Skip to main content

Flufenamic Acid

ADVERTISEMENT
Identification
Molecular formula
C14H10ClF3NO2
CAS number
530-78-9
IUPAC name
2-[4-chloro-2-[[3-(trifluoromethyl)benzoyl]amino]phenyl]acetic acid
State
State

At room temperature, Flufenamic acid is in a solid state, appearing as a crystalline powder.

Melting point (Celsius)
134.00
Melting point (Kelvin)
407.15
Boiling point (Celsius)
458.00
Boiling point (Kelvin)
731.15
General information
Molecular weight
281.67g/mol
Molar mass
281.6690g/mol
Density
1.4908g/cm3
Appearence

Flufenamic acid is typically a white to off-white crystalline powder.

Comment on solubility

Solubility of 2-[4-chloro-2-[[3-(trifluoromethyl)benzoyl]amino]phenyl]acetic acid

The solubility of 2-[4-chloro-2-[[3-(trifluoromethyl)benzoyl]amino]phenyl]acetic acid in various solvents can be quite intriguing due to its unique structure. The compound has polar functional groups which significantly influence its solubility characteristics. Here are some key insights:

  • Solvent Interaction: The presence of polar acetic acid and amine groups suggests that this compound is likely to exhibit higher solubility in polar solvents such as water and alcohols.
  • Hydrophobic Regions: The trifluoromethyl and chloro substituents contribute to hydrophobicity, which may reduce solubility in purely aqueous environments, indicating a potential preference for organic solvents.
  • pH Sensitivity: Being an acid, the solubility may vary depending on the pH of the solution, with deprotonation leading to increased solubility in alkaline conditions.

In summary, while 2-[4-chloro-2-[[3-(trifluoromethyl)benzoyl]amino]phenyl]acetic acid may dissolve well in polar solvents, its actual solubility can be highly influenced by factors such as solvent choice, temperature, and pH levels. This complexity makes it a fascinating subject for further studies regarding its solubility behavior.

Interesting facts

Interesting Facts About 2-[4-Chloro-2-[[3-(trifluoromethyl)benzoyl]amino]phenyl]acetic Acid

This compound, known for its complex structure, belongs to a class of pharmaceuticals called anti-inflammatory agents. It holds significant importance in the field of medicinal chemistry due to various properties and potential applications.

Key Properties and Applications

  • Pharmacological Significance: The presence of a chloro group and a trifluoromethyl group in its structure may contribute to its efficacy as an anti-inflammatory. Fluorinated compounds often exhibit increased metabolic stability, which is crucial for drug activity.
  • Analytical Interest: The unique structure allows for various analytical studies including NMR, mass spectrometry, and HPLC techniques, providing insight into the compound's behavior in biological systems.
  • Research Potential: Scientists are continually investigating the compound's mechanism of action and how it affects inflammatory pathways, which could lead to novel therapies for chronic inflammatory diseases.

Chemical Structure Highlights

The compound's design features several interesting aspects:

  • The amino group is essential for the biological activity, acting as a site for interaction with biological targets.
  • The trifluoromethyl group enhances lipophilicity, allowing greater permeability through biological membranes.
  • Chlorine introduces polarity, which can influence solubility and reactivity, making it a versatile compound in drug formulation.

Overall, 2-[4-chloro-2-[[3-(trifluoromethyl)benzoyl]amino]phenyl]acetic acid is a compound full of potential, and it exemplifies the intricate relationship between structure and function in medicinal chemistry.

Synonyms
BRN 2398921
ACETIC ACID, (4-CHLORO-2-(alpha,alpha,alpha-TRIFLUORO-m-TOLUAMIDO)PHENYL)-
4-Chloro-2-(m-trifluoromethylbenzamido)phenylacetic acid
17194-48-8
DTXSID50169191
(4-Chloro-2-(alpha,alpha,alpha-trifluoro-m-toluamido)phenyl)acetic acid
DTXCID1091682