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N-(4-Acetamidophenyl)-2-(2-iodoacetoxy)ethylsulfonamide

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Identification
Molecular formula
C12H15I1N2O5S1
CAS number
879488-81-8
IUPAC name
2-[(4-acetamidophenyl)sulfonylamino]ethyl 2-iodoacetate
State
State

The compound is a crystalline solid at room temperature. It is typically stored and handled as a dry solid in a controlled environment to prevent degradation or reaction with moisture.

Melting point (Celsius)
104.00
Melting point (Kelvin)
377.15
Boiling point (Celsius)
280.00
Boiling point (Kelvin)
553.15
General information
Molecular weight
392.30g/mol
Molar mass
392.2960g/mol
Density
1.7320g/cm3
Appearence

This compound typically appears as a solid with a crystalline texture. The color can range from white to off-white, depending on purity and specific conditions. It is often used in organic synthesis applications as a reagent.

Comment on solubility

Solubility of 2-[(4-acetamidophenyl)sulfonylamino]ethyl 2-iodoacetate

The solubility of 2-[(4-acetamidophenyl)sulfonylamino]ethyl 2-iodoacetate, with its complex structure, can be influenced by several factors, which makes the understanding of its solubility an intriguing topic. Here are key points to consider:

  • Polarity: The presence of both sulfonamide and acetate functional groups suggests a degree of polarity, which can enhance solubility in polar solvents.
  • Hydrogen Bonding: The acetamido group can interact with water through hydrogen bonding, potentially improving its solubility in aqueous solutions.
  • Solvent Compatibility: This compound may exhibit different solubility profiles in various solvents such as:
    • Aqueous solutions - Likely moderate solubility due to polar interactions.
    • Organic solvents - Solubility might vary depending on the solvent’s polarity.
  • Temperature Influence: As with many chemical compounds, increasing temperature may enhance solubility, allowing greater interaction between the solute and solvent molecules.

In summary, while the exact solubility of 2-[(4-acetamidophenyl)sulfonylamino]ethyl 2-iodoacetate can vary, factors such as polarity, hydrogen bonding, solvent selection, and temperature play important roles. Understanding these factors can guide researchers in predicting the behavior of this compound in various chemical environments.

Interesting facts

Interesting Facts about 2-[(4-acetamidophenyl)sulfonylamino]ethyl 2-iodoacetate

This compound, with its complex structure, presents a fascinating intersection of organic chemistry and medicinal applications. Here are some interesting insights:

  • Functional Groups: The presence of both an acetamide and a sulfonamide moiety indicates potential biological activity, as these groups are known to interact favorably with various biological systems.
  • Structural Diversity: The molecule includes a unique combination of an aliphatic ester and a sulfonylamino group, which enhances its potential versatility in chemical reactions and biological interactions.
  • Applications in Drug Design: Compounds structurally similar to this one are often investigated for their use in pharmaceuticals, particularly for targeting specific biological pathways associated with diseases.
  • Reactivity: The iodoacetate functional group is known for its capacity to undergo nucleophilic substitutions, making it a valuable derivative in synthetic organic chemistry.
  • Research Interest: Due to its unique structure, this compound is likely to be a subject of interest in the fields of organic synthesis, medicinal chemistry, and drug discovery.

In summary, the intriguing characteristics of 2-[(4-acetamidophenyl)sulfonylamino]ethyl 2-iodoacetate not only shed light on its potential utility in academic research but also emphasize the importance of complex molecular architectures in developing innovative therapeutic agents.

Synonyms
2-(N4-Acetylsulfanilamido)ethyl iodoacetate
UNII-NL03FNT54F
NL03FNT54F
BRN 2899154
ACETIC ACID, IODO-, ESTER with 4'-((2-HYDROXYETHYL)SULFAMOYL)ACETANILIDE
2-(N(sup 4)-Acetylsulfanilamido)ethyl iodoacetate
Iodoacetic acid ester with 4'-((2-hydroxyethyl)sulfamoyl)acetanilide
DTXSID20174010
ACETANILIDE, 4'-((2-HYDROXYETHYL)SULFAMOYL)-, IODOACETATE (ESTER)
ACETIC ACID, 2-IODO-, 2-(((4-(ACETYLAMINO)PHENYL)SULFONYL)AMINO)ETHYL ESTER
ACETIC ACID, IODO-, 2-(((4-(ACETYLAMINO)PHENYL)SULFONYL)AMINO)ETHYL ESTER
DTXCID1096501
2018-25-9
Q27284925