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2-(4-Butoxy-3-chlorophenyl)ethanohydroxamic acid

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Identification
Molecular formula
C12H16ClNO3
CAS number
865604-58-6
IUPAC name
2-(4-butoxy-3-chloro-phenyl)ethanehydroxamic acid
State
State

The compound is a solid at room temperature, typically found in a crystalline form.

Melting point (Celsius)
142.00
Melting point (Kelvin)
415.15
Boiling point (Celsius)
372.00
Boiling point (Kelvin)
645.15
General information
Molecular weight
257.72g/mol
Molar mass
257.7200g/mol
Density
1.2500g/cm3
Appearence

The compound appears as a white to off-white crystalline solid.

Comment on solubility

Solubility of 2-(4-butoxy-3-chloro-phenyl)ethanehydroxamic acid

The solubility of 2-(4-butoxy-3-chloro-phenyl)ethanehydroxamic acid is influenced by several factors, making it a compound of interest for solubility studies.

  • Polarity: Due to the presence of both hydrophobic (butoxy group) and hydrophilic (hydroxamic acid group) moieties, the compound exhibits a unique balance in polarity. The hydroxamic acid group can interact with water through hydrogen bonding, enhancing solubility in polar solvents. Meanwhile, the butoxy group may hinder solubility in water.
  • Solvent Type: It is likely to be more soluble in organic solvents such as ethanol and DMSO, while showing limited solubility in water. This can be attributed to the hydrophobic character of the butoxy group.
  • pH Dependence: The solubility may also vary with pH, as the ionization of the hydroxamic acid can affect solubility. At different pH levels, the compound may exist in its ionized form, which could enhance solubility in aqueous solutions.

In conclusion, understanding the solubility of 2-(4-butoxy-3-chloro-phenyl)ethanehydroxamic acid requires considering multiple factors such as its molecular structure, the nature of the solvent, and environmental conditions like pH. These characteristics make it a fascinating compound for further research.

Interesting facts

Interesting Facts about 2-(4-butoxy-3-chloro-phenyl)ethanehydroxamic acid

2-(4-butoxy-3-chloro-phenyl)ethanehydroxamic acid is a noteworthy compound within the realm of organic chemistry, particularly due to its structure and potential applications. Here are some fascinating insights:

  • Dual Functionality: This compound features both an ethane backbone and a hydroxamic acid functional group, which can enhance its reactivity and integration into various chemical processes.
  • Pharmaceutical Potential: Molecules with hydroxamic acid moieties are often studied for their role as metalloproteinase inhibitors, presenting opportunities for the development of novel therapeutics.
  • Chlorine Substitution: The presence of chlorine in the structure can significantly influence the compound's biological activities, as well as its reactivity. Chlorine is known for enhancing the lipophilicity of compounds, potentially improving their permeability.
  • Role of the Butoxy Group: The butoxy substituent is not just an appendage; it can contribute to the compound's solubility and modify its physicochemical properties, impacting both stability and reactivity.
  • Potential Environmental Impact: With increasing research into the environmental effects of organic compounds, this structure invites analysis regarding its persistence and behavior in biological systems.

In summary, 2-(4-butoxy-3-chloro-phenyl)ethanehydroxamic acid is not just a simple chemical entity, but rather a complex compound with promising applications. Investigating its interactions and properties could lead to significant advancements in fields such as medicinal chemistry and environmental science.

Synonyms
BRN 2863284
15560-60-8
2-(4-Butoxy-3-chlorophenyl)acetohydroxamic acid
ACETOHYDROXAMIC ACID, 2-(4-BUTOXY-3-CHLOROPHENYL)-
DTXSID20165923
DTXCID0088414
SCHEMBL2779953
NCGC00189374-01