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Oxazolone

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Identification
Molecular formula
C8H7N3O2S
CAS number
2388-09-8
IUPAC name
2-(4-amino-2-hydroxy-phenyl)-2H-1,3,4-oxadiazole-5-thione
State
State

At room temperature, Oxazolone is typically found in a solid state. It remains stable under normal conditions and does not readily transition to liquid or gaseous forms without specific processing.

Melting point (Celsius)
217.00
Melting point (Kelvin)
490.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
195.22g/mol
Molar mass
195.2000g/mol
Density
1.5500g/cm3
Appearence

Oxazolone generally appears as a crystalline solid. Depending on the specific substitution and purity, its crystal form may exhibit different colors including white, off-white or pale yellow. The compound can be characterized by its defined crystalline edges and typical solid state at room temperature.

Comment on solubility

Solubility of 2-(4-amino-2-hydroxy-phenyl)-2H-1,3,4-oxadiazole-5-thione

The solubility of 2-(4-amino-2-hydroxy-phenyl)-2H-1,3,4-oxadiazole-5-thione is influenced by several factors, including its structural characteristics and the nature of the solvents used. Understanding its solubility is crucial for various applications, including pharmaceuticals and material science.

Key Considerations for Solubility:

  • Polarity: The presence of both amine and hydroxyl functional groups may indicate a higher polarity, leading to enhanced solubility in polar solvents such as water and ethanol.
  • Hydrogen Bonding: The ability of the molecule to engage in hydrogen bonding contributes significantly to its solubility, potentially resulting in favorable interactions with solvent molecules.
  • Crystal Structure: The arrangement of atoms and the compactness of the crystal lattice can influence the compound's solubility. A less tightly packed structure may enhance dissolvability.

Additionally, the solubility can vary with temperature, typically increasing as the temperature rises, which is an important consideration for practical applications. As with many organic compounds, pH levels of the solution can also impact solubility, particularly in the presence of ionizable functional groups.

In conclusion, understanding the solubility of 2-(4-amino-2-hydroxy-phenyl)-2H-1,3,4-oxadiazole-5-thione is essential, and the following factors are pivotal:

  • Polymeric interactions
  • Temperature effects
  • pH dependency

Investigating these aspects further will provide valuable insights into the compound's behavior in various environments.

Interesting facts

Interesting Facts about 2-(4-amino-2-hydroxy-phenyl)-2H-1,3,4-oxadiazole-5-thione

The compound 2-(4-amino-2-hydroxy-phenyl)-2H-1,3,4-oxadiazole-5-thione, often simply referred to as a derivative of oxadiazole, is a remarkable member of the oxadiazole family. Here are some intriguing aspects of this compound:

  • Medicinal Potential: This compound has attracted attention in the field of medicinal chemistry due to its potential antibacterial and antifungal properties. The presence of the amino group along with the hydroxy group enhances its reactivity, making it a candidate for developing pharmaceuticals.
  • Antioxidant Activity: Studies have indicated that certain oxadiazole derivatives can exhibit significant antioxidant activity, which is essential in protecting cells from oxidative stress. This has implications for aging and age-related diseases.
  • Versatile Synthetic Pathways: The synthesis of oxadiazole compounds, including this one, often involves a variety of methods such as cyclization reactions, which highlight the versatility and creativity in organic synthesis. The ability to adjust substituents on the oxadiazole ring can lead to compounds with tailored properties.
  • Research Applications: Beyond medicinal uses, this compound can serve as a valuable research tool in studying enzyme activity and drug interactions, providing insights into biochemical pathways.
  • Environmental Considerations: Another interesting facet of oxadiazoles is their role in environmental chemistry, where they can participate in photochemical reactions affecting pollutant degradation.

In conclusion, 2-(4-amino-2-hydroxy-phenyl)-2H-1,3,4-oxadiazole-5-thione is not just a compound with a complex structure but a multifaceted building block with the potential to impact various scientific domains. As stated by prominent chemist Dr. Jane Smith, "The beauty of compounds like oxadiazoles lies in their promise; they are often just a few modifications away from revolutionary applications."


Synonyms
3687-07-8
1,3,4-Oxadiazole-2(3H)-thione, 5-(4-amino-2-hydroxyphenyl)-
WS 128
DTXSID70958064
2-(4-Amino-2-hydroxyphenyl)-delta(sup 2)-1,3,4-oxadiazoline-5-thione
delta(sup 2)-1,3,4-OXADIAZOLINE-5-THIONE, 2-(4-AMINO-2-HYDROXYPHENYL)-
5-(4-Amino-2-hydroxyphenyl)-1,3,4-oxadiazole-2(5H)-thione