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Piribedil

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Identification
Molecular formula
C18H23ClN2O2
CAS number
3605-01-4
IUPAC name
2-(4-butoxyphenoxy)-N-(2-chlorophenyl)-N-(2-pyrrolidin-1-ylethyl)acetamide
State
State

At room temperature, Piribedil is in a solid state. As a crystalline solid, it is often utilized in tablet or another solid form for medical purposes.

Melting point (Celsius)
106.00
Melting point (Kelvin)
379.15
Boiling point (Celsius)
484.90
Boiling point (Kelvin)
758.05
General information
Molecular weight
345.46g/mol
Molar mass
345.4590g/mol
Density
1.1200g/cm3
Appearence

Piribedil appears as a white to off-white crystalline powder. It is relatively soluble in some organic solvents but very sparingly soluble in water, giving it a distinctive pharmaceutical appearance.

Comment on solubility

Solubility of 2-(4-butoxyphenoxy)-N-(2-chlorophenyl)-N-(2-pyrrolidin-1-ylethyl)acetamide

The solubility of 2-(4-butoxyphenoxy)-N-(2-chlorophenyl)-N-(2-pyrrolidin-1-ylethyl)acetamide in various solvents can be influenced by several factors, including its molecular structure and presence of functional groups. Understanding its solubility behavior is crucial for applications in pharmaceutical and industrial chemistry.

Factors Affecting Solubility

  • Molecular Weight: Higher molecular weights may lead to decreased solubility.
  • Functional Groups: The presence of butoxy and chlorophenyl groups can affect interactions with solvents.
  • Hydrophobic vs Hydrophilic Balance: The balance between hydrophobic and hydrophilic characteristics plays a critical role.

Typically, compounds with extensive aromatic systems and long aliphatic chains, like this acetamide, may exhibit limited solubility in water but are often more soluble in organic solvents such as:

  • Ethyl acetate
  • DMSO (dimethyl sulfoxide)
  • Acetone

Thus, it can be stated that 2-(4-butoxyphenoxy)-N-(2-chlorophenyl)-N-(2-pyrrolidin-1-ylethyl)acetamide may display moderate solubility in non-polar or moderately polar solvents, while exhibiting poor solubility in polar solvents like water:

"Understanding solubility is key for predicting the performance of a compound in different environments."

In conclusion, further empirical studies would be beneficial for precise solubility determination in specific solvents, ensuring optimal use in various applications.

Interesting facts

Interesting Facts about 2-(4-butoxyphenoxy)-N-(2-chlorophenyl)-N-(2-pyrrolidin-1-ylethyl)acetamide

This compound, known for its intricate structure and potential applications, holds a fascinating position in the world of chemistry. Here are some key aspects worth noting:

  • A Multifunctional Moiety: The presence of 4-butoxyphenoxy and 2-chlorophenyl components suggests the compound may exhibit various biological activities, making it a subject of interest in medicinal chemistry.
  • Pyrrolidine Influence: The inclusion of a pyrrolidin-1-ylethyl moiety is significant. Pyrrolidine is known for its role in increasing lipophilicity, which can affect the compound's pharmacokinetic properties.
  • Potential Biological Activities: Researchers are intrigued by how alterations in the phenoxy and acetamide groups can influence the molecule's interaction with biological targets, potentially leading to the development of novel therapeutic agents.
  • Structural Variability: The ability to modify substituents on both the aromatic rings and the acetamide group presents an opportunity for structure-activity relationship (SAR) studies, which are essential for drug development.
  • Application in Synthesis: This compound may serve as an intermediate for the synthesis of more complex organic molecules, demonstrating the versatility of amide linkages in modern organic synthesis.

In summary, 2-(4-butoxyphenoxy)-N-(2-chlorophenyl)-N-(2-pyrrolidin-1-ylethyl)acetamide exemplifies how a complex and carefully designed molecular structure can lead to significant biological implications and serve as a foundation for further research and development in pharmaceuticals. As with many chemical entities, its study may reveal exciting pathways to new discoveries!

Synonyms
27585-38-2
ACETANILIDE, 2-(p-BUTOXYPHENOXY)-2'-CHLORO-N-(2-(1-PYRROLIDINYL)ETHYL)-
2-(p-Butoxyphenoxy)-2'-chloro-N-(2-(1-pyrrolidinyl)ethyl)acetanilide
DTXSID00181984
RefChem:315730
DTXCID40104475
2-(4-butoxyphenoxy)-N-(2-chlorophenyl)-N-(2-pyrrolidin-1-ylethyl)acetamide