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2-(4-aminophenyl)-1H-benzimidazol-5-amine

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Identification
Molecular formula
C13H12N4
CAS number
74412-85-8
IUPAC name
2-(4-aminophenyl)-3H-benzimidazol-5-amine
State
State

At room temperature, 2-(4-aminophenyl)-1H-benzimidazol-5-amine is in a solid state. The compound remains stable under standard conditions of temperature and pressure.

Melting point (Celsius)
285.00
Melting point (Kelvin)
558.15
Boiling point (Celsius)
600.00
Boiling point (Kelvin)
873.15
General information
Molecular weight
222.27g/mol
Molar mass
222.2700g/mol
Density
1.2760g/cm3
Appearence

2-(4-aminophenyl)-1H-benzimidazol-5-amine typically appears as a solid compound. Its structural characteristics include a benzimidazole ring fused with an aminophenyl group which gives it distinct aromatic properties. The color and texture can vary from off-white to pale yellow crystalline solids depending on purity and form.

Comment on solubility

Solubility of 2-(4-aminophenyl)-3H-benzimidazol-5-amine

The solubility of 2-(4-aminophenyl)-3H-benzimidazol-5-amine is influenced by various factors that are crucial for its applications in different settings. Understanding its solubility can provide insights into its chemical behavior and suitability for various processes.

Key Points about Solubility:

  • Polar vs Nonpolar Solvent: This compound, featuring both amino groups and an aromatic structure, suggests it may have varying solubility in polar and nonpolar solvents.
  • pH Sensitivity: The presence of amine groups often indicates that the solubility can change with pH levels, highlighting the importance of solution conditions.
  • Temperature Dependency: Like many organic compounds, its solubility can significantly change with temperature, typically increasing in higher temperatures.
  • Hydrogen Bonding: The amino groups can engage in hydrogen bonding, which may enhance solubility in hydrogen-bonding solvents.

As noted, "The more functional groups present, the greater the potential for solubility variations." Engaging in proper solvent selection and adjusting environmental conditions will facilitate optimal use of this compound in various chemical applications.

Interesting facts

Interesting Facts about 2-(4-aminophenyl)-3H-benzimidazol-5-amine

2-(4-aminophenyl)-3H-benzimidazol-5-amine, often referred to in scientific literature as an important intermediate in organic synthesis, has garnered attention for its diverse applications in fields ranging from medicinal chemistry to materials science. Here are some compelling insights:

  • Pharmaceutical Potential: This compound is particularly notable for its role in the development of pharmaceuticals. Its structural framework allows for modifications that can enhance biological activity, which stimulates research into its potential as a therapeutic agent.
  • Organic Reaction Intermediate: The presence of both amine and benzimidazole functionalities enables it to undergo various chemical transformations, making it a valuable intermediate in organic synthesis.
  • Research Novelty: According to numerous studies, compounds like 2-(4-aminophenyl)-3H-benzimidazol-5-amine exhibit fascinating properties that warrant further investigation. Recent research has highlighted its potential anti-cancer properties, serving as a scaffold for developing new anticancer drugs.
  • Versatility in Synthesis: The unique structural attributes of this compound allow chemists to explore diverse synthesis pathways, providing ample opportunity for students and researchers to engage in creative problem-solving.

Given its intriguing molecular structure, 2-(4-aminophenyl)-3H-benzimidazol-5-amine exemplifies how small changes in chemical design can lead to substantial differences in functional properties. As one prominent chemist stated, “The magic of chemistry lies in the art of transformation.” This compound truly illustrates that idea, paving the way for advancements in both synthetic methodologies and pharmaceutical development.

Synonyms
7621-86-5
2-(4-Aminophenyl)-1H-benzimidazol-5-amine
2-(4-Aminophenyl)-5-aminobenzimidazole
2-(4-Aminophenyl)-1H-benzimidazol-2-amine
EINECS 231-538-6
NSC 408148
DTXSID0064755
1H-Benzimidazol-6-amine, 2-(4-aminophenyl)-
Benzimidazol-5-amine, 2-(4-aminophenyl)-
DTXCID1047865
231-538-6
xafotxwpfvzqaz-uhfffaoysa-n
2-(4-Aminophenyl)-1H-benzo[d]imidazol-5-amine
1H-Benzimidazol-5-amine, 2-(4-aminophenyl)-
5-amino-2-(4-aminophenyl)benzimidazole
2-(4-aminophenyl)-3H-benzimidazol-5-amine
2-(4-Amino-phenyl)-3H-benzoimidazol-5-ylamine
Benzimidazole, 5-amino-2-(p-aminophenyl)-
MLS000764524
2-(4-aminophenyl)-1H-1,3-benzodiazol-5-amine
SMR000290129
2-(4-Aminophenyl)-1H- benzimidazol-5-amine (APBIA)
MFCD00451475
NSC408148
5-amino-2-(p-aminophenyl)benzimidazole
Cambridge id 5137121
2-(4-aminophenyl)-1H-1,3-benzodiazol-6-amine
Oprea1_073783
Oprea1_196638
Oprea1_357955
CBDivE_010161
cid_24260
SCHEMBL159873
CHEMBL1489074
SCHEMBL15144987
BDBM53882
HMS2667O03
HAA62186
CCG-15105
MFCD00043996
STK266257
AKOS000115437
AKOS000601336
NSC-408148
2-(4-aminophenyl)-6-aminobenzimidazole
2-(p-aminophenyl)-5-aminobenzimidazole
NCGC00245118-01
2-(4-aminophenyl)-6-amino benzimidazole
2-(4-aminophenyl)-6-amino-benzimidazole
5-Amino-2-(4-aminophenyl)-benzimidazole
AS-66542
BP-13089
SY055299
2-(4'-aminophenyl) 5-amino benzimidazole
DB-003864
2-(4'-amino-phenyl)-5-amino-benzimidazole
A2759
CS-0095841
NS00037765
EN300-02411
F15111
[4-(6-amino-1H-benzimidazol-2-yl)phenyl]amine
SR-01000389407
SR-01000389407-1
Z56862335