-K62996583-001-10-3
2-(4-[4,4-Bis(4-fluorophenyl)butyl]-1-piperazinyl)-N-(2,6-dimethylphenyl)acetamide #
2-[4-[4,4-bis(4-fluorophenyl)butyl]-1-piperazinyl]-N-(2,6-dimethylphenyl)acetamide
222-312-8