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Bupivacaine

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Identification
Molecular formula
C18H28ClN3O2
CAS number
2180-92-9
IUPAC name
2-(4-chlorophenoxy)-N-[2-(diethylamino)ethyl]acetamide
State
State

At room temperature, Bupivacaine is a solid. It is typically handled and stored in its powdered form, although it is commonly used in solution for medicinal applications.

Melting point (Celsius)
108.00
Melting point (Kelvin)
381.15
Boiling point (Celsius)
409.30
Boiling point (Kelvin)
682.45
General information
Molecular weight
324.88g/mol
Molar mass
324.8810g/mol
Density
0.9780g/cm3
Appearence

Bupivacaine typically appears as a white crystalline powder. It is odorless and has a slightly bitter taste. The compound is often formulated into solutions for medical applications.

Comment on solubility

Solubility of 2-(4-chlorophenoxy)-N-[2-(diethylamino)ethyl]acetamide

The solubility of 2-(4-chlorophenoxy)-N-[2-(diethylamino)ethyl]acetamide can be influenced by several factors, including its chemical structure and the presence of polar and nonpolar groups. Understanding its solubility profile is important for applications in pharmaceuticals and chemical synthesis. Here are some key aspects to consider:

  • Polarity: The compound contains both polar (diethylamino and acetamide groups) and nonpolar (chlorophenyl group) regions, suggesting variable solubility in different solvents.
  • Solvent Interactions: It is likely to be soluble in polar solvents such as water and alcohols due to the presence of the amide and amine functional groups, which can engage in hydrogen bonding.
  • Organic Solvents: Conversely, it may also show solubility in less polar organic solvents, although the extent of solubility might be limited compared to more polar solvents.
  • Temperature: The solubility may increase with temperature, as is common for many organic compounds, facilitating molecular interactions between solute and solvent.

In summary, the solubility of 2-(4-chlorophenoxy)-N-[2-(diethylamino)ethyl]acetamide heavily relies on its specific chemical interactions within different solvent environments. This compound showcases an intriguing balance of properties that dictate its behavior in various media.

Interesting facts

Interesting Facts about 2-(4-chlorophenoxy)-N-[2-(diethylamino)ethyl]acetamide

2-(4-chlorophenoxy)-N-[2-(diethylamino)ethyl]acetamide, often referred to by its abbreviated name, is a fascinating chemical compound with a variety of applications and characteristics worth exploring. Here are some intriguing points regarding this compound:

  • Pharmaceutical Relevance: This compound is known for its potential use in the development of certain medications, particularly in the fields of analgesics and anesthetics, due to its ability to interact with specific receptors in the body.
  • Structure Significance: The presence of the 4-chlorophenoxy group contributes to the compound's lipophilicity, enhancing its ability to permeate lipid membranes. This is vital for its desired biological activity.
  • Diethylamino Moiety: The diethylamino group is notable for modulating the pharmacological properties of the compound, making it a valuable segment for enhancing its efficacy in biological systems.
  • Research Applications: Ongoing research is being conducted on this compound to better understand its mechanism of action, properties, and potential therapeutic benefits, particularly in chronic pain management.
  • Synergistic Effects: The unique combination of functional groups allows for the potential to create synergistic effects when paired with other known chemical agents, thereby increasing the effectiveness of treatments.

In summary, 2-(4-chlorophenoxy)-N-[2-(diethylamino)ethyl]acetamide is more than just a chemical formula; it embodies a wealth of possibilities in the realm of medicinal chemistry, showcasing the intricate synergy between its structural components and biological activities.

Synonyms
Clofexamide
1223-36-5
Amichlophene
Clofexamida
ANP 246
Clofexamidum
DTXSID6046424
ANP-246
071P4J77HF
2-(p-Chlorophenoxy)-N-(2-(diethylamino)ethyl)acetamide
N-(2-Diethylaminoethyl)-4-chlorophenoxyacetamide
2-(4-chlorophenoxy)-N-(2-(diethylamino)ethyl)acetamide
DTXCID4026424
2-(4-Chlorophenoxy)-N-[2-(diethylamino)ethyl]acetamide
2-(p-Chlorophenoxy)-N-[2-(diethylamino)ethyl]acetamide
214-951-6
ANP 246; Amichlophene; Chlofexamide
NCGC00164540-01
Chlofexamide
Acetamide, 2-(4-chlorophenoxy)-N-(2-(diethylamino)ethyl)-
Acetamide, 2-(4-chlorophenoxy)-N-[2-(diethylamino)ethyl]-
Clofexamide [INN:DCF]
IEM 455
Clofexamidum [INN-Latin]
Clofexamida [INN-Spanish]
NP 246
CAS-1223-36-5
EINECS 214-951-6
BRN 1986755
Clofexamid
UNII-071P4J77HF
CLOFEXAMIDE [INN]
CLOFEXAMIDE [MART.]
CLOFEXAMIDE [WHO-DD]
orb1700836
SCHEMBL1604514
CHEMBL2106515
Acetamide, 2-(p-chlorophenoxy)-N-(2-(diethylamino)ethyl)-
Tox21_112169
AKOS002310795
Tox21_112169_1
NCGC00164540-02
CS-0026468
NS00023987
ST45184521
Q5134877
N-[2-(diethylamino)ethyl]-2-(4-chlorophenoxy)acetamide
2-(4-Chlorophenoxy)-N-[2-(diethylamino)ethyl]acetamide #