Skip to main content

2-(4-allyloxy-3-chlorophenyl)ethanehydroxamic acid

ADVERTISEMENT
Identification
Molecular formula
C11H12ClNO3
CAS number
344458-19-5
IUPAC name
2-(4-allyloxy-3-chloro-phenyl)ethanehydroxamic acid
State
State

2-(4-allyloxy-3-chlorophenyl)ethanehydroxamic acid is typically a solid at room temperature. It may require specific conditions to maintain its stability and prevent decomposition.

Melting point (Celsius)
220.00
Melting point (Kelvin)
493.00
Boiling point (Celsius)
480.00
Boiling point (Kelvin)
753.00
General information
Molecular weight
241.68g/mol
Molar mass
241.6900g/mol
Density
1.4000g/cm3
Appearence

The compound appears as a solid with a crystalline structure. Its color can range from white to off-white, depending on the purity and specific conditions of crystallization.

Comment on solubility

Solubility of 2-(4-allyloxy-3-chloro-phenyl)ethanehydroxamic acid

2-(4-allyloxy-3-chloro-phenyl)ethanehydroxamic acid is a compound with intriguing solubility characteristics influenced by its unique chemical structure. Solubility can depend on various factors, including solvents used, temperature, and the presence of other solutes. Here are some key points to consider:

  • Polarity: The presence of hydroxamic acid functionality typically enhances the polarity of the compound, making it more soluble in polar solvents like water and methanol.
  • Hydrogen Bonding: The hydroxamic acid group can participate in hydrogen bonding, which can further facilitate solubility in polar environments by interacting with solvent molecules.
  • Aromatic Substituents: The aromatic rings may introduce some hydrophobic characteristics, potentially decreasing solubility in polar solvents and increasing it in non-polar solvents such as chloroform or ethyl acetate.
  • Temperature Dependency: As with many organic compounds, increased temperature may enhance solubility by providing the kinetic energy needed to overcome intermolecular forces.

In summary, while potential solubility in polar solvents is indicated by the presence of the hydroxamic acid group, the overall behavior in solution will require experimental validation. It is often said that "solubility is an expression of chemical compatibility," and this compound exemplifies the balance between hydrophilic and hydrophobic character that defines its solubility profile.

Interesting facts

Interesting Facts about 2-(4-allyloxy-3-chloro-phenyl)ethanehydroxamic acid

2-(4-allyloxy-3-chloro-phenyl)ethanehydroxamic acid is a unique compound that combines the functional properties of hydroxamic acids with intriguing organic structures. Here are some standout features:

  • Hydroxamic Acid Functionality: This compound belongs to a class of compounds known as hydroxamic acids, which possess a functional group that is pivotal in various biological processes. Hydroxamic acids are often recognized for their ability to inhibit metalloprotein enzymes, making them a point of interest in drug discovery.
  • Pharmacological Potential: Compounds like 2-(4-allyloxy-3-chloro-phenyl)ethanehydroxamic acid can have significant implications in medicinal chemistry. The structural motifs present may lead to activity against certain cancers and in the treatment of various diseases due to their potential to interact with critical biological targets.
  • Versatile Synthetic Pathways: The synthetic routes to create this compound often involve interesting organic transformations where functional groups can be manipulated, allowing chemists to explore the design of related derivatives that might enhance its bioactivity.
  • Environmental Impact: Understanding the behavior of this compound in biological systems is crucial not only for its therapeutic applications but also for assessing its environmental impact, particularly if it were to enter ecosystems through pharmaceutical waste.

As with many synthetic compounds, ongoing research aims to deepen our understanding of 2-(4-allyloxy-3-chloro-phenyl)ethanehydroxamic acid. The intersection of its chemical reactivity with biological activity makes it a rich area for study in fields ranging from organic synthesis to pharmacognosy.

In the words of a wise chemist, “The beauty of chemistry lies in its ability to connect molecular structures to their vast applications in real-world scenarios.”

Synonyms
19623-05-3
BRN 2218154
2-(4-Allyloxy-3-chlorophenyl)acetohydroxamic acid
ACETOHYDROXAMIC ACID, 2-(4-ALLYLOXY-3-CHLOROPHENYL)-
Benzeneacetamide, 3-chloro-N-hydroxy-4-(2-propenyloxy)-
DTXSID20173301
DTXCID6095792
RefChem:316785
2-(3-chloro-4-prop-2-enoxyphenyl)-N-hydroxyacetamide
3-Chloro-N-hydroxy-4-(2-propenyloxy)benzeneacetamide