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2-(4-butoxy-3-fluorophenyl)ethanehydroxamic acid

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Identification
Molecular formula
C12H16FNO3
CAS number
.null
IUPAC name
2-(4-butoxy-3-fluoro-phenyl)ethanehydroxamic acid
State
State

At room temperature, this compound is in a solid state.

Melting point (Celsius)
152.50
Melting point (Kelvin)
425.65
Boiling point (Celsius)
530.00
Boiling point (Kelvin)
803.15
General information
Molecular weight
251.28g/mol
Molar mass
251.2760g/mol
Density
1.2310g/cm3
Appearence

2-(4-butoxy-3-fluorophenyl)ethanehydroxamic acid is a crystalline solid characterized by its unique structure. It typically appears as a white to slightly off-white powder.

Comment on solubility

Solubility of 2-(4-butoxy-3-fluoro-phenyl)ethanehydroxamic acid

The solubility of 2-(4-butoxy-3-fluoro-phenyl)ethanehydroxamic acid is influenced by several factors, including the molecular structure and the presence of functional groups. This compound demonstrates a range of solubility profiles depending on the solvent used.

Factors Affecting Solubility:

  • Polarity: The presence of the hydroxamic acid group contributes to polar characteristics, enhancing solubility in polar solvents like water.
  • Hydrophobic Alkyl Chain: The butoxy group increases hydrophobic interaction, potentially lowering solubility in highly polar solvents.
  • Temperature: As with many organic compounds, solubility can increase with temperature, allowing for greater dissolution in hot solvent conditions.

In general, this compound may exhibit moderate solubility in aqueous solutions but is likely to be better soluble in organic solvents such as ethanol or methanol. The dual nature of its structure allows it to interact differently in various environments, making empirical testing essential for precise solubility data.

Overall, understanding the solubility characteristics can aid in various applications, including drug formulation and organic synthesis, where solvent choice is crucial.

Interesting facts

Interesting Facts About 2-(4-butoxy-3-fluoro-phenyl)ethanehydroxamic acid

2-(4-butoxy-3-fluoro-phenyl)ethanehydroxamic acid is a fascinating compound that has garnered attention in the fields of medicinal chemistry and pharmacology due to its unique structural characteristics and potential biological activities.

Key Characteristics:

  • Functional Groups: This compound features both a hydroxamic acid group and a butoxy-phenyl moiety, which may influence its solubility and reactivity with biological targets.
  • Fluorine Substitution: The presence of the fluorine atom is noteworthy; it can increase the metabolic stability and bioactivity of the compound by enhancing interactions with biological receptors.
  • Potential Applications: Hydroxamic acids are known for their roles as inhibitors of various enzymes, particularly metalloproteinases, making this compound a subject of interest for therapeutic research.

Researchers are particularly interested in the compound's potential role in:

  • Drug Design: Its structure suggests that it could be tailored to design novel drugs targeting specific diseases.
  • Cancer Research: Given the involvement of metalloproteinases in tumor progression, this compound could be a candidate for anti-cancer drugs.

Scientific Insights:

As noted by prominent chemists, “Understanding the intricate balance of structure and function is paramount in drug discovery.” The unique combination of fluorinated and alkoxy groups in this compound invokes exciting lines of research that explore how subtle changes in chemical structure can lead to significant differences in biological activity.

In summary, 2-(4-butoxy-3-fluoro-phenyl)ethanehydroxamic acid stands out not just for its chemical composition but also for its potential implications in various therapeutic contexts, making it a compelling topic for further investigation in the realm of chemistry and life sciences.

Synonyms
15560-65-3
BRN 2137166
2-(4-Butoxy-3-fluorophenyl)acetohydroxamic acid
ACETOHYDROXAMIC ACID, 2-(4-BUTOXY-3-FLUOROPHENYL)-
DTXSID60165927
DTXCID0088418
2-(4-butoxy-3-fluorophenyl)-N-hydroxyacetamide