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Nitrofurantoin

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Identification
Molecular formula
C8H6N4O5
CAS number
67-20-9
IUPAC name
2-(4-benzylpiperazin-1-yl)-N-[(5-nitro-2-furyl)methyleneamino]acetamide
State
State

At room temperature, nitrofurantoin is typically a solid. It is stable under standard conditions of temperature and pressure.

Melting point (Celsius)
269.80
Melting point (Kelvin)
542.90
Boiling point (Celsius)
498.60
Boiling point (Kelvin)
771.80
General information
Molecular weight
238.16g/mol
Molar mass
238.1560g/mol
Density
1.6669g/cm3
Appearence

Nitrofurantoin is a yellow, crystalline compound. It may appear as a fine or coarse powder that has a bitter taste. It is quite distinctive due to its specific color as a solid.

Comment on solubility

Solubility of 2-(4-benzylpiperazin-1-yl)-N-[(5-nitro-2-furyl)methyleneamino]acetamide

The solubility of 2-(4-benzylpiperazin-1-yl)-N-[(5-nitro-2-furyl)methyleneamino]acetamide is an intriguing aspect worthy of exploration. This compound, featuring a complex structure, can exhibit varying solubility properties depending on its environment.

Factors Influencing Solubility

Key factors that influence the solubility of this compound include:

  • Polarity: The presence of polar functional groups may increase the solubility in polar solvents.
  • Hydrogen bonding: Ability to form hydrogen bonds can enhance solubility, especially in water.
  • Temperature: Higher temperatures often increase solubility for many compounds.
  • pH Levels: The ionization state of the compound can change with pH, affecting its solubility in aqueous solutions.

It is noteworthy that compounds with such complex structures may demonstrate limited solubility in typical organic solvents, which demands careful consideration when preparing solutions for experimental purposes. Therefore, testing in a range of solvents is advisable to determine solubility profiles adequately.

General Observations

In summary, the solubility characteristics of 2-(4-benzylpiperazin-1-yl)-N-[(5-nitro-2-furyl)methyleneamino]acetamide can be summarized as:

  • Variable solubility influenced by solvent choice and environmental conditions.
  • Potentially limited solubility in common organic solvents.
  • A necessity for empirical solubility testing to define practical use in formulations.

Understanding the solubility of this compound lays the foundation for its potential applications in various fields, making it a subject of continued interest in chemical research.

Interesting facts

Interesting Facts about 2-(4-benzylpiperazin-1-yl)-N-[(5-nitro-2-furyl)methyleneamino]acetamide

This intriguing compound is an example of a multifunctional molecule that has gained interest in various fields, notably medicinal chemistry and drug development. Here are some fascinating aspects to consider:

  • Versatile Structure: The compound features structural motifs that have been associated with a range of biological activities. The incorporation of a 5-nitro-2-furyl group is particularly notable, as furan derivatives are often investigated for their *antimicrobial* and *anti-inflammatory* properties.
  • Role of the Benzylpiperazine Moiety: The presence of the 4-benzylpiperazine structure is significant because piperazine derivatives frequently exhibit *antidepressant* and *antipsychotic* effects, suggesting potential therapeutic applications.
  • Targeting Biological Pathways: This compound exemplifies how specific structural modifications can influence the compound's ability to interact with neurotransmitter receptors or enzymes, which is a vital consideration in drug design.
  • Applications in Research: Scientists are exploring analogues of this compound for their ability to modulate natural pathways in the body, particularly in areas like *cancer research* and *neurology*.

As a testament to the complexity of chemical research, the development of compounds such as 2-(4-benzylpiperazin-1-yl)-N-[(5-nitro-2-furyl)methyleneamino]acetamide highlights the intricate relationships between structure and activity. The ongoing investigation into these interactions continues to spark excitement within the scientific community.

Overall, this compound serves as a reminder of the potential that lies within the molecular framework of chemistry to address some of humanity's most pressing health challenges.