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Clotrimazole hydrochloride

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Identification
Molecular formula
C22H30ClN3O3
CAS number
26215-66-7
IUPAC name
2-[(4-chloro-1-tetracyclo[6.6.2.02,7.09,14]hexadeca-2(7),3,5,9,11,13-hexaenyl)oxy]ethyl-dimethyl-ammonium;chloride
State
State
Clotrimazole hydrochloride is solid at room temperature, presenting as a fine powder suitable for pharmaceutical uses.
Melting point (Celsius)
148.00
Melting point (Kelvin)
421.15
Boiling point (Celsius)
230.00
Boiling point (Kelvin)
503.15
General information
Molecular weight
343.29g/mol
Molar mass
343.2940g/mol
Density
1.3000g/cm3
Appearence

Clotrimazole hydrochloride is typically an off-white crystalline powder. It is characterized by its fine particulate form and has no distinct odor.

Comment on solubility

Solubility of 2-[(4-chloro-1-tetracyclo6.6.2.02,7.09,14hexadeca-2(7),3,5,9,11,13-hexaenyl)oxy]ethyl-dimethyl-ammonium;chloride

The solubility of this compound is influenced by its complex structure and functional groups. Generally, the solubility characteristics can be summarized as follows:

  • Polar Nature: The presence of the dimethylammonium group indicates that the compound may possess some degree of polarity, which can enhance solubility in polar solvents, such as water.
  • Hydrophobicity: However, the tetracyclic structure may contribute substantial hydrophobic character, potentially limiting solubility in water.
  • Solvent Compatibility: This compound might be more soluble in organic solvents like ethanol or dimethyl sulfoxide (DMSO), which can accommodate larger hydrophobic moieties.
  • Temperature Dependence: The solubility could increase with temperature, which is typical for many organic compounds.

In summary, while the compound may show some solubility in polar solvents due to ammonium functional groups, its overall solubility will be challenged by its bulky hydrophobic structure. Thorough experimentation is essential to identify the most suitable solvents for optimal solubility.

Interesting facts

Interesting Facts about 2-[(4-chloro-1-tetracyclo[6.6.2.02,7.09,14]hexadeca-2(7),3,5,9,11,13-hexaenyl)oxy]ethyl-dimethyl-ammonium;chloride

This compound is a fascinating member of the chemical realm, especially for its role and structure. Here are some intriguing insights about it:

  • Unique Structure: The complexity of its tetracyclic structure embodies a beautiful interplay of carbon atoms that contribute to its unique properties.
  • Biological Activity: Compounds similar to this one typically exhibit bioactivity, often interacting with biological systems in ways that can lead to medicinal applications. This raises interesting questions about its potential in pharmacology.
  • Chlorine Characteristics: The presence of chlorine in its structure is notable. Chlorinated compounds are often more lipophilic, which affects how they interact within biological systems.
  • Dimethylammonium Group: The inclusion of a dimethylammonium moiety suggests the compound may exhibit quaternary ammonium characteristics, making it ionically charged and possibly enhancing its solubility in biological contexts.

“The structure of a compound dictates its function, and this is particularly true for complex organic molecules like our subject of study.”

Applications and Importance

Understanding compounds like this opens the door to a myriad of potential applications:

  1. Medicinal Chemistry: Investigating its biological activity could lead to the development of new drugs.
  2. Material Science: The compound's unique properties may find utility in creating novel materials with specific functionalities.
  3. Environmental Chemistry: Studying its behavior in various environments could provide insights into chlorine compounds in nature.

As research continues, the full potential of this compound may yet be realized, contributing significantly to both the scientific community and practical applications across various industries.

Synonyms
Ethylamine, 2-(2-chloro-9,10-ethanoanthracen-9(10H)-yloxy)-N,N-dimethyl-, hydrochloride
9,10-Dihydro-2-chloro-9-(2-(dimethylamino)ethoxy)-9,10-ethanoanthracene hydrochloride
9,10-Ethanoanthracene, 9,10-dihydro-2-chloro-9-(2-(dimethylamino)ethoxy)-, hydrochloride
18801-35-9