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Ketoprofen

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Identification
Molecular formula
C16H14O3
CAS number
22071-15-4
IUPAC name
2-(4-benzylphenyl)-1-hydroxy-2-oxo-ethanesulfonic acid
State
State

Ketoprofen is typically found as a solid at room temperature.

Melting point (Celsius)
94.00
Melting point (Kelvin)
367.15
Boiling point (Celsius)
580.00
Boiling point (Kelvin)
853.15
General information
Molecular weight
254.28g/mol
Molar mass
254.2810g/mol
Density
1.2010g/cm3
Appearence

Ketoprofen appears as a white or off-white crystalline powder.

Comment on solubility

Solubility of 2-(4-benzylphenyl)-1-hydroxy-2-oxo-ethanesulfonic acid

The compound 2-(4-benzylphenyl)-1-hydroxy-2-oxo-ethanesulfonic acid exhibits interesting solubility characteristics which are important for various applications. Here are some key points to consider:

  • Polar Nature: Due to the presence of sulfonic acid groups, this compound tends to be polar, which generally enhances its solubility in water.
  • Hydrogen Bonding: The ability to form hydrogen bonds with water molecules contributes significantly to its solubility. This can lead to increased dissolution rates in aqueous environments.
  • Organic Solvents: The presence of the bulky benzyl group may limit solubility in certain organic solvents, but it can still dissolve in polar aprotic solvents like DMSO and DMF.
  • pH Dependence: The solubility of this compound may vary with pH; at lower pH levels, the sulfonic acid group is protonated, potentially affecting its water solubility.

In summary, while 2-(4-benzylphenyl)-1-hydroxy-2-oxo-ethanesulfonic acid demonstrates good solubility in water due to its polar nature and ability to form hydrogen bonds, it may have variable solubility in other solvents. This understanding of solubility is crucial for its utilization in chemical applications and formulations.

Interesting facts

Interesting Facts about 2-(4-benzylphenyl)-1-hydroxy-2-oxo-ethanesulfonic acid

2-(4-benzylphenyl)-1-hydroxy-2-oxo-ethanesulfonic acid is a fascinating compound with unique characteristics that make it an interesting subject of study in the field of chemistry. Here are some noteworthy points:

  • Pharmaceutical Applications: This compound is particularly relevant in pharmaceutical chemistry due to its potential use in drug formulations. Its sulfonic acid group is known to enhance solubility and bioavailability, which are critical factors for drug efficacy.
  • Structural Complexity: The structure of this compound showcases the combination of a sulfonic acid moiety with a hydroxy and ketone functionality, resulting in a versatile molecule capable of participating in various chemical reactions and interactions.
  • Research Potential: Scientists are exploring the implications of compounds like this in therapeutic agents. Research continues to unveil how such structures can potentially interact with biological systems, leading to the development of new medications.
  • Importance of Benzyl Groups: The presence of the 4-benzylphenyl group is significant. Benzyl groups are known for their ability to stabilize charge during chemical reactions, which could be beneficial for catalytic processes and organic synthesis.
  • Environmental Impact: Understanding compounds that contain sulfonic acid groups is becoming increasingly important in environmental chemistry, particularly concerning their behavior and transformation in different ecosystems.

As emphasized by many chemists, “The complexity of a molecule often dictates its behavior and reactivity in both synthetic pathways and biological systems.” This compound illustrates the intricate balance between structure and function, making it an excellent candidate for further investigation.

Overall, 2-(4-benzylphenyl)-1-hydroxy-2-oxo-ethanesulfonic acid serves not only as an intriguing chemical species but also as a testament to the rich interplay of organic and medicinal chemistry.

Synonyms
(4-Benzyl-phenyl)-oxo-acetaldehyde, bisulfite
2-(4-benzylphenyl)-1-hydroxy-2-oxo-ethanesulfonic acid
2-(4-Benzyl-phenyl)-1-hydroxy-2-oxo-ethanesulfonic acid