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Carbutamide

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Identification
Molecular formula
C12H17N3O4
CAS number
5574-97-0
IUPAC name
2-(4-aminophenyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol
State
State

Carbutamide is a solid at room temperature. It is typically provided as a crystalline powder and is usually stable under normal conditions of use.

Melting point (Celsius)
148.00
Melting point (Kelvin)
421.15
Boiling point (Celsius)
284.00
Boiling point (Kelvin)
557.15
General information
Molecular weight
378.42g/mol
Molar mass
378.4230g/mol
Density
1.2100g/cm3
Appearence

Carbutamide appears as a white to off-white crystalline powder. It is generally odorless and has a slightly bitter taste. It is known to darken upon exposure to light, so it should be stored in a light-resistant container.

Comment on solubility

Solubility of 2-(4-aminophenyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol

The solubility of 2-(4-aminophenyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol (C12H17N3O4) is influenced by several factors, primarily its molecular structure and functional groups. This compound exhibits a moderate level of solubility in various solvents due to the presence of both polar and non-polar characteristics within its structure.

Key Factors Affecting Solubility:

  • Polar Functional Groups: The presence of hydroxymethyl (-CH2-OH) and amino (-NH2) groups contribute to hydrogen bonding, enhancing solubility in polar solvents like water.
  • Hydrophobic Regions: The aromatic ring structure may introduce hydrophobic character, potentially decreasing solubility in highly polar solvents.
  • pH Sensitivity: Changes in pH can affect the ionization of the amino group, influencing solubility in aqueous solutions.

This compound is likely to be more soluble in alcohols and other polar organic solvents than in non-polar solvents, emphasizing the importance of solvent choice in practical applications. Furthermore, the solubility can be described as varying with temperature, so it is essential to consider these factors when conducting experiments or formulating products involving this compound.


In summary, the interplay of polar and hydrophobic characteristics makes 2-(4-aminophenyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol an interesting compound with notable solubility properties that can be leveraged in various chemical and pharmaceutical applications.

Interesting facts

Interesting Facts about 2-(4-aminophenyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol

This intriguing compound, known for its unique structure and functionalities, belongs to a class of molecules that exhibits significant biological activity. Here are some key insights:

  • Pharmacological Potential: The compound’s structure suggests potential interactions with various biological targets, making it a subject of interest in drug discovery research.
  • Amine Functional Group: The presence of the aminophenyl group may contribute to its ability to interact with nitrogen-containing receptors in drug metabolism and pharmacodynamics.
  • Hydroxymethyl Functionality: The hydroxymethyl group is critical for enhancing water solubility and can improve the bioavailability of the compound, which is vital when it comes to pharmacological applications.
  • Chirality: As a pyrrolidine derivative, this compound exhibits chirality, which can lead to different biological activities depending on the stereochemistry of the molecule. This aspect makes it crucial to study its enantiomers carefully.

As noted by researchers, compounds that exhibit dual functionalities, like this pyrrolidine derivative, often show promise in multifaceted therapeutic areas. Quotes such as, "The design of compounds with multiple sites for interaction is a cornerstone of modern medicinal chemistry," further underscore the importance of molecules like this in the development of new therapies.

In conclusion, 2-(4-aminophenyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol stands as a fascinating subject for further exploration, offering insights not just into its inherent properties but also into the wider potential applications within pharmaceutical science.

Synonyms
2-(4-aminophenyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol
188745-06-4
3,4-Pyrrolidinediol, 2-(4-aminophenyl)-5-(hydroxymethyl)-, (2S,3S,4R,5R)-
DTXSID70274312
SQENVZNKXLCDLF-UHFFFAOYSA-N