Skip to main content

Clopidogrel bisulfate

ADVERTISEMENT
Identification
Molecular formula
C16H16ClNO2S • H2SO4
CAS number
120202-66-6
IUPAC name
2-[4-(5-chloro-1,3-benzothiazol-2-yl)phenoxy]-N,N-diethyl-ethanamine;(2R,3R)-2,3-dihydroxybutanedioic acid
State
State

At room temperature, Clopidogrel bisulfate exists as a solid. It is often administered in tablet form as an oral medication.

Melting point (Celsius)
184.50
Melting point (Kelvin)
457.65
Boiling point (Celsius)
510.10
Boiling point (Kelvin)
783.25
General information
Molecular weight
419.90g/mol
Molar mass
419.9020g/mol
Density
1.4476g/cm3
Appearence

Clopidogrel bisulfate is generally found as an off-white to light brown powder. It is hygroscopic and sensitive to both light and heat. Typically, it is presented in the form of tablets for pharmaceutical use.

Comment on solubility

Solubility of 2-[4-(5-chloro-1,3-benzothiazol-2-yl)phenoxy]-N,N-diethyl-ethanamine; (2R,3R)-2,3-dihydroxybutanedioic acid

The solubility of the compound C16H16ClNO2S • H2SO4 is influenced by a variety of factors, including its structural characteristics and the presence of functional groups. Here are some key points regarding its solubility:

  • Polarity: The presence of polar functional groups such as the sulfonic acid in H2SO4 suggests that the compound may exhibit higher solubility in aqueous environments.
  • Hydrophobic Phenyl Ring: The benzothiazole and aromatic components contribute hydrophobic characteristics, which can limit solubility in water but enhance solubility in organic solvents.
  • Temperature and pH Effects: Solubility can significantly alter with changes in temperature or pH, particularly due to the acidic nature of the compound.
  • Solvent Selectivity: The compound is expected to have varying solubility in different solvents:
    • Water: Limited solubility due to hydrophobic regions.
    • Organic Solvents: Enhanced solubility in polar aprotic solvents.

In summary, the solubility of this compound can be described as a balance between its hydrophilic and hydrophobic elements, creating a complex interaction with solvents that can be tailored through environmental adjustments. As with many such compounds, understanding the specific conditions under which it dissolves is crucial for its practical application.

Interesting facts

Interesting Facts about 2-[4-(5-chloro-1,3-benzothiazol-2-yl)phenoxy]-N,N-diethyl-ethanamine; (2R,3R)-2,3-dihydroxybutanedioic acid

This compound, a fascinating combination of a phenolic ether and a dihydroxy acid, boasts a range of interesting characteristics that highlight its significance in both medicinal chemistry and material science.

Key Highlights:

  • Pharmacological Potential: The benzothiazole moiety is known for its diverse biological activities, making this compound of interest in the development of new pharmaceuticals.
  • Mechanism of Action: The compound's potential mechanism may involve pathways related to the modulation of neurotransmitter systems, which could be beneficial in treating neurological disorders.
  • Synthetic Versatility: Its structure allows for modifications that can enhance its activity or alter its pharmacokinetic properties, providing a platform for drug design and discovery.
  • Stability and Reactivity: The presence of both a strong aromatic system and functional groups enhances its stability while also offering potential sites for chemical reactivity in further synthetic applications.
  • Environmental Considerations: The inclusion of sulfuric acid in the structure underlines its role in certain synthesis processes, drawing attention to the importance of understanding the environmental impact of such reagents.

Furthermore, this compound exemplifies the intriguing intersection of organic synthesis and pharmaceutical application, as it combines elements that are vital for designing effective therapeutic agents. As researchers continue to explore its properties, we can expect its role in drug development to evolve, potentially unlocking new avenues for treatment approaches.

In summary, the compound is not only a subject of academic interest but also holds potential practical applications that could significantly contribute to advancements in therapeutic technologies.

Synonyms
haletazole tartrate
Episol tartrate
10390-80-4
K9P885JEKK
UNII-K9P885JEKK
5-Chloro-2-(4-(2-(diethylamino)ethoxy)phenyl)benzothiazole tartrate
BENZOTHIAZOLE, 5-CHLORO-2-(p-(2-(DIETHYLAMINO)ETHOXY)PHENYL)-, TARTRATE
BENZOTHIAZOLE, 5-CHLORO-2-(P-(2-(DIETHYLAMINO)ETHOXY)PHENYL)-, TARTRATE (1:1)
2-[4-(5-chloro-1,3-benzothiazol-2-yl)phenoxy]-N,N-diethylethanamine;(2R,3R)-2,3-dihydroxybutanedioic acid
DTXSID90908662
Q27282135
2,3-Dihydroxybutanedioic acid--2-[4-(5-chloro-1,3-benzothiazol-2-yl)phenoxy]-N,N-diethylethan-1-amine (1/1)