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2-[4-bromo-2-(1-piperidylmethyl)phenoxy]acetohydrazide

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Identification
Molecular formula
C14H19BrN2O2
CAS number
313513-92-9
IUPAC name
2-[4-bromo-2-(1-piperidylmethyl)phenoxy]acetohydrazide
State
State

The compound is solid at room temperature with a crystalline structure. It is not highly volatile and remains in this state under typical laboratory conditions.

Melting point (Celsius)
140.50
Melting point (Kelvin)
413.65
Boiling point (Celsius)
392.50
Boiling point (Kelvin)
665.65
General information
Molecular weight
344.23g/mol
Molar mass
344.2350g/mol
Density
1.4200g/cm3
Appearence

2-[4-bromo-2-(1-piperidylmethyl)phenoxy]acetohydrazide appears as an off-white to pale yellow solid. The compound is generally in a crystalline form and may possess a slight odor due to the presence of the piperidyl group.

Comment on solubility

Solubility of 2-[4-bromo-2-(1-piperidylmethyl)phenoxy]acetohydrazide

The solubility of 2-[4-bromo-2-(1-piperidylmethyl)phenoxy]acetohydrazide is an important aspect worth exploring for its applications in various fields. This compound, which contains a complex aromatic structure, displays unique solubility characteristics that can be summarized as follows:

  • Polarity: The presence of functional groups, particularly the hydrazide and phenoxy moieties, influences the polarity of the compound which can aid in solubility in polar solvents.
  • Solvent Compatibility: Typically, compounds with significant aromatic content are more soluble in organic solvents such as dichloromethane and ethanol rather than water, due to their hydrophobic nature.
  • Temperature Effects: Solubility can generally increase with temperature. Thus, heating the solvent can often enhance the dissolution of such compounds.
  • Hydrogen Bonding: The presence of functional groups capable of forming hydrogen bonds may also enhance solubility in polar solvents, although this needs to be balanced against the overall hydrophobic characteristics of the compound.

In conclusion, understanding the solubility of 2-[4-bromo-2-(1-piperidylmethyl)phenoxy]acetohydrazide is crucial for practical applications, as it dictates its behavior in various environments. "Like dissolves like" is a key principle here – the solubility largely depends on the polarity and structure of the solvent used. Therefore, further experimental studies are recommended to determine the specific solubility properties under varied conditions.

Interesting facts

Interesting Facts about 2-[4-bromo-2-(1-piperidylmethyl)phenoxy]acetohydrazide

This intriguing compound belongs to a class of **acetohydrazides**, known for their diverse biological activities and potential therapeutic applications. Here are some fascinating insights into 2-[4-bromo-2-(1-piperidylmethyl)phenoxy]acetohydrazide:

  • Structure and Functionality: The presence of a bromo group on the phenyl ring enhances the compound's reactivity and biological potency, while the piperidylmethyl moiety may contribute to its ability to penetrate biological membranes, making it potentially useful in drug design.
  • Biological Activity: Compounds of this class often exhibit activity against various forms of cancer, inflammation, and microbial infections. Researchers are increasingly interested in synthesizing derivatives of acetohydrazides to explore their pharmacological properties.
  • Synthetic Pathways: The synthesis of acetohydrazides typically involves the reaction between an acyl hydrazine and a suitable nucleophile. This compound highlights the intricate relationship between structure and reactivity in medicinal chemistry.
  • Pharmaceutical Potential: As a hydrazide derivative, this compound could be explored for its potential role in the treatment of neurodegenerative diseases or as an anti-tumor agent, showcasing the importance of ongoing research in drug discovery.
  • Research Implications: The unique functionalities provided by the bromo and piperidine groups make this compound an exciting candidate for studying structure-activity relationships (SAR) in medicinal chemistry.

In summary, 2-[4-bromo-2-(1-piperidylmethyl)phenoxy]acetohydrazide is more than just a chemical formula; it represents the confluence of organic synthesis, medicinal chemistry, and pharmacology. As scientists continue to unveil its secrets, this compound may lead to significant advancements in therapeutic interventions.

Synonyms
ACETIC ACID, ((4-BROMO-alpha-PIPERIDINO-o-TOLYL)OXY)-, HYDRAZIDE
16158-18-2
(4-Bromo-2-(1-piperidinylmethyl)phenoxy)acetic acid hydrazide
BRN 1258504
Acetic acid, (4-bromo-2-(1-piperidinylmethyl)phenoxy)-, hydrazide
DTXSID80167201