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Lidocaine hydrochloride

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Identification
Molecular formula
C14H22ClN2O2
CAS number
73-78-9
IUPAC name
2-[(4-acetamidophenyl)sulfonylamino]ethyl-diethyl-ammonium;chloride
State
State
At room temperature, lidocaine hydrochloride is typically found in a solid state as a white crystalline powder. In medical settings, it is frequently encountered as a clear, aqueous solution for injection.
Melting point (Celsius)
80.00
Melting point (Kelvin)
353.15
Boiling point (Celsius)
180.00
Boiling point (Kelvin)
453.15
General information
Molecular weight
288.81g/mol
Molar mass
288.8140g/mol
Density
1.1980g/cm3
Appearence

Lidocaine hydrochloride appears as a white, crystalline powder that is odorless. It is often marketed as an aqueous solution for injection, appearing as a clear, sterile, isotonic solution. The compound can also be found in forms suitable for topical application.

Comment on solubility

Solubility of 2-[(4-acetamidophenyl)sulfonylamino]ethyl-diethyl-ammonium;chloride

The solubility of 2-[(4-acetamidophenyl)sulfonylamino]ethyl-diethyl-ammonium;chloride can be influenced by several factors, making it essential to consider the following aspects:

  • Solvent Polarity: This compound is likely to exhibit good solubility in polar solvents such as water. The presence of the ammonium group and sulfonyl moiety enhances its interaction with polar solvent molecules.
  • Temperature: As with many ionic compounds, an increase in temperature generally increases solubility. Thus, dissolving this compound in warm water may be more effective.
  • pH Level: Being a quaternary ammonium salt, its solubility may be affected by the pH of the solution. An increase in pH could lead to increased solubility due to deprotonation effects.
  • Ionic Strength: The presence of other ions in the solution can either enhance or hinder solubility through various interactions, including salting out or salting in effects.

In general, compounds of similar structures are characterized by their capacity to dissolve in aqueous solutions, particularly due to ionic interactions. Studies have shown that quaternary ammonium salts typically display high solubility in water. As a result, it can be anticipated that 2-[(4-acetamidophenyl)sulfonylamino]ethyl-diethyl-ammonium;chloride will follow this trend, making it suitable for applications that necessitate a aqueous environment.

Interesting facts

Interesting Facts about 2-[(4-acetamidophenyl)sulfonylamino]ethyl-diethyl-ammonium Chloride

The compound 2-[(4-acetamidophenyl)sulfonylamino]ethyl-diethyl-ammonium chloride, commonly referred to as a quaternary ammonium compound, is noteworthy for several compelling reasons:

  • Quaternary Ammonium Compounds: These compounds are recognized for their antimicrobial properties, making them useful in various disinfectants and surface cleaners.
  • Drug Discovery: This particular compound has garnered interest in pharmaceutical research, particularly in the development of new therapeutics and drug formulations.
  • Structural Significance: The presence of a sulfonamide group is significant as it is known for enhancing the biological activity of drugs while also improving their solubility.
  • Stability: Quaternary ammonium compounds are generally stable, which aids in their effectiveness and longevity in applications.

The design and synthesis of such compounds can often result in robust variations that exhibit unique properties. As one researcher noted, "The fine-tuning of the ammonium moiety can lead to remarkable enhancements in stability and selectivity in biological environments." This work contributes to ongoing research in medicinal chemistry and material science.

Moreover, the integration of an acetamido group in its structure suggests potential for further modification, paving the way for innovative derivatives that could hold promise in targeted therapies.

Overall, 2-[(4-acetamidophenyl)sulfonylamino]ethyl-diethyl-ammonium chloride is not only a notable compound in chemical research but also serves as a bridge between basic research and practical applications in health and hygiene.

Synonyms
5081 HC
4'-((2-(Diethylamino)ethyl)sulfamoyl)acetanilide hydrochloride
HC 5081
ACETANILIDE, 4'-((2-(DIETHYLAMINO)ETHYL)SULFAMOYL)-, HYDROCHLORIDE
N(sup 1)-(Diethylamino-2 ethyl) p-acetamido benzenesulfonamide chlorhydrate [French]
1910-29-8
N(sup 1)-(Diethylamino-2 ethyl) p-acetamido benzenesulfonamide chlorhydrate