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Nimesulide

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Identification
Molecular formula
C13H12N2O5S
CAS number
51803-78-2
IUPAC name
2-[[4-(acetylsulfamoyl)phenyl]carbamoyl]benzoic acid
State
State

At room temperature, Nimesulide is a solid. It is a stable compound under standard temperature and pressure, maintaining its solid-state form as a fine crystalline powder.

Melting point (Celsius)
140.00
Melting point (Kelvin)
413.15
Boiling point (Celsius)
297.10
Boiling point (Kelvin)
570.25
General information
Molecular weight
308.32g/mol
Molar mass
308.3150g/mol
Density
1.3400g/cm3
Appearence

Nimesulide appears as a yellow, crystalline powder. It is known for its characteristic warm yellow hue, which can appear pale under certain lighting conditions. The substance is crystalline in nature, presenting as fine particles.

Comment on solubility

Solubility of 2-[[4-(acetylsulfamoyl)phenyl]carbamoyl]benzoic acid

The solubility of 2-[[4-(acetylsulfamoyl)phenyl]carbamoyl]benzoic acid can be influenced by various factors due to its complex structure. Here are some key points to consider:

  • Solvent Type: This compound's solubility may vary significantly in different solvents. Typically, it may be more soluble in polar solvents such as water or dimethyl sulfoxide (DMSO) due to the presence of polar functional groups.
  • Temperature Influence: Like many organic compounds, an increase in temperature may lead to an enhanced solubility. As temperature rises, the solubility of solid compounds generally increases.
  • pH Levels: Given its acidic nature, adjusting the pH of the solvent may alter the solubility of the compound. An acidic environment can improve solubility in some cases.
  • Concentration: The concentration of the compound in the solvent can also play a critical role. At higher concentrations, precipitation may occur, leading to a decrease in observed solubility.

In summary, the solubility of 2-[[4-(acetylsulfamoyl)phenyl]carbamoyl]benzoic acid is dependent on a variety of factors, and understanding those can enhance our ability to predict and manipulate its behavior in solution.

Interesting facts

Interesting Facts about 2-[[4-(Acetylsulfamoyl)phenyl]carbamoyl]benzoic Acid

2-[[4-(Acetylsulfamoyl)phenyl]carbamoyl]benzoic acid, often abbreviated in the scientific community, is a compound that showcases a unique blend of chemical properties and potential applications. Here are some intriguing points to consider:

  • Pharmaceutical Applications: This compound is being studied for its potential role as an active pharmaceutical ingredient (API). Its structure suggests it may exhibit anti-inflammatory and analgesic properties, making it a candidate for pain relief medications.
  • Mechanism of Action: The acetylsulfamoyl group in the compound may offer unique interactions with biological targets, potentially modifying enzyme activity involved in pain signaling pathways.
  • Synthesis and Chemistry: The synthetic pathway for creating this compound is fascinating. It typically involves multiple steps, including the formation of amides and the introduction of the sulfonamide functional group, demonstrating core organic chemistry principles in action.
  • Research Interest: Recent studies have focused on optimizing the efficacy and reducing side effects of this compound, showing a promising area for chemical innovation and development.
  • Structural Complexity: With multiple functional groups, this compound exemplifies the importance of structure-activity relationships (SAR) in medicinal chemistry, guiding researchers in the design of new drugs.

As a prospective scientist, understanding 2-[[4-(Acetylsulfamoyl)phenyl]carbamoyl]benzoic acid opens doors to not only new therapeutic avenues but also deeper insights into chemical interactions and the importance of functional group positioning within molecular structures.

In the words of a renowned chemist, "Chemistry is not just about molecules; it’s about understanding the stories they tell us about the world around us."

Synonyms
PHTHALYLSULFACETAMIDE
131-69-1
Tamid
Enterosulfamid
Ftalicetimida
Enterocid
Enterosulfon
Sulphalyl
Talicetimida
Talsigel
Thalocid
Phthalylsulphacetamide
Enterosulphamid
Kalacet
Rabalan
Sterathal
Talasulfa
Talecid
Talsutin
Thalajen
Thalamyd
Thalisul
Phthaloylsulfacetamide
Phthalylsulfacetamid
Phthalylsulfacetimide
Phthalylthioacetamide
Enteramide
4'-(Acetylsulfamoyl)phthalanilic acid
TSC-80
N-(o-Carboxybenzoyl)sulfacetamide
TSC-80 Medicated
Phthalylsulfanilazetamid
Benzoic acid, 2-[[[4-[(acetylamino)sulfonyl]phenyl]amino]carbonyl]-
Phthalanilic acid, 4'-(acetylsulfamoyl)-
UNII-24PUW23GRX
2-[[4-(acetylsulfamoyl)phenyl]carbamoyl]benzoic acid
24PUW23GRX
4'-(Acetylsulfamyl)phthalanilic acid
NSC 163977
NSC-163977
Phthalylsulfacetamide [BAN:NF]
N(sup1)-Acetyl-N(sup4)-phthalylsulfanilamide
EINECS 205-035-7
2-((4-(N-Acetylsulfamoyl)phenyl)carbamoyl)benzoic acid
AI3-24457
DTXSID9059620
PHTHALYLSULFACETAMIDE [MI]
N1-Acetyl-N4-phthalylsulfanilamide
PHTHALYLSULFACETAMIDE [MART.]
NSC163977
PHTHALYLSULFACETAMIDE [WHO-DD]
Benzoic acid, 2-(((4-((acetylamino)sulfonyl)phenyl)amino)carbonyl)-
PHTHALYLSULFACETAMIDE (MART.)
SR-01000254500
2-{[4-(acetylsulfamoyl)phenyl]carbamoyl}benzoic acid
MFCD00020275
N-(4-(Acetylsulphamoyl)phenyl)phthalamic acid
Oprea1_188425
Oprea1_615208
SCHEMBL49529
2-{[4-(acetamidosulfonyl)phenyl]carbamoyl}benzoic acid
CHEMBL2106951
DTXCID0034011
NSC4368
CHEBI:135528
HMS1613G10
HMS3264J03
Pharmakon1600-01505728
2-([(4-([Acetylamino]sulfonyl)phenyl)amino]carbonyl)benzoic acid
HY-B0967
NSC-4368
NSC759234
STK047385
AKOS000490188
CCG-213977
CS-4452
NSC-759234
BS-14902
DA-66690
Phthalylsulfacetamide, analytical standard
SBI-0207072.P001
NS00009830
SW220058-1
C72280
AB01563234_01
AB01563234_02
SR-01000254500-1
SR-01000254500-2
SR-01000254500-3
BRD-K77115421-001-02-6
BRD-K77115421-001-03-4
BRD-K77115421-001-04-2
Q27253867
2-({4-[(Acetylamino)sulfonyl]anilino}carbonyl)benzoic acid
2-((4-[(Acetylamino)sulfonyl]anilino)carbonyl)benzoic acid #
2-[[[4-[(Acetylamino)sulfonyl]phenyl]amino]carbonyl]-benzoic acid
BENZOIC ACID,2-[[[4-[(ACETYLAMINO)SULFONYL]PHENYL]AMINO]CARBONYL]-
205-035-7