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Chloroquine

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Identification
Molecular formula
C18H26ClN3
CAS number
54-05-7
IUPAC name
2-[4-[(7-chloro-4-quinolyl)amino]pentyl-ethyl-amino]ethanol
State
State

At room temperature, chloroquine is in a crystalline solid state. It is non-volatile and typically handled in its salt form, which is soluble in water.

Melting point (Celsius)
87.00
Melting point (Kelvin)
360.00
Boiling point (Celsius)
280.00
Boiling point (Kelvin)
553.00
General information
Molecular weight
319.87g/mol
Molar mass
319.8720g/mol
Density
1.3000g/cm3
Appearence

Chloroquine is a white to slightly yellow crystalline powder. It is odorless and has a bitter taste. The compound is usually supplied in its diphosphate or hydrochloride salt form for medicinal use.

Comment on solubility

Solubility of 2-[4-[(7-chloro-4-quinolyl)amino]pentyl-ethyl-amino]ethanol (C18H26ClN3)

The solubility of this compound is quite noteworthy due to its complex structure, which can significantly influence its behavior in various solvents. Here are some key considerations regarding its solubility:

  • Polar vs Non-polar Solvents: Given the presence of both hydrophilic amine groups and a hydrophobic quinoline ring, the compound is expected to demonstrate variable solubility in solvents depending on their polarity. Generally, it may exhibit higher solubility in polar solvents such as water or ethanol.
  • Temperature Dependence: Solubility can also increase with temperature. As solubility is often temperature-dependent, heating the solvent could enhance the dissolving capability for this compound.
  • Concentration Effects: At higher concentrations, the solubility may approach a saturation point. Thus, understanding the solubility limit is crucial for practical applications.
  • pH Sensitivity: The solubility may vary with changes in pH, particularly because the compound contains amine functionalities that might protonate in acidic conditions, influencing its hydrophilicity.

Overall, the solubility profile of C18H26ClN3 is influenced by several factors. It is essential to consider these factors in real-world applications and formulation strategies to optimize functionality.

Interesting facts

Interesting Facts About 2-[4-[(7-chloro-4-quinolyl)amino]pentyl-ethyl-amino]ethanol

This fascinating compound, known for its unique structure, belongs to a class of chemical entities that exhibit potential biological activity. Here are some engaging insights into its characteristics:

  • Pharmaceutical Potential: This compound exhibits properties that may make it valuable in medicinal chemistry, particularly in the realm of drug development. Its association with quinoline derivatives often leads to promising pharmacological effects.
  • Structure and Functional Groups: With a complex structure featuring a chloroquinoline moiety and an amino alcohol component, the compound exhibits characteristics typical of pharmacologically active substances, allowing for multiple interaction sites with biological targets.
  • Quinoline Connection: Quinoline derivatives, like the one found in this compound, are known for their diverse biological activities, including antimicrobial, anti-inflammatory, and antitumor properties, making them an area of interest for ongoing research.
  • Synthetic Pathways: The synthesis of this compound involves various organic reactions, which may include amination and alkylation processes. The complexity of its synthesis allows chemists to explore innovative strategies for variations and analog development.
  • Research Applications: Scientific investigations utilizing this compound often delve into its mechanism of action in biological systems. Researchers may study its interaction with specific enzymes or receptors, supplying valuable insights into cellular processes.

In summary, 2-[4-[(7-chloro-4-quinolyl)amino]pentyl-ethyl-amino]ethanol stands out not only for its intriguing structure but also for its significance in the fields of chemistry and pharmacology. As scientists continue to explore its properties and applications, it holds promise for future therapeutic advancements.

Synonyms
hydroxychloroquine
118-42-3
Plaquenil
Oxichloroquine
Oxychlorochin
Oxychloroquine
Oxichlorochinum
Hidroxicloroquina
Polirreumin
Hydroxychloroquinum
oxichlorochine
Idrossiclorochina
WIN 1258
2-((4-((7-Chloroquinolin-4-yl)amino)pentyl)(ethyl)amino)ethanol
Hidroxicloroquina [INN-Spanish]
Hydroxychloroquinum [INN-Latin]
2-((4-((7-Chloro-4-quinolyl)amino)pentyl)ethylamino)ethanol
CHEBI:5801
Dolquine
7-Chloro-4-(4-(ethyl(2-hydroxyethyl)amino)-1-methylbutylamino)quinoline
UNII-4QWG6N8QKH
4QWG6N8QKH
2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethanol
EINECS 204-249-8
2-(N-(4-(7-Chlor-4-chinolylamino)-4-methylbutyl)ethylamino)ethanol
7-Chloro-4-(4-(N-ethyl-N-beta-hydroxyethylamino)-1-methylbutylamino)quinoline
BRN 0253894
7-Chloro-4-(5-(N-ethyl-N-2-hydroxyethylamino)-2-pentyl)aminoquinoline
(+-)-hydroxychloroquine
Hydroxychloroquine (INN)
MFCD00242707
HCQ
2-[{4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino]ethanol
Ethanol, 2-((4-((7-chloro-4-quinolinyl)amino)pentyl)ethylamino)-
DTXSID8023135
Z0188
2-[[4-[(7-chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol
Hydroxychlorochin
2-({4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino)ethan-1-ol
Ethanol, 2-[[4-[(7-chloro-4-quinolinyl)amino]pentyl]ethylamino]-
5-22-10-00280 (Beilstein Handbook Reference)
Idrossiclorochina [DCIT]
NSC4375
Ethanol, 2-((4-((7-chloro-4-quinolyl)amino)pentyl)ethylamino)-
HYDROXYCHLOROQUINE [INN]
Hidroxicloroquina (INN-Spanish)
Hydroxychloroquinum (INN-Latin)
Hydroxychloroquine [INN:BAN]
2-{N-[4-(7-Chloro-4-quinolylamino)pentyl]-N-ethylamino}ethanol
(+/-)-2-((4-((7-CHLORO-4-QUINOLYL)AMINO)PENTYL)ETHYLAMINO)ETHANOL
7-chloro-4-[4-(N-ethyl-N-beta-hydroxyethylamino)-1-methylbutylamino]quinoline
7-chloro-4-[5-(N-ethyl-N-2-hydroxyethylamino)-2-pentyl]aminoquinoline
ETHANOL, 2-((4-((7-CHLORO-4-QUINOLINYL)AMINO)PENTYL)ETHYL)AMINO-, (+/-)-
Polirreumin (TN)
NCGC00159483-02
idroxiclorochina
Ethanol, 2-[[4-[(7-chloro-4-quinolyl)amino]pentyl]ethylamino]-
2-((4-((7-Chloroquinolin-4-yl)amino)pentyl)(ethyl)amino)ethan-1-ol
R-Hydroxychloroquine?
Ercoquin (Salt/Mix)
Spectrum2_001238
Spectrum5_001697
(+/-)-hydroxychloroquine
SCHEMBL8170
CHEMBL1535
(.+/-.)-Hydroxychloroquine
DivK1c_000942
SPBio_001116
HYDROXYCHLOROQUINE [MI]
DTXCID403135
GTPL7198
HMS502P04
KBio1_000942
HYDROXYCHLOROQUINE [VANDF]
P01BA02
Win 1258-2
HYDROXY CHLOROQUINE SULFATE
NINDS_000942
2-[4-[(7-chloro-4-quinolyl)amino]pentyl-ethyl-amino]ethanol
HYDROXYCHLOROQUINE [WHO-DD]
2-[[4-[(7-Chloro-4-quinolyl)amino]pentyl](ethyl)amino]ethanol
BCP30197
IGA74976
2-({4-[(7-chloro(4-quinolyl))amino]pentyl}ethylamino)ethan-1-ol
BDBM50467780
STL429829
AKOS015997886
AT13123
CCG-208059
DB01611
DT-0016
HY-W031727
SB73036
IDI1_000942
NCGC00159483-03
NCGC00159483-06
DA-74343
SY270913
SBI-0052759.P002
CS-0075751
NS00001228
C07043
D08050
EN300-122642
AB00053257_02
Q421094
BRD-A99117172-065-01-6
BRD-A99117172-065-02-4
BRD-A99117172-065-04-0
BRD-A99117172-065-05-7
F2173-0553
2-((4-(7-chloroquinolin-4-ylamino)pentyl)(ethyl)amino)ethanol
2-[(4-[(7-Chloro-4-quinolinyl)amino]pentyl)(ethyl)amino]ethanol #
7-chloro-4-[4-[ethyl(2-hydroxyethyl)amino]1-methylbutylamino]-quinoline
7-chloro-4-[4-[ethyl(2-hydroxyethyl)amino]1-methylbutylamino]quinoline
7-Chloro-4-[4-[ethyl-(2-hydroxyethyl)amino]-1-methylbutylamino]quinoline
7-Chloro-4-(4-(N-ethyl-N-.beta.-hydroxyethylamino)-1-methylbutylamino)quinoline
204-249-8
Oxichloroquine;Oxychlorochin;2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol