Skip to main content

Chlorambucil

ADVERTISEMENT
Identification
Molecular formula
C14H19Cl2NO2
CAS number
305-03-3
IUPAC name
2-[4-[bis(2-chloroethyl)amino]phenoxy]acetic acid
State
State

Chlorambucil is a solid at room temperature. It is typically handled and used in controlled medical environments due to its application and properties.

Melting point (Celsius)
65.00
Melting point (Kelvin)
338.15
Boiling point (Celsius)
400.00
Boiling point (Kelvin)
673.15
General information
Molecular weight
304.20g/mol
Molar mass
304.1950g/mol
Density
1.2000g/cm3
Appearence

Chlorambucil appears as a white to pale yellow crystalline powder. It is often found in a form suitable for oral administration as it is used primarily in chemotherapy treatments.

Comment on solubility

Solubility of 2-[4-[bis(2-chloroethyl)amino]phenoxy]acetic acid

2-[4-[bis(2-chloroethyl)amino]phenoxy]acetic acid, often referred to for its complex chemical structure, exhibits notable solubility characteristics. Understanding its solubility is crucial for applications in various fields. Here are some key points to consider:

  • Polarity: The presence of the amino and carboxylic acid functional groups contributes to its polarity, enhancing its ability to dissolve in polar solvents such as water.
  • Organic Solvents: In addition to its solubility in water, this compound is typically more soluble in organic solvents, which may include ethanol and dimethyl sulfoxide (DMSO).
  • pH Influence: The solubility can be influenced by pH levels; at different pH conditions, the degree of ionization of the acid group can vary, affecting solubility in aqueous solutions.
  • Temperature Effects: Generally, an increase in temperature tends to enhance the solubility of many compounds, and this specific acid may follow that trend.

In conclusion, while 2-[4-[bis(2-chloroethyl)amino]phenoxy]acetic acid is generally deemed soluble in polar environments, it is essential to consider its interaction with specific solvents and conditions for optimal usage.

Interesting facts

Interesting Facts about 2-[4-[bis(2-chloroethyl)amino]phenoxy]acetic acid

2-[4-[bis(2-chloroethyl)amino]phenoxy]acetic acid is a fascinating compound primarily recognized for its role in medicinal chemistry. This compound exhibits properties that have made it a subject of study for its potential therapeutic applications.

Key Attributes

  • Potential Anti-Cancer Activity: The 2-chloroethyl amine moiety is often associated with alkylating agents that can interfere with DNA synthesis. This makes the compound a candidate for further studies in cancer treatment.
  • Mechanism of Action: Compounds with a similar structure typically work by forming cross-links in DNA, thereby inhibiting cell division and promoting apoptosis in malignant cells.
  • Synthesis Insights: The synthesis of this compound often involves intricate organic reactions and can serve as an excellent learning tool for students interested in organic chemistry techniques.

Researchers are particularly intrigued by the compound due to its dual functional groups; the phenoxy group enhances solubility while the acetic acid tail contributes to its bioactivity. This design reflects a carefully constructed balance of chemical properties aimed at maximizing therapeutic effectiveness.

Furthermore, the study of 2-[4-[bis(2-chloroethyl)amino]phenoxy]acetic acid underscores the importance of structure-activity relationships (SAR) in drug design. As we explore this compound, we gain insights into how slight modifications can significantly impact biological effects. As one researcher noted, “Understanding the relationship between structure and function is essential in the quest for effective pharmaceuticals.”

Conclusion

In conclusion, 2-[4-[bis(2-chloroethyl)amino]phenoxy]acetic acid exemplifies the intricate interplay of chemistry and biology. As more research unravels its complete profile, this compound may not just be a chemical entity, but a beacon of hope in the realm of therapeutic development.

Synonyms
17528-53-9
4-N,N-Bis(2-chloroethyl)aminophenoxyacetic acid
ACETIC ACID, (p-(BIS(2-CHLOROETHYL)AMINO)PHENOXY)-
(p-(Bis(2-chloroethyl)amino)phenoxy)acetic acid
p-N,N-Bis(2-chloroethyl)aminophenoxyacetic acid
Acetic acid, (4-(bis(2-chloroethyl)amino)phenoxy)-
(4-bis(2-chloroethyl)aminophenoxy)acetic acid
NSC-42342
Acetic acid, (4-bis(2-chloroethyl)amino)phenoxy-
DTXSID00169964
LUL2A38995
CB-1360
Acetic acid, [4-bis(2-chloroethyl)amino]phenoxy-
Acetic acid, (p-[bis(2-chloroethyl)amino]phenoxy)-
4-NNBCAPA
DTXCID0092455
MP 571
2-[4-[bis(2-chloroethyl)amino]phenoxy]acetic acid
CCRIS 6873
CB 1360
NSC 42342
BRN 2865618
p-N,N-Bis(2-chlroethyl)aminophenoxyacetic acid
SCHEMBL7461415
IVWVTSYBZDGRSH-UHFFFAOYSA-N
NSC42342
[p-[bis(2-chloroethyl)amino]phenoxy] acetic acid
4-[N,N-Bis(2-chloroethyl)amino]phenoxyacetic acid
Acetic acid, 2-[4-[bis(2-chloroethyl)amino]phenoxy]-