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Furamizole

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Identification
Molecular formula
C15H22N4O4
CAS number
3683-29-6
IUPAC name
2-(4-butylpiperazin-1-yl)-N-[(5-nitro-2-furyl)methyleneamino]acetamide
State
State

At room temperature, Furamizole is in a solid state and typically exists as a crystalline powder.

Melting point (Celsius)
187.00
Melting point (Kelvin)
460.15
Boiling point (Celsius)
385.00
Boiling point (Kelvin)
658.15
General information
Molecular weight
334.37g/mol
Molar mass
334.3680g/mol
Density
1.3000g/cm3
Appearence

Furamizole typically appears as an off-white to pale yellow crystalline powder. It may have a slight characteristic odor and its appearance might vary slightly depending on the conditions and presence of impurities.

Comment on solubility

Solubility of 2-(4-butylpiperazin-1-yl)-N-[(5-nitro-2-furyl)methyleneamino]acetamide

The solubility of the compound 2-(4-butylpiperazin-1-yl)-N-[(5-nitro-2-furyl)methyleneamino]acetamide can be influenced by several factors, primarily owing to its complex structure. Here's a closer look at the aspects that dictate its solubility:

  • Polarity: Compounds with polar functional groups typically exhibit better solubility in polar solvents, such as water. The presence of both the butylpiperazine and nitrofuryl moieties suggests a potential for moderate to high solubility in aqueous environments.
  • Hydrogen Bonding: The ability to form hydrogen bonds can significantly enhance solubility. In this compound, the amide group is likely to participate in hydrogen bonding, which could facilitate its dissolution in polar solvents.
  • Solvent Interaction: Non-polar components of the butyl chain may lead to decreased solubility in more non-polar solvents, while enhancing solubility in mixed solvents or those mimicking biological conditions.
  • Temperature Effects: As with many organic compounds, temperature plays a vital role. Increased temperature often enhances solubility due to increased molecular motion.

Overall, one might anticipate that 2-(4-butylpiperazin-1-yl)-N-[(5-nitro-2-furyl)methyleneamino]acetamide displays a moderate to good solubility profile in polar solvents, although experimental data would provide a definitive answer. Understanding these solubility characteristics is crucial for applications in pharmaceuticals and other chemical industries, where solubility can be a determining factor in bioavailability and efficacy.

Interesting facts

Interesting Facts about 2-(4-butylpiperazin-1-yl)-N-[(5-nitro-2-furyl)methyleneamino]acetamide

The compound 2-(4-butylpiperazin-1-yl)-N-[(5-nitro-2-furyl)methyleneamino]acetamide presents a fascinating subject of study due to its unique structure and potential applications. Here are some key highlights:

  • Biological Activity: This compound has shown activity as a potential antifungal and antimicrobial agent. Its complex structure allows it to interact with biological targets, making it a candidate for further research in medicinal chemistry.
  • Structure-Activity Relationship: The incorporation of both a piperazine ring and a furan group in its design suggests intricate mechanisms of action. Studying this compound could provide insights into how variations in its structure affect its pharmacological properties.
  • Synthetic Pathways: The synthesis of this compound can involve various organic reactions such as amination and condensation reactions. An understanding of these synthetic methods can enhance the development of similar compounds with improved efficacy.
  • Potential Drug Development: Compounds displaying nitro-furyl derivatives are often further investigated for their use in pharmaceuticals. The nitro group can impart unique chemical reactivity, possibly leading to novel therapeutic agents.
  • Interdisciplinary Applications: Beyond its pharmaceutical potential, this compound may have implications in fields such as materials science and agricultural chemistry, showcasing the versatility of its core structure.

As researchers continue to explore the biological activities and chemical properties of 2-(4-butylpiperazin-1-yl)-N-[(5-nitro-2-furyl)methyleneamino]acetamide, it embodies the excitement and complexity of modern chemistry. It reminds us that even minor modifications in a molecular structure can lead to significantly different outcomes in biological efficacy and application.