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Chloroquine phosphate

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Identification
Molecular formula
C18H26ClN3O·H3PO4
CAS number
50-63-5
IUPAC name
2-[4-[(7-chloro-4-quinolyl)amino]pentyl-ethyl-amino]ethanol;sulfuric acid
State
State

Chloroquine phosphate is typically in a solid state as a crystalline powder at room temperature.

Melting point (Celsius)
87.50
Melting point (Kelvin)
360.65
Boiling point (Celsius)
405.10
Boiling point (Kelvin)
678.25
General information
Molecular weight
515.86g/mol
Molar mass
515.8610g/mol
Density
1.1000g/cm3
Appearence

Chloroquine phosphate typically appears as a white to slightly yellow, crystalline powder. It is odorless and has a bitter taste.

Comment on solubility

Solubility of 2-[4-[(7-chloro-4-quinolyl)amino]pentyl-ethyl-amino]ethanol; sulfuric acid

The solubility of the compound 2-[4-[(7-chloro-4-quinolyl)amino]pentyl-ethyl-amino]ethanol; sulfuric acid can present some intriguing characteristics due to its chemical structure. Understanding solubility is crucial, as it influences the compound's behavior in various applications.

Factors Affecting Solubility

  • Polarity: The presence of multiple functional groups, including the amino and hydroxyl groups, often leads to higher polarity, potentially enhancing solubility in polar solvents.
  • pH Levels: As a compound involving sulfuric acid, the solubility may increase in acidic conditions due to protonation of the amino groups, which typically enhances solubility in water.
  • Temperature: Higher temperatures generally increase solubility for many compounds; however, this can vary based on specific interactions within the compound.
  • Hydrogen Bonding: The ability to form hydrogen bonds can significantly enhance solubility in aqueous environments.

In summary, the solubility of 2-[4-[(7-chloro-4-quinolyl)amino]pentyl-ethyl-amino]ethanol; sulfuric acid is expected to be influenced by its polar functional groups, the acidic conditions provided by sulfuric acid, and the potential for extensive hydrogen bonding. These factors should be carefully considered in practical applications involving this compound.

Interesting facts

Interesting Facts about 2-[4-[(7-Chloro-4-quinolyl)amino]pentyl-ethyl-amino]ethanol; Sulfuric Acid

The compound known as 2-[4-[(7-chloro-4-quinolyl)amino]pentyl-ethyl-amino]ethanol combined with sulfuric acid represents a fascinating area of study in medicinal chemistry.

Medicinal Applications

This compound is particularly noteworthy due to its potential as a therapeutic agent. It exhibits properties that may be beneficial in the treatment of various diseases. Some intriguing aspects are:

  • Antimicrobial Activity: Compounds with a quinoline structure are often recognized for their capability to combat bacterial infections.
  • Drug Development: The combination of quinoline and aminoethanol moieties opens doors for the design of novel pharmaceuticals.
  • Potential Antiparasitic Effects: Research has shown that certain derivatives of quinoline can target specific pathways in parasites.

Mechanisms of Action

The active components within this compound may interact with biological systems through:

  • Inhibition of Enzymes: Similar compounds have been observed to inhibit essential enzymes in microbial cells.
  • Disruption of Cell Membrane Integrity: The molecular structure allows for interaction with lipid membranes, causing potential integrity issues.

Research and Development

Current research focuses on:

  • Synthetic Pathways: Investigating efficient synthesis routes to enhance yield and reduce costs.
  • Toxicity Studies: Ensuring safety and efficacy in potential clinical applications.
  • Structure-Activity Relationship (SAR): Understanding how changes in molecular structure affect biological activity.

In summary, 2-[4-[(7-chloro-4-quinolyl)amino]pentyl-ethyl-amino]ethanol with sulfuric acid showcases how intricate molecular design can pave the way for developing essential therapeutic agents. As research progresses, it is likely that further discoveries will reveal more about the utility and safety of this compound.

Synonyms
HYDROXYCHLOROQUINE SULFATE
747-36-4
Ercoquin
Plaquinol
Toremonil
Quensyl
Oxiklorin
Plaquenil sulfate
NSC 4375
NSC-4375
EINECS 212-019-3
UNII-8Q2869CNVH
8Q2869CNVH
DTXSID1047811
AI3-52706
Hydroxychloroquine sulfate [USP]
DTXCID9027788
2-((4-((7-Chloro-4-quinolinyl)amino)pentyl)ethylamino)ethanol sulfate (1:1) (salt)
Ethanol, 2-((4-((7-chloro-4-quinolyl)amino)pentyl)ethylamino)-, sulfate (1:1) (salt)
NSC4375
Ethanol, 2-((4-((7-chloro-4-quinolinyl)amino)pentyl)ethylamino)-, sulfate (1:1)
Hydroxychloroquine sulfate (USP)
HYDROXYCHLOROQUINE SULFATE (MART.)
HYDROXYCHLOROQUINE SULFATE [MART.]
HYDROXYCHLOROQUINE SULFATE (USP-RS)
HYDROXYCHLOROQUINE SULFATE [USP-RS]
HYDROXYCHLOROQUINE SULFATE (EP MONOGRAPH)
HYDROXYCHLOROQUINE SULFATE [EP MONOGRAPH]
Hydroxychloroquinesulfate
HYDROXYCHLOROQUINE SULFATE (USP MONOGRAPH)
HYDROXYCHLOROQUINE SULFATE [USP MONOGRAPH]
Ethanol, 2-[[4-[(7-chloro-4-quinolinyl)amino]pentyl]ethylamino]-, sulfate (1:1)
Hydroxychloroquine Sulfate (1:1) Salt
(+-)-2-((4-((7-Chloro-4-quinolyl)amino)pentyl)ethylamino)ethanol sulfate (1:1) (salt)
HYDROXYCHLOROQUINE SULFATEfilm coated
Ethanol, 2-((4-((7-chloro-4-quinolinyl)amino)pentyl)ethyl)amino-, (+-)-, sulfate (1:1) salt
212-019-3
(+-)-2-((4-((7-chloro-4-quinolyl)amino)pentyl)ethylamino)ethanol sulphate (1:1) (salt)
2-(((4rs)-4-((7-chloroquinolin-4-yl)amino)pentyl)(ethyl)amino)ethanol monosulfate
ethanol, 2-((4-((7-chloro-4-quinolinyl)amino)pentyl)ethyl)amino-, (+-)-, sulphate (1:1) salt
Hydroxychloroquine sulphate
Plaquenil
2-((4-((7-Chloroquinolin-4-yl)amino)pentyl)(ethyl)amino)ethanol sulfate
TCMDC-123987
Hydroxychloroquine (sulfate)
Oxichlorochine Sulfate
2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethanol;sulfuric acid
2-({4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino)ethan-1-ol; sulfuric acid
Hydroxychloroquine (sulfate) (Standard)
C18H28ClN3O5S
(+/-)-2-((4-((7-CHLORO-4-QUINOLYL)AMINO)PENTYL)ETHYLAMINO)ETHANOL SULFATE (1:1) (SALT)
(+/-)-2-((4-((7-CHLORO-4-QUINOLYL)AMINO)PENTYL)ETHYLAMINO)ETHANOL SULPHATE (1:1) (SALT)
CAS-747-36-4
ETHANOL, 2-((4-((7-CHLORO-4-QUINOLINYL)AMINO)PENTYL)ETHYL)AMINO-, (+/-)-, SULFATE (1:1) SALT
ETHANOL, 2-((4-((7-CHLORO-4-QUINOLINYL)AMINO)PENTYL)ETHYL)AMINO-, (+/-)-, SULPHATE (1:1) SALT
SR-05000001881
NCGC00159483-02
MFCD00078203
Quinoric
2-[[4-[(7-Chloro-4-quinolinyl)amino]pentyl]ethylamino]ethanol
HCQ sulfate
Plaquenil (TN)
Ethanol, monosulfate
Hydroxychlorquine sulfate
2-[[4-[(7-Chloro-4-quinolinyl)amino]pentyl]ethylamino]ethanol sulfate
2-((4-((7-Chloro-4-quinolyl)amino)pentyl)ethylamino)ethanol sulfate (1:1) (salt)
CHEMBL1690
SCHEMBL41114
SPECTRUM1503978
747-36-4 (sulfate)
HY-B1370R
JCBIVZZPXRZKTI-UHFFFAOYSA-N
Ethanol, sulfate (1:1) (salt)
GLXC-06904
HMS1922O12
HMS2093O05
HMS3713J22
Pharmakon1600-01503978
BCP12823
HY-B1370
Tox21_111707
BDBM50247975
CCG-39154
NSC758663
s4430
Hydroxychloroquine sulfate (JAN/USP)
2-((4-((7-Chloroquinolin-4-yl)amino)-pentyl)(ethyl)amino)ethanol sulfate
2-((4-((7-chloroquinolin-4-yl)amino)pentyl)(ethyl)amino)ethan-1-ol sulfate
AKOS015897337
Tox21_111707_1
CS-8017
FH24322
HYDROXYCHLOROQUINE SULFATE [MI]
KS-5311
NSC-758663
SB19140
7-Chloro-4-[4-[N-ethyl-N-(2-hydroxyethyl)amino]-1-methylbutylamino]quinoline Sulfate
HYDROXYCHLOROQUINE SULFATE [JAN]
N4-(7-Chloro-4-quinolyl)-N1-ethyl-N1-(2-hydroxyethyl)-1,4-pentanediamine Sulfate
NCGC00095090-01
NCGC00095090-02
NCGC00159483-04
BH164525
HYDROXYCHLOROQUINE SULFATE [VANDF]
HYDROXYCHLOROQUINE SULFATE [WHO-DD]
DB-055904
CS-0694855
H1306
NS00076196
Hydroxychloroquine sulfate - Bio-X trade mark
Hydroxycloroquine sulfate, analytical standard
D02114
EN300-122765
H10433
HYDROXYCHLOROQUINE SULFATE [ORANGE BOOK]
Hydroxychloroquine sulfate, >=98% (HPLC), powder
SR-05000001881-1
SR-05000001881-2
Q27270879
Hydroxychloroquine Sulphate 1.0 mg/ml in Methanol (as free base)
2-((4-(7-chloroquinolin-4-ylamino)pentyl)(ethyl)amino)ethanol sulfate
2-(((4RS)-4-((7-Chloroquinolin-4-yl)amino)pentyl)(ethyl)amino)ethanol monosulfate
Hydroxychloroquine Sulfate, Pharmaceutical Secondary Standard; Certified Reference Material
Hydroxychloroquine sulfate, United States Pharmacopeia (USP) Reference Standard
14480-75-2